Microsoft word - tuth.doc
DRUG & THERAPEUTICS LETTER
A Quarterly Bulletin from
Drug Information Unit (DIU)
Department of Clinical Pharmacology
Tribhuvan University Teaching Hospital
Institute of Medicine, Maharajgunj, Kathmandu
January - March 2007
What can be done about
Drug induced pancreatitis.
Drugs and gingival
of virus. The earliest serological marker
Drug Information Unit
What can be done about hepatitis B?
serum transaminase levels can rangefrom around 3-fold to over 100-fold.
hepatitis B virus and are therefore at riskof developing chronic liver disease.
In about 95% of adults, acute infectionresolves
transmission globally is infection during
those infected during early childhood.
antibody to this antigen (anti-HBs) in the
Failure to clear the hepatitis B virus can
lead to chronic infection. This is definedas infection that continues for more than6 months with persistence of HBsAg,
dose of virus, the shorter this duration.
hepatitis B core antigen (anti-HBc).
During this period, patients may feelunwell,
Up to 20% of patients with chronichepatitis progress to cirrhosis, of whom
Consensus Conference on Hepatitis B.
Liver Dis 2004;8:255-66.
5. Ganem D, Prince AM. Hepatitis B
virus infection-natural history and clinical
blood. It is therefore important to avoid
patients with cirhosis type B. Hepatology
body fluids. Injecting drug users shouldalso avoid sharing needles, syringes or
Drug induced pancreatitis
Hepatitis B vaccine is highly effective at
(ideally within 48 hours) after exposure,
inhibitors, NSAIDs, aminosalicylates (mesalazine, sulfasalazine), angiotensin
II receptor antagonists. Individual drugs
treating chronic hepatitis B infection is to
individuals. In all individuals, the ideal
agents. There is insufficient informationavailable on the course of the disease
Drug and Therapeutics Bulletin, vol
WHO, 2002.Hepatitis B
2002(online).Department ofCommunicable Diseases Surveillanceand Response. Available:
http://www.who.int/csr/disease/hapatitis/Hapatitis B _whocdscsrlyo2002_2.pdf
Drugs and gingival bleeding
cause an erythematous reaction whichcan result in gingival bleeding.
Bleeding gums are usually the result ofplaque-induced
result from direct trauma, viral, fungal or
rapid destruction of periodontal tissues,
erythematosus. Although it is a relatively
have adverse effects that may directly or
gingiva or opportunistic infections.
Drug Information Unit (DIU), TUTH
Patients taking anticoagulants such aswarfarin or heparin may develop gingival
Question answering services.
dependent on the level of oral hygieneand the length or time the patient has
Study on Adverse Drug Reactions:
phenytoin, cyclosporin and nifedipine.
drug, type of reactions, outcome andany sequelae from the reaction. The
The use of antibiotics (both systemically
steroids and other drugs which allow theovergrowth
Prof. Kumud Kumar KafleEditor
: Dr. Sanu Maiya Shakya.
Department of Clinical Pharmacology, Drug Information Unit, Room Number: 1-
85 Doctors' Room Block, TU Teaching Hospital, P.O. Box: 3578, Maharajgunj,
Phone No. : 4412404 Extn 1093, E-mail: firstname.lastname@example.org
De Nardi P, et al. Glyzerintrinitrat vs. Botulinustoxin A bei chronischen Analfissuren Langzeitresultate beim Vergleich von Glyzerintrinitrat und Botulinustoxin A bei der Behandlung chronischer Anal fissuren De Nardi P, Ortolano E, Radaelli G, et al. Comparison of glycerine trinitrate and botulinum toxin-A for the treatment of chronic anal fissure: long-term results. Fragestellu
3B SCIENTIFIC® PHYSICS Basic solar energy set 1000839 Instruction sheet 03/12 ALF 1 Holder for metering panel 2 Solar metering panel 3 Insulating 1. Safety instructions 3. Contents / Technical data The metering panels and halogen lights get hot dur-ing the experiments so that there is a risk of burns. • Let the sample panels and halogen lights cool The thermometers