Med Health Care and Philos (2009) 12:169–178DOI 10.1007/s11019-009-9190-2
S C I E N T I F I C C O N T R I B U T I O N
The ethics of self-change: becoming oneself by wayof antidepressants or psychotherapy?
Ó Springer Science+Business Media B.V. 2009
This paper explores the differences between
character of the person in question, and this is important
bringing about self-change by way of antidepressants versus
from an ethical point of view. In the article, the concepts of
psychotherapy from an ethical point of view, taking its
self-change, authenticity, temperament and character are
starting point in the concept of authenticity. Given that the
presented and used in order to understand and flesh out the
new antidepressants (SSRIs) are able not only to cure psy-
relevant ethical differences between the practice of psy-
chiatric disorders but also to bring about changes in the
chotherapy and the use of antidepressants. Looping,
basic temperament structure of the person—changes in self-
collective effects of psychopharmacological self-change in
feeling—does it matter if one brings about such changes of
a cultural context are also considered in this context.
the self by way of antidepressants or by way of psycho-therapy? Are antidepressants a less good alternative than
psychotherapy because antidepressants are in some way less
Enhancement ethics Á SSRIs Á Phenomenology Á
authentic than psychotherapy? And, if so, what does this
mean exactly? In this paper I try to show that the self-change brought about by way of antidepressants challengesbasic assumptions of authentic self-change that are deeply
ingrained in our Western culture: that changes in self shouldbe brought about by laborious ‘self-work’ in which one
In this article, I will explore the differences between
explores the deep layers of the self (the unconscious) and
bringing about self-change by way of antidepressants ver-
comes to realise who one really is and should become. To
sus psychotherapy from an ethical point of view. Given that
become oneself has been held to presuppose such a journey.
the new antidepressants (SSRIs) bring about changes in the
While the assumed importance of self-work appears to be
basic temperament (self-feeling) structure of the person—a
badly founded on closer inspection, the notions of exploring
hypothesis that I will try to make credible—does it matter
and knowing oneself appear to be more promising in
if one brings about such changes of the self by way of
fleshing out an ethical distinction between psychopharma-
antidepressants or by way of psychotherapy? Are antide-
cological and psychotherapeutic practice with the help of
pressants a less good alternative than psychotherapy
the concept of authenticity. Psychotherapy, to a much
because treatment with antidepressants is in some way less
greater extent than psychopharmacological interventions,
authentic than psychotherapy? And, if so, what does this
involves the whole profile of the self in its attempts to effect
mean exactly? These are questions which I will strive to
a change, not only in the temperament but also in the
answer in what follows. The article is thus a contribution tothe bioethical debate on new medical technologies (thera-pies), which is the very topic of this whole thematic section
of Medicine, Health Care and Philosophy. In the article, I
Department of Philosophy, Centre for Studies in Practical
will also address the cultural components of the success of
Knowledge, So¨derto¨rn University College, 141 89 Huddinge,
the new antidepressants. My point of departure is a phe-
nomenological analysis of the effects of the SSRIs, which
involves exactly the relevant life-world issues of the
people in general) to look upon certain conditions as
pathologies with a biological basis, rather than as the
Presently we are facing an explosion of diagnoses of
painful experiences of a normal life. Indeed, it appears
depression and anxiety in the Western world. It is hard to
highly probable that the development and aggressive
find reliable data on prevalence, but according to studies
marketing of these new drugs by pharmaceutical compa-
carried out by the World Health Organization, depression
nies have resulted in a more liberal interpretation of the
will soon become the second most common cause of dis-
diagnostic criteria for depression and anxiety disorders (in
ability, trailing only ischemic heart disease (Kramer
both psychiatric manuals and medical practice) (Healy
p. 151ff.). Anxiety disorders—whether they occur together
). This liberalisation of criteria is not necessarily a bad
with depression or on their own—are also on the rise and
thing only, since, clearly, many people have been helped to
are receiving increased attention. A clear sign of this is the
a far better life by the new drugs. To visit the doctor
ever more sophisticated taxonomies of anxiety-related
seeking help for psychic complaints associated with
psychiatric conditions found in the diagnostic manuals of
depression or anxiety appears to have become more
mental disorders published by medical associations (par-
socially acceptable during the last 20 years or so. These
ticularly the fourth edition of the Diagnostic and Statistical
conditions have undergone, in other words, a process of
Manual of Mental Disorders, or DSM-IV )). It can be
‘de-stigmatisation’. At the same time the disorders have
estimated that more than 5% of the inhabitants of Western
also changed in character as they have expanded their
countries suffer from depression or an anxiety disorder at
scope. The kernels of depression and anxiety disorders are
the present time, and that at least 25% will fall ill at one
essentially the same as before the advent of the new drugs,
time or another in their lives.1 These numbers are
but the territory of illness has clearly been expanded to
remarkable, considering the fact that depression and anxi-
include self-feeling-problems, which were earlier consid-
ety disorders appear to have been rare conditions only
ered painful, but still not medical in nature.4
30 years ago, and the rapidly increasing prevalence cer-tainly calls for investigation.2 Why have we become so
depressed and anxious? What are we to do about it?
antidepressants, which inhibit the reuptake of both serotonin and
The most important factor underlying the increased
noradrenalin in the synapse, includes venlafaxine (Efexor, Effexor)and mirtazapine (Remeron). Although originally marketed to treat
prevalence of these psychiatric disorders is probably the
depression, the ‘new antidepressants’ have also been shown to have
emergence of a new group of antidepressants, the selective
beneficial effects on anxiety. In this article, I will use the terms (new)
serotonin-reuptake inhibitors (or SSRIs)—the best known
antidepressants and SSRIs interchangeably. In most countries, pre-
of which is fluoxetine or Prozac—which are frequently
scriptions for SSRIs account for more than 75% of all prescriptionsfor antidepressants; moreover, the effects of self-change on which I
used to treat patients diagnosed with depression or anxi-
am focusing have been associated mainly with SSRIs. For an over-
ety.3 The availability of these drugs has led doctors (and
view of the development of antidepressant pharmaceuticals since thetime of the Second World War, see David Healy’s book The Anti-depressant Era ).
1 This is in fact a rather modest estimation. Some investigations show
4 In the DSM-IV, the distinguishing characteristic of depressive
a considerably higher prevalence of these disorders, see Horwitz
disorders is the presence of what is called ‘‘a major depressive
episode’’ (DSM-IV p. 356). This condition is adjudged to be
2 See Healy (). That the disorders in question were rarely
present if a depressed mood (sadness, emptiness) and a loss of interest
diagnosed 30 years ago does not necessarily mean, of course, that
or pleasure have been present most of the day, nearly every day, for at
they were in fact rare in the population.
least two weeks, and if, in addition, at least three of the following
3 Antidepressants can be divided into several different subgroups.
seven criteria have also been fulfilled during this period: significant
Two subgroups of antidepressant drugs prescribed more frequently
weight change; insomnia or hypersomnia; psychomotor agitation or
before the introduction of SSRIs about 20 years ago are the
retardation; fatigue or loss of energy; feelings of worthlessness or
monoamine oxidase inhibitors (or MAOIs), and the tricyclics (so
excessive or inappropriate guilt; diminished ability to think or
named for their three-ring molecular structure). These drugs are often
concentrate; and recurrent thoughts of death. These symptoms must
effective against depression but have more bothersome side effects
also have resulted in ‘‘clinically significant distress or impairment in
than the SSRIs. They are also toxic in high doses, and this fact, in
social, occupational, or other important areas of functioning,’’ and
combination with the risk of side effects, explains doctors’ reluctance
they should not have been directly caused by medication or
to prescribe them to patients who are not severely depressed. For the
bereavement (the loss of a loved one).
treatment of anxiety disorders, doctors have historically had access to
If we turn to how anxiety disorders are described in the DSM-IV, we
other kinds of drugs than antidepressants, such as the benzodiaze-
find a similar litany of deviant feelings—of problems involving
pines; these drugs, however, have become increasingly unpopular,
altered embodiment and estranged engagement with the world. Here,
since they are quite addictive. At the end of the 1980s, the SSRIs were
the common characteristic of the disorders that are treated with SSRIs
introduced; they were made famous by the commercial success and
is the panic attack—an excess of anxiety triggered by an alarming
cultural impact of Prozac (generically, fluoxetine). In some parts of
situation. A panic attack is specified as: ‘‘a discrete period of intense
Europe another SSRI, citalopram (Celexa), has been more popular
fear or discomfort,’’ in which symptoms like pounding heart,
than fluoxetine. Other widely prescribed SSRIs are paroxetine
sweating, trembling, shortness of breath, chest pain, nausea, fear of
(Seroxat, Paxil) and sertraline (Zoloft). A class of similar
losing control, going crazy, or dying are developed abruptly and reach
The ethics of self-change: becoming oneself by way of antidepressants or psychotherapy?
The question of what kind of creatures depression and
and which are now instead increasingly being treated by
anxiety disorders really are is a very complicated one. That
way of antidepressants. In this article, I will try to show
they are real things, and not somehow invented or created
that the success of the new antidepressants challenges basic
by diagnostic manuals, pharmaceutical companies, or
assumptions about authentic self-change that are deeply
doctors seems to be beyond dispute. But, nevertheless, the
ingrained in our Western culture: changes in self should be
differentiation and boundaries of the disorders in question
brought about by laborious ‘self-work’ in which one
appear to be very flexible and elastic and this is probably
explores the deep layers of the self (the unconscious) and
related to cultural components and the holistic character of
comes to realise who one really is and should become. To
the phenomena in question. Persons, and not only their
become oneself has been held to presuppose such a jour-
brains, become depressed and anxious, and our ways of
ney, but this is now increasingly contested. What
judging if they are ill or not are interpretative in nature—
components of the old ethics of authenticity are worth
tied to understanding of symptoms, which are culturally
holding on to and which ones should better be abandoned
loaded in various ways.5 I will return to this cultural
when we embrace the new possibilities of pharmacological
‘embededdness’ of depression and anxiety disorders
self-change? This is the basic question which this article
The expansion of the diagnoses of depression and anx-
iety disorders with the help of the new drugs hasconsequently changed the treatment pattern for certain
kinds of human problems. Psychotherapy, which has beenthe standard solution for a long time for the kind of self-
A lingering suspicion, ever since the first reports of the
feeling-problems of the recently expanded categories of
success of Prozac, has been that the new antidepressants, in
depression and anxiety disorders, now increasingly has to
addition to relieving the symptoms of psychiatric disorders,
compete with antidepressants. That psychotherapy, espe-
also have other effects that help explain their popularity.
cially in the form of a long time project, is a much more
Do not the new antidepressants also affect our self-per-
expensive alternative that antidepressants is certainly a
ception (our sense of who we are), in the way Peter Kramer
decisive factor in the former losing ground. However, the
illustrates by way of clinical examples in his well-known
development in question also seems to be related to
book, Listening to Prozac (According to Kramer,
changes in norms regarding preferred ways of under-
some of his patients went through the experience of
standing and dealing with the type of ‘neurotic’ problems
‘becoming themselves’ while on Prozac, whereas others
that have been addressed for centuries by psychotherapy
had the experience of ‘losing themselves,’ despite feelingbetter on the drug. Similar characterisations of the effectsof SSRIs can be found in other studies (Knudsen et al.
), but it is difficult to know how we should interpret
a peak within 10 minutes (DSM-IV p. 432). The panic attacksare typically recurrent, and they are often associated with being in a
them, since we lack a comprehensive understanding of
special type of situation (meeting or speaking to strangers in social
what the term ‘self’ means in this context. What might
phobia, for instance). The sufferer not only experiences anxiety while
‘enhancing the self’ or ‘becoming oneself’ or ‘losing
having the attacks, he is also in many cases constantly anxious about
oneself’ possibly mean in the case of antidepressants? Has
the significant change taken place in the dimension of
Presumably, not all physicians strictly abide by these criteria when
feelings (self-feeling) or in the dimension of thoughts (self-
making their diagnoses; nonetheless, they give a clear indication ofthe types of matters physicians are expected to investigate in their
understanding)? The self (or personality) is apparently a
encounters with patients: painful, estranging feelings which make it
concept that refers to a basic disposition to feel, act, and
hard to find oneself at home with oneself and in the world. Diagnosis,
think in certain ways (Goldie ). How could antide-
in these cases, represents a pronouncement concerning the phenom-
pressants come to have an effect on this basic disposition in
enological life-world; yet, the criteria were not derived in anytheoretically reflective manner. Indeed, the very rationale for the
relieving the symptoms of depression and anxiety?
compilation of the DSM was to delineate psychiatric diagnoses
In a recently published article—‘Do antidepressants
without any reference to (psychoanalytic or biological) theory; it
affect the self?’ (Svenaeus )—I tried to show, with the
should thus come as no surprise that the manual does not feature an
aid of phenomenologists such as Martin Heidegger )
exposition of basic concepts or theoretical discussions of the nature ofmental illness.
and Thomas Fuchs (that the effects of the new
5 A very sharp illustration of this is the case of ‘‘social anxiety
antidepressants must be thought of in terms of changes in
disorder,’’ a recent disorder of DSM, which is essentially a new name
self-feeling, or, more precisely, self-vibration of embodi-
for the older notion of social phobia better handled to expand the
ment. This phenomenological concept comes close to the
disorder in question into the territories of painful shyness. See
ancient notion of temperament—a basic disposition of the
Christopher Lane: Shyness: How Normal Behaviour Became aSickness
self to develop characteristic moods—the most famous of
the four classic temperaments being the melancholic per-
sonality type (Radden ). In the article I present theidea of a spectrum of bodily resonances, which extends
Kramer’s words from his patients on Prozac—‘‘I am losing
from the normal resonance of the lived body, in which the
myself’’ or ‘‘I am becoming myself’’—remind us of
body is able to pick up a wide range of different moods; to
another practice and technique of the psychiatrist than
various kinds of sensitivities, preferences and idiosyncra-
psychopharmacology—namely psychotherapy. In cases in
sies, in which certain moods are favoured over others; to
which the new antidepressants have good effects, the
cases that we unreservedly label pathologies because the
results seem to be similar in many ways to the good effects
body is severely out of tune, or even devoid of tune, and
of the old ‘talking cures’ of psychotherapy. Prozac appears
thus useless as a tool of resonance. Different cultures and
to make people less ‘neurotic,’ to use a Freudian language
societies favour slightly differently attuned self-styles as
which has become slightly out of fashion. If I am right in
paradigmatic of the normal and of the good life, and the
claiming that the new antidepressants are not only targeting
popularity of the SSRIs can therefore be explained not only
distinct disorders but also effect changes in self-feeling,
by defects of embodiment (biology) but also by the pres-
this is not strange, but rather logical. The general increase
ence of certain cultural norms in our contemporary society
of serotonin (and other neurotransmitters) in the synapses
of the brain makes people feel less miserable and enhance
It is common in the contemporary philosophy of feelings
their sense of self-worth.7 This is not the same thing as
to distinguish between emotions and moods. Emotions
making them feel happy or euphoric—Prozac is not a
have an object and are based upon beliefs (love, hate).
‘happy pill’—but it means that the spectrum of moods in
Moods rather color the way in which things appear to the
which the person lives becomes altered in a characteristic
subject in general (joy, sadness). Moods open up a world to
way by the antidepressant. The mood spectrum becomes
human beings in which things matter to them in different
richer as the person is no longer stuck in sad moods and
ways. Although moods certainly do not contain thoughts in
thus more easily able to enjoy other attunements than the
the same explicit way that emotions do, they nevertheless
dark ones. The world opens up in more multifaceted ways
determine what kinds of thoughts the thinker will be able to
and allows the self to become at home with itself and in the
entertain. Moods are not something I append to my
world. However, the mood spectrum also becomes poorer
thoughts, to make them happy or sad, depending on how I
in that the steep ups and downs of intense moods such as
am attuned; on the contrary, the moods I happen to be
sadness and joy are cut off. The sine curve of life is
immersed in underlie and inform the very process of
characteristically flattened out by antidepressants, some-
thought formation. Feelings of joy or sadness will give rise
thing that can be both praised and lamented by patients
to very different kinds of thoughts, with a very different
content. This, of course, is the reason why thoughts of
Antidepressants have become an alternative to psycho-
death, guilt and hopelessness typically occur in the mental
therapy for many persons. In some cases this is so mainly
for financial reasons; a half-year prescription for SSRIs
Feelings, especially in the form of moods, are basic to
costs less than 1 h of psychotherapy in most Western
our being-in-the-world, in Heidegger’s phenomenology,
countries today. This means that the majority of the people
since they open up the world as meaningful, as having
who are taking antidepressants could never have afforded
significance. They are the basic strata of what Heidegger
treatment by a psychotherapist, regardless of whether or
refers to as facticity, our being thrown into the world prior
not they have wanted it. Depending on the health care
to having made any thoughts or choices about it. We find
insurance systems of different countries, it is sometimes
ourselves there, in the world, always already busy with
possible to get psychotherapy paid for by one’s employer,
different things that matter to us, together with other peo-
or by the state, but the rules and regulations for this seem to
ple. And this ‘mattering to’ rests on an attunement, a mood-
become stricter and narrower every day. At least if we are
quality which the being-in-the-world always already has.
talking about psychodynamic therapy or psychoanalysis,
We do indeed not choose our moods; they come to us and
which demand rather lengthy treatment periods. Cognitive-
cannot easily be changed. Or, at least, this was the case
based talking cures of five to ten hours over a couple of
before the advent of the new antidepressants.6
months’ time are more affordable, although in many casesstill difficult for patients to get access to. Cognitive(behavioural) therapy has generally strengthened its
6 I do not want to deny, of course, that people have used drugs forthousands of years to deal with painful moods (alcohol). But the
7 That the new antidepressants have effects, not only on distinct
changing-temperament effect of the SSRI’s appear to be of another
disorders, but also on personality and social behaviour, has been
type altogether than the drunkenness effect of alcohol and narcotics.
shown in controlled studies, e.g.: Knutson et al.
The ethics of self-change: becoming oneself by way of antidepressants or psychotherapy?
position in relation to psychodynamic therapy over the last
think this way, but contemporary psychopharmacology
15 years, and this seems to be linked to cognitive therapy’s
shows us that psychiatrists and other doctors in the future
having effects similar to those of the drugs. Cognitive
will be able to treat a lot of conditions which are painful
therapists have also taken on the challenge to evaluate their
and unwanted but do not merit the label of disease. I will
treatment in the same way drugs are tested—randomised
not go into detail in this article, since this would take us
control trials—and the researchers have been fairly suc-
into a full theory of health and disease, but my point is that
cessful in proving the therapy to have an effectiveness
the new antidepressants have taught us that drugs can do
equal to that of the drugs in cases of mild depressions and
other things for us than treating illness, even if contem-
porary medicine and psychiatry do not admit that they do
My aim in this article is to compare treatment with anti-
depressants with psychotherapeutic treatment, and to
The message that antidepressants treat disorders while
explore the ethical matters which this comparison might
psychotherapy treats the self, and that they thus cannot be
raise.8 In the introduction to the topic I have just made, I
compared since they do totally different things, is conse-
have tried to make a case for a view that many people and
quently false. This seems to put much of the use of the new
parties might contest: namely that antidepressants and psy-
antidepressants under the umbrella of medical enhance-
chotherapy have similar effects—do the same thing. It will
ment, rather than treatment of disease (disorder). Medical
become clear in the rest of this article that I certainly do
enhancement by way of new technologies (therapies) has
admit to there being important differences between treat-
attracted a lot of interest in bioethics recently, and the lit-
ment with antidepressants and psychotherapy, and that the
erature is already vast.11 Most of the literature, however,
comparison might come out differently depending on which
deals with genetic enhancement rather than with psycho-
of the many brands of psychotherapy we throw into the
pharmacology (for an exception, see Elliott and Chambers
contest. However, summing up my preview of the prob-
). As we saw above, the enhancement in the case of
lematic so far, I will now state explicitly two related but
antidepressants takes on a peculiar form which might be
separate claims, which I have tried to make credible, and
relevant also to the analysis of other forms of medical
which will now serve as points of departure in my compar-
enhancements: the change in question is rather to be
ison of treatment with antidepressants and psychotherapy.
thought about as a becoming or finding oneself, than as an
First claim: The sharp distinction between curing a
psychiatric disorder and changing the self does not hold up;
When one asks patients who have taken or are taking
psychotherapy has had effects in both domains as long as it
antidepressants about their preferences when it comes to
has existed, and the new antidepressants cross over this line
pharmacological treatment and psychotherapeutic treat-
as well. Second claim: The expansion of the domains of
ment, they often answer that the latter is to be preferred if it
psychiatric illness in cases of depression and anxiety dis-
works.12 The problem might be that it does not work (did
orders has been supported by the advent of the new
not work for this particular patient) or that it has not been
antidepressants. An important point in naming something a
possible to get psychotherapeutic treatment. Many patients
psychiatric disorder is, among other things (such as
allowing sick leave or admission to other social benefits),
For a good discussion of the current uses of the concept of mental
that it can be treated. Treatment by way of pharmaceuticals
disorder, see Ross In my view, the position stated by JeromeWakefield (is a promising one. Wakefield distinguishes
demands diagnosis; that is, if we have a pill that helps a
two related criteria of mental disorders—they are ‘‘harmful dysfunc-
condition, we will soon have a diagnosis too, since the
tions’’—which means that the individual must have a biological or
system demands this. Psychotherapeutic treatment has not
psychological malfunction, which is responsible for the suffering
and does not demand diagnosis, whereas treatment with
(s)he is presently experiencing. The suffering must not only be due toexceptional, stressful circumstances, or, indeed, personality problems.
The problem of fleshing out the exact distinction between patholog-
To add my two claims together: Pharmaceutical treat-
ical malfunctioning and temperament-problems is not solved
ment does not equal the curing of diseases (disorders), even
automatically by way of Wakefield’s theory. However, the analysis
if the DSM and doctors (and perhaps most lay people too)
of the concept of dysfunction by way of natural evolution, which hesuggests, would have us look for temperament-profiles which are
prefer to think in this way. Indeed, we have been taught to
dysfunctional in most (or every) kind of human society when drawingthe border line between mental disorder and other self-feeling-
8 The article is inspired by a qualitative interview study in which 30
problems. Regarding this question see also footnote 4 above.
patients and doctors were asked about their experiences with and
views on antidepressants (Svenaeus but this material will not
12 At least this seems to be the case in Sweden (Svenaeus
be presented in this article, which takes on a more philosophical
other countries might display other patterns either because psycho-
therapy was never established as the main practice of self-change
9 For further evidence in favour of these two claims, see Healy
(Asia, Africa), or because it has already been totally outdated as such
a practice by the new antidepressants (the United States).
answer that an ideal would be a combination of the two
this really true? Does not ‘becoming oneself’ on Prozac
forms of treatment. Why do patients prefer the talking cure
also involve a kind of self-knowledge? Let us come back to
even if it is more time consuming and painful than phar-
the patient Tess, who Peter Kramer describes in his book,
macological treatment (which has its problematic side
effects too, of course, see Healy )? I think the answer
Tess is about 35 years old and she has suffered a chaotic
can be found in the fact that psychotherapy conforms to a
and painful childhood. She grew up in a poor neighbour-
generally prescribed pattern of self-change in our culture
hood, the eldest of nine siblings, her father an alcoholic who
and society, whereas antidepressants do not. The self
abuses her and her mother. When her father dies the mother
should be changed by ‘work’ carried out by the person
enters a depression, something that makes Tess responsible
herself in which she uncovers her true, unconscious self
in practice for her younger sisters and brothers. In some
beneath the surface and in which she changes according to
strange way Tess faces the demands, she takes care of the
the insights brought about by this cumbersome process.
house, her siblings and her mother, and she also manages to
Pharmacological self-change is ‘fake’, it does not really
finish school with good grades. At the age of 17 she marries
make one oneself, so to speak, rather it is a cosmetic
an older man and moves into his house with all her siblings,
change of the surface which is not true to the deep layers of
acting as their mother. In spite of her husband’s being an
alcoholic, she manages to make a business career as a per-
Authentic self-change by way of scrutinizing and getting
sonnel administrator out of her skills in motivating, inspiring
to know oneself has deeper historical roots than Freudian
and nurturing others. She also takes care of her depressed
psychotherapy. The examined life as the only life worth
mother and engages in different social projects in her own
living is Socrates’ famous credo, and the Augustinian idea
neighbourhood. When her brothers and sisters have left the
of finding God in your own heart, or the romantic image of
house the marriage ends, and Tess moves on into new
the genius expressing his true nature in poetry and art, are
relationships with other men, repeating the characteristic
later versions of this general Western ethics of authenticity
pattern with abusive alcoholics. After a hasty break-up from
(Taylor But during the twentieth century the talking
one of these short, miserable relationships Tess falls into a
cure of psychotherapy became the dominant practice of this
depression, which finally brings her to Kramer’s office:
self-search. True, far from everyone actually entered psy-
She was a pleasure to be with, even depressed. I ran
chotherapy (this has always to a large extent been the
down the list of signs and symptoms, and she had them
privilege of the educated middle class), but psychotherapy
all: tears and sadness, absence and hope, inability to
and its basic meta-psychological assumptions nevertheless
experience pleasure, feelings of worthlessness, loss of
became deeply ingrained in the Western ethics of self-
sleep and appetite, guilty ruminations, poor memory
change.14 Even though psychotherapy is now increasingly
and concentration. Were it not for her many obliga-
driven out of business by other forms of treatment and
tions, she would have preferred to end her life. And yet
practices (not only antidepressants, but also different
I felt comfortable in her presence. Though she looked
Eastern meditative practices of mindfulness), the peculiar
infinitely weary, something about Tess reassured me.
pattern of authentic self-change which it has established is
She maintained a hard-to-place hint of vitality—a
still a part of our culture. In the following I will investigate
glimmer of energy in the eyes, a sense of humor that
which parts of this ethics we should hang on to and which
was measured and not self-deprecating, a gracious mix
parts of it could better be abandoned.
of expectation of care and concern for the comfort ofthe listener. It is said that depressed mothers’ children,since they have to spend their formative years gauging
mood states, develop a special sensitivity to small cuesfor emotion. In adult life, some maintain a compulsive
The key difference between psychotherapy and psycho-
need to please and are thought to have a knack for
pharmacological treatment, as we have seen, seems to be
behaving just as friends (or therapists) prefer, at
that the former, in contrast to the latter, involves self-
whatever cost to themselves. Perhaps it was this
knowledge and self-work as central parts of the self-change
hypertrophied awareness of others that I saw in Tess.
process. This is what makes psychotherapy authentic and
But I did not think so, not entirely. I thought what I was
drugs inauthentic, the former better than the latter. But is
seeing was a remarkable and engaging survivor, suf-fering from a particular scourge, depression. […] Had I
13 Regarding the patterns and history of images of contemporary
been working with Tess in psychotherapy, we might
authentic life, see Guignon (See also Kramer
have begun to explore hypotheses regarding the source
14 For a good account of the development of psychiatry and
of her social failure: masochism grounded in low self-
psychotherapy in the 20th century, see Shorter (
The ethics of self-change: becoming oneself by way of antidepressants or psychotherapy?
worth, the compulsion of those abused early in life to
‘‘better than well,’’ in contrast to the old ‘‘better but not
seek out further abuse. Instead, I was relegated to the
well’’ of Tofranil. She is much more outgoing and self-
surface, to what psychiatrists call the phenomena. I
confident, and she is no longer plagued by sadness and guilt
stored away for further consideration the contrast
when thinking about the past. She is not afraid of conflicts
between Tess’ charm and her social unhappiness. For
and separations, and her social life changes as she says
the moment, my function was to treat my patient’s
goodbye to some of her old friends and welcomes new ones.
depression with medication. (Kramer pp. 3–4)
She is no longer absorbed by the caretaking of her mother,but she does not totally abandon the mother, and she now has
Kramer tries first with Tofranil (a so-called tricyclic,
the confidence to confront her about the family history. As a
older form of antidepressant) and gets a rather good
matter of fact, the effect Prozac has on Tess resembles what
response. Tess feels better, she sleeps and eats better, and
one could hope for in a successful psychotherapy. There is
she feels less stressed out and apathic. She is ‘‘herself
just one main difference—the pill, rather than the talking,
again,’’ as she puts it. But Kramer is not entirely satisfied;
remembering and understanding, does the job.
he still perceives signs of an underlying depression, which
Let us return to the question that brought us to the story of
is disquieting in the face of Tess’s family history (the
Tess. Given the fact that pharmaceutical treatment does not
chronically depressed mother). The patient is still vulner-
involve the same kind of ‘work’ on the self that psycho-
able and worries a lot about conflicts at work, and she is
therapeutic treatment does, is it also devoid of increased
sad about her shipwrecked relationship with Jim—her lat-
self-knowledge? I do not think it is entirely correct to say
est abuser. Tess’s psychotherapy with the referring
that the drug does not affect Tess’s self-knowledge. It does,
psychologist does not seem to have any significant effect,
but not in a form that precedes the self-change in question;
but it is hard to tell why, since Kramer is remarkably silent
rather, the change itself makes Tess look back on her old
on this point in the book. Why, indeed, does he not try
self, comparing it to the new one. In this position, with the
psychotherapy, with himself as the consulting therapist?
help of the drug, Tess develops a more thorough under-
We do not get any answers here from Kramer. In any case,
standing of what she lacked before, and what she did wrong.
But she does not do so by facing moods of despair, grief and
Then Prozac was released by the FDA. I prescribed it
anxiety, going back to the unconscious marks that the past
for Tess, for entirely conventional reasons—to termi-
has left; Tess’s self-vibrations—to hint at my earlier phe-
nate her depression more thoroughly, to return her to
nomenological characteristic of the basic temperament of
her ‘‘premorbid self’’. My goal was not to transform
the self—changes directly by way of the chemical, not by
Tess but to restore her. But medications do not always
behave as we expect them to. Two weeks after starting
It is true that the effect Prozac has on Tess is unusually
on Prozac, Tess appeared at the office to say she was no
quick and solid, and in this regard hardly typical. In my
longer feeling weary. In retrospect, she said, she had
own interviews with patients who have gone through SSRI
been depleted of energy for as long as she could
treatments I rarely find the remarkable from-darkness-to-
remember, had almost not known what it was to feel
light-in-a-few-days scenario of Tess (Svenaeus ). But
rested and hopeful. She had been depressed, it now
the basic structure of the change in question—the effects in
seemed to her, her whole life. She was astonished at the
feelings of self-worth, confidence and stability linked to a
sensation of being free of depression. She looked dif-
changed mood structure—is found in my study also, and in
ferent, at once more relaxed and energetic—more
other ones (Knudsen et al. ). In this regard Tess is
available—than I had seen her, as if the person hinted at
typical, although one should not forget that far from
in her eyes had taken over. She laughed more fre-
everyone living in a depressed or over-anxious mood is
quently, and the quality of her laughter was different,
helped by antidepressants in this swift way.
no longer measured but lively, even teasing. With this
Why would such a change of temperament—if the
new demeanor came a new social life, one that did not
person welcomes it—be less authentic—less real, less
unfold slowly, as a result of a struggle to integrate
true—than a similar change brought about by psychother-
disparate parts of the self [read, by way of psycho-
apy? That the change in question is chemical in nature,
therapy], but seemed, rather, to appear instantly and
rather than psychological, is not a good answer. The
full-blown. ‘‘Three dates a weekend,’’ Tess told me. ‘‘I
chemistry of the brain of a patient who goes through psy-
must be wearing a sign on my forehead!’’ (Kramer
chotherapy also changes, and the raised serotonin levels of
Tess’s brain, as well as of the psychotherapy-cured brain,are brain states, which represent feelings and thoughts for
Is Tess becoming manic? No, hardly; with Prozac she has
the persons who are in them. If we want to hold to a basic
rather gone through a personality change that makes her feel
difference between biology and psychology, this difference
sense. The inner travel is something that develops one as a
must be thought of in terms of different causal pathways to
person, makes one wiser, a bit like what the Bildungsreise
similar end conditions. But why, then, is it better to bring
to Italy was supposed to do for a young nobleman in the
about the same thing by way of self-work instead of taking
a pill? There are a few possible answers here, some bad
This brings us to a fourth answer to why psychotherapy
could be better than antidepressants in the process of self-change. In a course of psychotherapy (at least in a goodone) one is offered the opportunity not only to change
Ethically relevant differences between psychotherapy
oneself, but also to answer the question of who one wants
to be. Existential matters enter the psychotherapeutic ses-sion, whereas they do not play a significant role in
Let us start with the bad ones. A standard answer from a
treatment with antidepressants.16 Now, again, I think this
psychotherapist—I think—would be that psychotherapy
need not be entirely true. The example of Tess shows us
has effects on the deep layers of the self, whereas the self-
that the change effected by the antidepressant can be linked
change of Tess is really cosmetic: it is taking place on the
to self-reflection and life choices in a fundamental way.
surface and is not reaching through to the deep, true layers
And nor is it certain that all psychotherapies offer the
of Tess’s personality. I think this is obviously wrong; the
opportunity for these kinds of reflections. A cognitive-
temperament is a deep-seated disposition of the self, which
based therapy cure often resembles more a mind-set change
is not a mere surface, and in many senses is fundamental to
programme than a reflective process, especially if it is set
who we are. Moreover, the temperament, in contrast to the
up over the Internet or is brought about by way of a self-
mere views and opinions of a person, is very hard to
help book. An important difference between psychophar-
change; it is deeply ingrained, fundamental to our self
macological treatment and psychotherapeutic treatment,
formation.15 It is true that the temperament is certainly not
nevertheless, is that the latter is (or should be) fundamen-
all there is to our personality: habits, skills, memories,
tally dialogic in its form. Meetings with a psychotherapist
preferences, character and many other things are also basic
offer better opportunities for life-issue reflections than the
to the phenomenon of self (Goldie ). But the tem-
brief encounters with the consulting psychiatrists and
perament represents basic strata of personality formation,
general practitioners who are prescribing SSRIs.
which many of the other traits depend on, and it is therefore
Why is it important that psychotherapy offers, not only a
way to change yourself in the sense of relieving painful
Another possible way to defend the ethical significance
symptoms related to your mood-profile, but also a reflec-
of the difference might be that it is always better to bring
tive process involving the question of who you want to be?
about a self-change by oneself, in contrast to having it done
Because the changes in temperament need the whole per-
by something other. It is not clear what this means, exactly.
sonality-formation process (involving existential, ethical
Taking a pill is also of course something I do, at least if I
reflection) in order to be stable and complete. The self is
do it of my free will. Perhaps the relevant difference is that
more than its temperament, and a substantial, lasting self-
psychotherapy is more demanding, more laborious, but
change should take into consideration the character strata
why, then, are laborious things always better? If I save
of the self too, which may very well involve the personal
energy by not entering psychotherapy, maybe I can use that
history of how we became who we are. If the temperament
energy on something that is better, not only for myself, but
is a basic disposition to be ‘mooded,’ attuned in different
ways in your being-in-the-world, the character is a basic
The most promising way, I think, to make the difference
disposition to think and give reasons for acting in certain
between psychological self-work and pills ethically rele-
ways that you think are the key to what a person should do
vant is to point out that there is more to the process of self-
in various circumstances (Goldie ). The character
change than the goal. Perhaps the path is the goal in some
involves explicit ethical stands and choices, whereas thetemperament is only an attuned predisposition to enter (ornot enter) into moral reflection in different ways. This is
15 At this point the psychotherapist might protest that the changes she
the important difference between temperament and char-
is effecting, by way of listening and talking to the client, are changes
acter: the temperament will admittedly play an important
in the unconscious meaning formations of the clients life. This is whythey are deep changes rather than shallow ones. Such claims are hard
role in the formation of a personality, but what the
to defend, however, since there appears to be no convincing empiricalevidence for the meta-psychology and changes in question. The trickything is that unconscious changes, by definition, can never be directly(but only indirectly) verified, even by the person who is assumedly
16 Regarding the existential aspects of becoming oneself within the
context of new medical technologies, see Christiansen
The ethics of self-change: becoming oneself by way of antidepressants or psychotherapy?
personality (person) essentially becomes is rather the sum
Sometimes SSRIs help in effecting temperament changes
of its character (and other personality) traits.17
that are lasting in the sense that they do not go away when the
That psychotherapy to a much larger extent involves the
patient is taken off medication. Often this way of becoming
whole profile of the self in its attempts to effect a change is
oneself is a regaining of oneself; that is, the person says that
an important aspect when one compares it with drug
the medication has brought back her old self, and not brought
treatment. Nevertheless, it must be stressed that people
about a ‘new’ self in the way that Tess bears witness to
who visit psychotherapists want change, often changes that
(Svenaeus ). But it can be hard to terminate medication
are tied to depressive or anxious symptoms, which in turn
when antidepressants have a good effect. Patients relapse
are tied to temperament characteristics. These changes can
into their old painful feelings. Antidepressants are pre-
be hard to bring about through self-work, and increased
scribed for much longer periods today, in comparison with
self-knowledge does not guarantee the change in question.
the mid-nineties when Kramer wrote his book, and the rec-
To face one’s sorrow, boredom and anxiety in discussing
ommendation to doctors is to be rather generous faced with
the memories that they bring up might lead to change, but it
the risk of new depressive periods. As a consequence of this,
is far from certain. On the other hand, the temperament
more and more people are taking antidepressants on a per-
changes of pharmacological treatment may remain alien
manent basis. Is this a bad thing? Well, it could be,
and unstable if they are not brought up for reflection and
considering the possible side effects which afflict some
coupled to a more inclusive self-change mission. Patients
patients, things such as decreased appetite, dry mouth,
who testify that they feel better on SSRIs but nevertheless
sweating, nausea, dizziness, constipation, sleeping problems
feel less of themselves are a sharp illustration of this.
and decreased sex drive, and it could especially be a bad
Let me come back to the story of Tess, since it raises
thing considering the risk of more severe side effects in the
two further fundamental issues in comparing antidepres-
long run (Healy ). Such long-term effects of SSRIs have
sants with psychotherapy than the ones we have already
not yet been discovered, but the history of pharmaceutics
dealt with. After about nine months Kramer tries to take
teaches us to be careful, and the drugs have only been on the
Tess off medication. At first everything seems to go fine;
Tess is not quite as sharp, energetic and free of care as she
One last thing deserves to be mentioned in considering
was on the medication, but neither is she driven by the guilt
the long-term effects of antidepressants in comparison with
and obligation of the time before. But then:
psychotherapy. The characteristic change in temperamentstyle brought about by antidepressants appears to be par-
After about eight months off medication, Tess told
ticularly well suited to the New York environment in which
me she was slipping. ‘‘I’m not myself,’’ she said.
Kramer and Tess lead their lives. Shyness, modesty, and
New union negations at her work place were under
self-forgetting caring for others appear to have no place in
way, and she felt she could use the sense of stability,
this cultural milieu; they are considered pathologies rather
the invulnerability to attack that Prozac gave her.
than the virtues they might be considered to be in another
Here was a dilemma for me. Ought I provide medi-
kind of society. If I am right in claiming that antidepres-
cation to someone who was not depressed? I could
sants are bringing about a significant change in the self of
give myself reason enough—construe it that Tess was
persons, we have to take into account the consequences of
sliding into relapse, which perhaps she was. In truth, I
such changes on a collective level, given the frequent
assumed I would be medicating Tess’s chronic con-
prescriptions of these drugs in our society today. Temper-
dition, call it what you will: heightened awareness of
ament change by way of medication has a looping effect
the needs of others, sensitivity to conflicts, residual
that makes its outcome even more dramatic.18 When cer-
damage to self-esteem—all odd indications for
tain aspects of our personalities are relabelled pathologies,
medication. I discussed the dilemma with her, but
the pressure to change these kinds of temperament styles
then I did not hesitate to write the prescription. Who
increases. It will be even harder to feel at home with being
was I to withhold from her the bounties of science?
melancholic or shy if the message is that you should fix it
Tess responded again as she had hoped she would,
by way of pills the way your neighbour or colleague at
with renewed confidence, self-assurance, and social
work has already done. Nevertheless, let us not forget that
melancholy and shyness are rarely praised and self-willedby the persons who are melancholic and shy. As Kramer
17 I am using the terms of self, person and personality interchange-
puts it, who are we to withhold from them the bounties of
ably here. Admittedly persons (selves) have personalities rather than
being them, but the theme of self-change I am investigating in thisarticle is not connected to the question about which creatures areselves and which are not, but to the question of how persons change
18 Regarding such looping effects of new medical diagnoses and
In this article I have explored the ethically relevant differ-
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ences between bringing about self-change by way of
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Faut-il se traiter en prévention du MAM ? L’acétazolamide est un diurétique de la famille des sulfamides. Il est donc contre-indiqué chez les patients allergiques aux sulfamides et chez les patients atopiques aux multiples allergies en l’absence de certitude quant à l’innocuité de son utilisation. Dénomination internationale : Acétazolamide. Diamox® en France, Allemagne,
7. The only amino acid that does not need to enter the A site before entering the P site on a ribosome during the process of translation is methionine. Methionine is coded for by AUG, the start codon, and therefore it is always the first amino acid in a newly synthesized polypeptide. Since it is the first amino acid, there will be no amino acid before it to form a peptide bond with and hence it n