Chapter 12: Standard Therapy of Chronic Hepatitis C Virus Infection By Markus Cornberg, Benjamin Maasoumy, Svenja Hardtke, Kerstin Port, Michael P. Manns, Heiner
Table 11. Overview of drug interactions of HCV-PIs with frequently used co-medications.
Drug class Suspected Effect of Co- Recommendation for Alternatives without administration Management interactions Analgesics Acetylsalicylic acid Buprenorphine Ibuprofen Morphine Paracetamol Pethidine
monitoring Dose adjustments may be needed
Antiarrhytmics Atenolol Metoprolol
close/cautious monitoring (amiodarone drug levels); Should be avoided
carefully titrated, starting with the lowest dosage. Close/cautious monitoring
BOC: Very close/cautious monitoring (Quinidine drug levels); Should be avoided
TLV: Contraindicated BOC: Should be avoided
Antibiotics Aminoglycosides Azithromycin Ciprofloxacin Linezolid Meropenem Moxifloxacin Rifaximin Streptomycin Trimethoprim/ Sulfamethoxazole Vancomycin Anticoagulants Anticonvulsants Gabapentin Lamotrigine Levetiracetam Valproate
levels May alter phenobarbital levels (TLV)
Antidepressants Clomipramine Fluvoxamine Imipramine Nortriptyline
monitoring Dose adjustments may be needed
monitoring Dose adjustments may be needed
Antifungals Amphotericin B Flucytosine
Daily dose of itraconazole should not exceed 200mg/d
ECG) Daily dose of ketoconazole should not exceed 200mg/d
Antihypertensiv Atenolol Furosemide Losartan Metoprolol Nebivolol Ramipril Spironolacton Antimigraine Rizatriptan Antiprotozoals Atovaquone Pyrimethamine Antipsychotics/ Olanzapine Neuroleptics Anxiolytics/ Lorazepam Hypnotics/ Oxazepam Sedatives
Parenteral: Very close monitoring; lower dosage (50%); Should be avoided
Erectile Dysfunction
dose must not exceed 25 mg every 48 hours; TLV: Should be avoided
monitoring; vardenafil dose must not exceed 2.5 mg every 24 hours; TLV: Should be avoided
Gastrointestinal Esomeprazole Omeprazole Pantoprazole Azathioprine suppressants
Dose adjustments needed; Very close/cautious monitoring
Statines Use statin with least interaction (Pravastatin)
recommended; Daily dose must not exceed of 40mg; TLV: Contraindicated
Steroids Beclometasone
adjustments; Very close/cautious monitoring; Should be avoided
not reliable. Use two effective non-hormonal methods.
Tamsulosin May increase Closer/cautious tamsulosin levels monitoring
Increased levels = increased cmax and/or prolonged time for elimination (AUC) References: EMA. Incivo; Summary of product characteristics. 2012:
LA LIBERTAD RELIGIOSA, CAMINO PARA LA PAZ 1. AL COMIENZO DE UN NUEVO AÑO deseo hacer llegar a todos mi felicitación; es un deseo de serenidad y de prosperidad, pero sobre todo de paz. El año que termina también ha estado marcado lamentablemente por persecuciones, discriminaciones, por terribles actos de violencia y de Pienso de modo particular en la querida tierra de Iraq, que en su cam
Technisch Informatieblad Stand: Augustus 2002 EMBASOL HOUTWORMDOOD 1. Productbeschrijving Reukloos en kleurloos houtverduurzamingsmiddel op basis van oplosmiddelen voor het bestrijden van houtaantastende insecten. Embasol Houtwormdood is een bestrijdingsmiddel met een laag risico voor mens en warmbloedige dieren. Toelatingsnummer Werkzame stof Embasol Houtwormdood is toe te