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CURRICULUM VITAE

PERSONAL INFORMATIONS:
Domenico Bosco
Birth date : 13.11.1960, Avellino, Italy
Nationality: Swiss
Marital status : single
Address: Ch. des Palettes, 7. 1212 Grand-Lancy, Geneva, Switzerland.
CURRENT POSITION:
Biologist, Cell Isolation and Transplantation Center, Department of Surgery, since 2001
Chargé d’Enseignement, Medical School, since 1998
DILPLOMAS:
1985: Diploma in Biology (Institut of Histology and Embryology, Medical School, University of
Geneva, Geneva)
1991: Ph.D. (Department of Morphology, Medical School, University of Geneva, Geneva )
EDUCATION:
1981: Baccalaureat (Collège Rousseau, Geneva)
1985: Diploma in Biology (Institut of Histology and Embryology, Medical School, University of
Geneva, Geneva)
1986-1991: Ph.D. (Department of Morphology, Medical School, University of Geneva,
Geneva)
RESEARCH POSITIONS:
1992-1997: Maître-assistant in the Department of Morphology (Medical School, University of
Geneva, Geneva)
1997-2001: Maître-assistant in the Laboratoires de Recherche Louis-Jeantet (Medical
School, University of Geneva, Geneva)
Since 2001: Biologist in the Laboratory of Cellular Transplantation, Department of Surgery
(Geneva)
TEACHING APPOINTMENTS:
Since 1986:
Practicals and courses in histology and embryology, for medical students of University of Geneva Person in charge for the organisation of the ”Cranio-Facial Unit” organized for medical students in the University of Geneva Courses on epithelia, for medical students of University of Geneva PUBLICATIONS:

Peer reviews
IF = Impact Factor
•
Huarte J., Belin D., Bosco D., Sappino A.-P. and Vassalli J.-D. Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface. J. Cell Biol. (1987) 104, 1281-1289. IF 12.023. Meda P., Bruzzone R., Chanson M., Bosco D. and Orci L. Gap junctional coupling modulates secretion of exocrine pancreas. Proc. Natl. Acad. Sci. U.S.A. (1987) 84, 4901-4904. IF 10.272. Bosco D., Chanson M., Bruzzone R. and Meda P. Visualization of amylase secretion from individual pancreatic acini. Am. J. Physiol. (1988) 254, G664-G670. IF 3.421. Bosco D., Orci L. and Meda P. Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells. Exp. Cell Res. (1989) 184, 72-80. IF 3.949. Chanson M., Bruzzone R., Bosco D. and Meda P. Effects of n-alcohols on junctional coupling and amylase secretion of pancreatic acinar cells. J. Cell. Physiol. (1989) 139, 147-156. IF 5.463. Meda P., Bosco D., Chanson M., Giordano E., Vallar L., Wollheim C. and Orci L. Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells. J. Clin. Invest. (1990) 86, 759-768. IF 14.307. Bosco D. and Meda P. Actively synthesizing B-cells secrete preferentially after glucose stimulation. Endocrinology (1991) 129, 3157-3166. IF 5.063. Giordano E., Bosco D., Cirulli V., and Meda P. Repeated glucose stimulation reveals distinct and lasting secretion patterns of individual pancreatic B-cells. J. Clin. Invest. (1991) 87, 2178-2185. IF 14.307. Meda P., Chanson M., Pepper M., Giordano E., Bosco D., Traub O., Willecke K., El Aoumari A., Gros D., Beyer E. C., Orci L. and Spray D. In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells. Exp. Cell Res. (1991) 192, 469-480. IF 3.949. Soria B., Chanson M., Giordano E., Bosco D., and Meda P. Ion channels of glucose-responsive and unresponsive B-cells. Diabetes (1991) 40, 1069-1078. IF 8.298. Vassalli J.-D., Huarte J., Bosco D., Sappino A.-P., Sappino N., Velardi A., Wohlwend A., Erno H., Monard D. and Belin D. Protease-nexin I as an androgen-dependent secretory product of the murine seminal vesicle. EMBO J. (1993) 12, 1871-1878. IF 10.456. Giordano E., Cirulli V., Bosco D., Rouiller D., Halban P. and Meda P. B-cell size influences glucose-stimulated insulin secretion. Am. J. Physiol. (1993) 256, C358-C364. IF 4.103. Bosco D., Soriano J.V., Chanson M. and Meda P. Heterogeneity and contact-dependent regulation of amylase release by individual acinar cells. J. Cell. Physiol. (1994) 160. 378-388. IF 5.463. Bosco D., Meda P., Thorens B. and Malaisse W. J. Heterogenous secretion of individual B cells in response to D-glucose and to nonglucidic secretagogues. Am. J. Physiol. (1995) 268, C611-C618. IF 4.103. Thorens B., Dériaz N., Bosco D., DeVos A., Pipeleers D., Schuit F., Meda P. and Porret A. Protein kinase A-dependent phosphorylation of GLUT2 in pancreatic cells. J. Biol. Chem. (1996) 271, 8075-8081. IF 6.482. Vozzi C., Bosco D., Dupont E., Charollais A. and Meda P. Hyperinsulinemia-induced hypoglycemia enhanced by overexpression of Cx43. Endocrinology: (1997) 138, 2879-2885. IF 5.069. Labarthe M.-P., Bosco D., Saurat J.-H., Meda P. and Salomon D. Upregulation of connexin 26 and connexin 43 between keratinocytes of psoriatic lesions. J. Invest. Dermatol. (1998) 111, 72-76. IF 4.194. Meyer K., Irminger J.-C., Moss L.G., Moitoso de Vargas L., Oberholzer J., Bosco D., Morel P. and Halban P.A. Sorting human -cells consequent to targeted expression of green fluorescent protein (GFP). Diabetes (1998) 47, 1974-1977. IF 8.298. Chanson M., Fanjul M., Bosco D., Nelles E., Suter S., Willecke K. and Meda P. Enhanced secretion of amylase from exocrine pancreas of connexin32-deficient mice. J. Cell Biol. (1998) 141, 1267-1275. IF 12.023. Charollais A., Serre V., Mock C., Cogne F., Bosco D. and Meda P. Loss of 1 connexin does not alter the prenatal differentiation of pancreatic -cells and leads to the identification of another islet cell connexin. Dev. Genetics (1999) 24, 13-26. IF (2000) 3.220. Bosco D., Meda P., Halban P.A. and Rouiller D.G. Importance of cell-matrix interactions in rat islet b-cell secretion in vitro: role of 6 1 integrin. Diabetes (2000) 49, 233-243. IF 8.298. Bosco D., Meda P. and Iynedjian P.B. Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization. Biochem. J. (2000) 348: 215-222. IF 4.101. Charollais A., Gjinovci A., Huarte J., Bauquis J., Nadal A., Martin F., Andreu E., Sanchez-Andrés J., Calabrese A., Bosco D., Soria B., Wollheim C.B., Herrera P.L. and Meda P. Junctional communication of pancreatic b cells contributes to the control of insulin secretion and glucose tolerence. J. Clin. Invest. (2000) 106: 235-243. IF 14.307. Bosco D., Gonelle-Gispert C., Wollheim C.B., Halban P.A. and Rouiller D.G. Increased intracellular calcium is required for spreading of rat islet -cells on extracellular matrix. Diabetes (2001) 50: 1039-1046. IF 8.298. Ris F., Hammar E., Bosco D., Pilloud C., Maedler K., Donath M. Y., Oberholzer J., Zeender E., Morel P., Rouiller D. and Halban P. A. Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro. Diabetologia (2002) 45: 841-850. IF 5.689. Toso C., Oberholzer J., Ceausoglu I., Ris F., Rochat B., Rehor A., Bucher P., Wandrey C., Schuldt U., Belenger J., Bosco D., Morel P. and Hunkeler D. Intra-portal injection of 400-µm microcapsules in a large-animal model. Transplant. Int. (2003) 16: 405-410. IF 1.204. Toso C., Berney T., Oberholzer J., Chave J.-P., Martin P.-Y., Zeender E., Bosco D. and Morel P. Kidney-Pancreas Transplantation in a long-term non-progressor HIV-infected recipient. Am. J. Transplant. (2003) 3: 631-633. IF 5.678. Toso C., Morel P., Bucher P., Shapiro J., Mathe Z., Demuylder-Mischler S., Bosco D., Berney T., Philippe J. and Oberholzer J. Insulin independence after conversion to tacrolimus and sirolimus-based immunosuppression in islet-kidney recipients. Transplantation (2003) 76: 1133-1134. IF 3.608. Maedler K., Sergeev P., Ehses J.A., Mathe Z., Bosco D., Beney T., Dayer J.-M., Reinecke M., Halban P.A. and Donath M. Leptin modulates cell expression of IL-1 receptor antagonist and release of IL-1 in human islets. Proc. Natl. Acad. Sci. USA (2004) 101: 8138-8143. IF 10.272. Hammar E., Parnaud G., Bosco D., Perriraz Nadja, Maedler K., Donath M., Rouiller D.G. and Halban P. Extracellular matrix protects pancreatic -cells against apoptosis: role of short- and long-term signalling pathways. Diabetes (2004) 53: 2034-2041. IF 8.298. Bucher P., Mai G., Mathe Z., Bosco D., Pernin N., Berney T., Morel P. and Buhler L. Retransplantation of discordant xenogeneic islets with costimulatory blockade. Transplant. P. (2004) 36:1201-1202. IF 0.588. Mathe Z., Bucher P., Bosco D., Andres A., Fux C., Toso C., Oberholzer J., Wandrey C, Sainz-Vidal D, Espinosa D., Buhler L., Morel P. and Berney T. Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally. Transplant. P. (2004) 36:1199-1200. IF 0.588. Bucher P., Mathe Z., Bosco D., Oberholzer J., Toso C., Andres A., Buhler L., Morel P. and Berney T. Microbial surveillance during human pancreatic islet isolation. Transplan.t P. (2004) 36: 1147-1148. IF 0.588. Bucher P., Bosco D., Mathe Z., Matthey-Doret D., Andres A., Kurfuerst M., Ramsch-Gunther N., Buhler L., Morel P. and Berney T. Optimization of neutral protease to collagenase activity ratio for islet of Langerhans isolation. Transplant. P. (2004) 36:1145-1146. IF 0.588. Bucher P., Mathe Z., Bosco D., Andres A., Kurfuerst M., Ramsch-Gunther N., Buhler L., Morel P. and Berney T. Serva collagenase NB1: a new enzyme preparation for human islet isolation. Transplant. P. (2004) 36:1143-1144. IF 0.588. Berney T., Mathe Z., Bucher P., Demuylder-Mischler S., Andres A., Bosco D., Oberholzer J., Majno P., Philippe J., Buhler L. and Morel P. Islet autotransplantation for the prevention of surgical diabetes after extended pancreatectomy for the resection of benign tumors of the pancreas. Transplant. P. (2004) 36:1123-1124. IF 0.588. Berney T., Bucher P., Mathe Z., Andres A., Bosco D., Mage R., Toso C., Oberholzer J., Becker C., Philippe J., Buhler L. and Morel P. Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations. Transplant. P. (2004) 36:1121-1122. IF 0.588. Bucher P., Mathe Z., Bosco D., Becker C., Kessler L., Greget M., Benhamou P.Y., Andres A., Oberholzer J., Buhler L., Morel P. and Berney T. Morbidity associated with intraportal islet transplantation. Transplant. P. (2004) 36:1119-1120. IF 0.588. Zeender E., Maedler K., Bosco D., Berney T., Donath M.Y. and Halban P.A. Pioglitazone and sodium salicylate protect human -cells against apoptosis and impaired function induced by glucose and IL-1 . J. Clin. Endocr. Metab. (2004) 89: 5059-5066. IF 5.873. Bucher P., Mathe Z., Morel P., Bosco D., Andres A., Kurfuerst M., Friedrich O., Raemsch-Guenther N., Bühler L.H. and Berney T. Assessment of a novel two-component enzyme preparation (collagenase NB1) for human islet isolation and transplantation. Transplantation (2004) 79: 91-97. IF 3.608. Toso C., Zaidi H., Morel P., Armanet M., Andres A., Pernin N., Baertschiger R., Slosman D., Bühler L., Bosco D. and Berney T. Positron-emission tomography imaging of early events after transplantation of islets of Langerhans. Transplantation (2005) 79: 353-355. IF 3.608. Bucher P., Oberholzer J., Bosco D., Mathe Z., Toso C., Bühler L., Berney T. and Morel P. Microbial surveillance during human pancreatic islet isolation. Transplant Int. 18: 584-589. IF 2.049. Moriscot C., de Fraipont F., Richard M.J., Marchand M., Savatier P., Bosco D., Favrot M. and Benhamou P.Y. Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Stem Cells (2005) 23: 594-604. IF 5.802. Kempf M.-C., Andres A., Morel P., Benhamou P.-Y., Bayle F., Kessler L., Badet L., Thivolet C., Penformis A., Renoult E., Brun J.-M., Atlan C., Renard E., Colin C., Milliat-Guittard L., Pernin N., Demuylder-Mischer S., Toso C., Bosco D. and Berney T. on behalf of the GRAGIL group. Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation. Transplantation (2005) 79: 1200-1205. IF 3.608. Andres A., Toso C., Morel P., Bosco D., Bucher P., Oberholzer J., Mathe Z., Mai G., Wekerle T., Berney T. and Bühler L. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. Transplantation (2005) 79: 543-549. IF 3.608. Toso C., Mathe Z., Morel P. Oberholzer J., Bosco D., Sainz-Vidal D., Hunkeler D, Buhler L.H., Wandrey C. and Berney T. Effect of microcapsule composition and short term immunosuppression on intraportal biocompatibility. Cell Transplant. (2005) 14: 159-167. IF 2.327. Maedler K., Carr R. D., Bosco D., Zuellig R. A., Berney T. and Donath M. Y. Sulfonylurea induced -cell apoptosis in cultured human islets. J. Clin. Endocrinol. Metab. 90 (2005): 501-506. IF 5.447. Mai G., Bucher P., Morel P., Mei J., Bosco D., Andres A., Mathe Z., Wekerle T., Berney T. and Bühler L.H. Anti-CD154 mAb treatment but not recipient CD154 deficiency leads to long-term survival of xenogeneic islet grafts. Am. J. Transpl. (2005) 5: 1021-1031. IF 5.678. Andres A. Toso C., Morel P., Demuylder-Mischler S., Bosco D., Baertschiger R., Pernin N., Bucher P., Majno P.E., Bühler L.H. and Berney T. Impact of a Sirolimus/Tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation. Transplant. P. (2005) 37: 1326-1327. IF 0.588. Mai G., Huy N.T., Morel P., Mei J., Bosco D., Berney T., Majno P., Mentha G., Trono D. and Bühler L.H. Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes. Transplant. P. (2005) 37: 527-529. IF 0.588. Andres A., Toso C., Morel P., Bosco D., Bucher P., Oberholzer J., Mathe Z., Mai G., Wekerle T., Berney T. and Bühler L.H. Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation. Transplant. P. (2005) 37: 463-465. IF 0.588. Mai G., Bucher P., Morel P., Mei J., Bosco D., Andres A., Mathe Z., Wekerle T:, Berney T. and Bühler L.H. Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets. Transplant. P. (2005) 37: 460-462. IF 0.588 Bosco D., Meda P., Morel P., Matthey-Doret D., Caille D., Toso C., Bühler L.H. and Berney T. Expression and secretion of alpha 1- proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells. Diabetologia (2005) 48: 1523-1533. IF 5.689. Parnaud G., Hammar E, Rouiller D.G. and Bosco D. Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion. Am. J. Physiol. Endocrinol. Metab. (2005) 289: E313-E321. IF 3.828. Hammar E.B, Irminger J.-C. Rickenbach K., Parnaud G., Ribaux P., Bosco D., Rouiller D.G. and Halban P. A. Activation of NF-kB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells. J. Biol. Chem. (2005) 280: 30630-30637. IF 6.482. Mai G., Huy N.T., Morel P., Mei J., Andres A., Bosco D., Baertschiger R., Toso C., Berney T., Majno P., Mentha G., Trono D. and Buhler L.H. Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes. Xenotransplantation (2005)12: 457–464. IF 2.437. Parnaud G., Hammar E.B., Rouiller D.G., Armanet M., Halban P.A. and Bosco D. Blockade of integrin beta1-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix. Diabetes (2006) 55: 1413-14-20. IF 8.298. Toso C., Baertschiger R., Morel P., Bosco D., Armanet M., Wojtusciszyn A., Badet L., Philippe J., Becker C. D., Hadaya K., Majno P., Bühler L., Berney T. and the GRAGIL group. Sequential kidney/Islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol. Am J Transpl. (2006) 6: 1049-1058. IF 5.678. Maedler K., Schumann D.M., Schulthess F., Oberholzer J., Bosco D., Berney T. and Donath M.Y. Aging Correlates With Decreased {beta}-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1. Diabetes (2006) 55:2455-2462. IF 8.298. Berney T., Mamin A., James Shapiro A.M., Ritz-Laser B., Brulhart M.C., Toso C., Demuylder-Mischler S., Armanet M., Baertschiger R., Wojtusciszyn A., Benhamou P.Y., Bosco D., Morel P. and Philippe J. Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control. Am J Transplant. (2006) 6: 1704-1711. IF 5.678. Mathe Z., Dupraz P., Rinsch C., Thorens B., Bosco D., Zbinden M., Morel P., Berney T. and Pepper M.S. Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation. Cell Transplant. (2006) 15: 621-636. IF 3.482. Maedler K., Schumann D.M., Sauter N., Ellingsgaard H., Bosco D., Baertschiger R., Iwakura Y., Oberholzer J., Wollheim C.B., Gauthier B.R. and Donath M.Y. Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes (2006) 55: 2713-22. IF 7.955. Badet L., Benhamou P.Y., Wojtusciszyn A., Baertschiger R., Milliat-Guittard L., Kessler L., Penfornis A., Thivolet C., Renard E., Bosco D., Morel P., Morelon E., Bayle F., Colin C., Berney T. and GRAGIL Group. Expectations and strategies regarding islet transplantation: metabolic data from the GRAGIL 2 trial. Transplantation (2007) 84: 89-96. IF 3.641. Bosco D., Rouiller D.G. and Halban PA. Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity. J Endocrinol. (2007) 194: 21-9. IF 2.636. Schumann D.M., Maedler K., Franklin I., Konrad D., Storling J., Boni-Schnetzler M., Gjinovci A., Kurrer M.O., Gauthier B.R., Bosco D., Andres A., Berney T., Greter M., Becher B., Chervonsky A.V., Halban P.A., Mandrup-Poulsen T., Wollheim C.B. and Donath M.Y. The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A (2007) 104: 2861-6. IF 9.598. Parnaud G., Bosco D., Berney T, Pattou F, Kerr-Conte J, Donath MY, Bruun C, Mandrup-Poulsen T., Billestrup N. and Philippe A. Halban. Proliferation of sorted human and rat beta-cells. Diabetologia (2008) 51: 91-100. IF 5.822. Toso C., Vallee J.-P., Morel P., Ris F., Demuylder-Mischler S., Lepetit-Coiffe M., Marangon N., Saudek F., Shapiro A.M.J., Bosco D. and Berney T. Clinical Magnetic Resonance Imaging of pancreatic islet grafts after iron nanoparticle labelling. Am J Transplant. (2008) 8: 701-706. IF 6.423. Baertschiger R.M., Bosco D, Morel P., Serre-Beinier V., Berney T., Buhler L.H. and Gonelle-Gispert C. Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development. Pancreas (2008) 37: 75-84. IF 2.300. Wojtusciszyn A., Armanet M., Morel P., Berney T. and Bosco D. Insulin secretion from human beta-cells is heterogeneous and dependent on cell-to-cell contacts. Diabetologia (2008) 51:1843-1852. IF 5.822. Niclauss N., Sgroi S, Morel P., Baertschiger R., Armanet M., Wojtusciszyn A., Parnaud G., Muller Y., Berney T. and Bosco D. Computer-assisted digital image analysis to quantify the mass and purity of isolated human islets prior to transplantation. Transplantation (2008) 86: 1603-1609. IF 3.641. Serre-Beinier V., Bosco D., Zulianello L., Charollais A., Caille D., Charpantier E., Gauthier BR., Diaferia GR, Giepmans BN, Lupi R., Marchetti P., Deng S., Buhler L., Berney T., Cirulli V. and Meda P. Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression. Human Molecular Genetics (2009) 18: 428-439. IF 7.249. Hammar E., Tomas A., Bosco D. and Halban PA. Role of the Rho-Rock (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta cell function. Endocrinology (2009) 150: 2072-2079. IF 4.945. Baertschiger R.M., Serre-Beinier V., Morel P., Bosco D., Peyrou M., Clément S., Sgroi A., Kaelin A., Buhler L.H. and Gonelle-Gispert C. Fribrogenic potential of human multipotent mesenchymal stromal cells in injured liver. Plos One (2009) 4: e6657. Wojtusciszyn A., Andres A., Morel P., Charvier S., Armanet M., Toso C., Choi Y., Bosco D. and Berney T. Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantation. Transpl Int. (2009) 22: 931-939. IF 3.115. Armanet M., Wojtusciszyn A., Morel P., Parnaud G., Rousselle P., Sinigaglia C., Berney T., Bosco D. Regulated laminin-332 expression in human islets of Langerhans. FASEB Journal (2009), in press, IF 7.049. Belin D., Huarte J., Vassalli A., Sappino A.-P., Bosco D., Strickland S. and Vassalli J.-D. Plasminogen activators in mouse gametes: a molecular analysis. In "Development and function of the reproductive organs", Parvinen M., Huhtaniemi I. and Pell. (1988). Meda P., Bruzzone R., Chanson M. and Bosco D. Junctional coupling and secretion of pancreatic acinar cells. In "Gap Junctions", Hertzberg E.L. and Johnson R.G., Eds., Modern Cell Biology (1988). Vol. 7, pp. 353-364, Alan R. Liss, Inc., New York. Bruzzone R., Chanson M., Swenson K. I., Bosco D., Meda P. and Paul D.L. Gap junctions and cell-to-cell signalling. In "Cell Signalling: Experimental Strategies", Reid E, Cook G.M.W. and Luzio J.P., Eds., (1991) pp. 341-358, Royal Society of Chemistry, Cambridge. Meda P., Bosco D., Giordano E. and Chanson M. Junctional coupling modulation by secretagogues in two cell pancreatic systems. In "Biophysics of gap junction channels", Peracchia C., Ed., (1991) pp. 191-208, CRC press, Inc., Boca Raton. Meda P., Vozzi C., Ullrich S., Dupont E., Charollais A., Sutter E. and Bosco D. Gland cell connexins. Progr. Cell Res. (1995) 4, pp. 281-287. Bosco D. and Meda P. Reconstructing islet function in vitro. Adv. Exp. Med. Biol. (1997) 426, 285-298. Bosco D. and Meda P. Assessing release of secretory products from individual cells. In “Animal Cell Culture Techniques Springer Lab Manual”, Clynes M., Ed., (1998) pp. 197-216, Springer-Verlag, Berlin. Bosco D. and Meda P. Search for the gap junction-permeant signals that potentiate secretion of -cells in contact. In “Gap Junctions”, Werner R., Ed, (1998) pp. 153-157, IOS Press, Amsterdam. Meda P. and Bosco D. Communication of islet cells: molecules and functions. In "Molecular Basis of Pancreas Development and Function", Habener JF and Hussain MA, Eds, (2001) pp. 143-163, Kluger Academic Publishers, Norwell. Berney T., Mathe Z., Bucher P., Andres A., Bosco D., Toso C., Bühler L. et Morel P. Autotransplantation d’îlots de Langerhans pour la prevention du diabète après resection pancréatique étendue. Médecine et Hygiène (2003) 2442, pp. 1313-1318. Bucher P., Mathe Z., Bosco D., Andres A., Bühler L.H., Morel P. and Berney T. Islet of Langerhans transplantation for the treatment of type 1 diabetes. Swiss Surg. (2003) 9: 242-246. Bosco D., Chanson M. and Meda P. Direct visualization of amylase release heterogeneity from individual pancreatic acini. Digestion (1987) 38, 7. Meda P., Chanson M., Bosco D. and Orci L. Influence of gap junctional communication on exocrine pancreatic secretion. Acta Anat. (1987)128, 342. Chanson M., Bruzzone R., Trautmann A., Randriamampita C., Bosco D. and Meda P. Parallel regulation of amylase release and cell-to-cell communication. Digestion (1987) 38, 10. Meda P. and Bosco D. Actively synthesizing B-cells secrete preferentially after glucose stimulation. Diabetologia (1989) 32, 516A. Meda P., Chanson M. and Bosco D. Gap junctional communication in the control of peptide secretion. In Vitro Toxicol. (1990) 3, 111-112. Meda P., Bosco D., Vozzi C. and Ullrich S. Roles of gap junctional communication in differentiated cell systems. Eur. J. Cell Biol. (1992) 36, suppl. 57, 52. Bosco D. and Meda P. Individual cell-to-cell contacts rapidly recruit pancreatic B-cells for glucose-induced insulin secretion. (1993) 54ème réunion annuelle de la Société Suisse d'Anatomie, d'Histologie et d'Embryologie, Fribourg, Suisse. Bosco D. and Meda P. Individual contacts rapidly recruit pancreatic B-cells for glucose-induced insulin secretion. First International Meeting of The Pancreatic Islet Study Group, (1993) Alicante, Spain. Dupont E., Bosco D. and Meda P. Tight junctions and associated proteins between endocrine pancreatic islet cells. 54ème réunion annuelle de la Société Suisse d'Anatomie, d'Histologie et d'Embryologie, (1993) Fribourg, Suisse. Meda P., Vozzi C., Ullrich S. and Bosco D. Glucose-unresponsive insulin-producing cells are defective in gap junction coupling and show improved secretion after Cx43 transfection. First International Meeting of The Pancreatic Islet Study Group, (1993) Alicante, Spain. Salomon D., Masgrau E., Vischer S., Dupont E., Bosco D., Saurat J.H. and Meda P. In vivo modulation of connexin expression in human epidermis by all-trans retinoic acid. International meeting on gap junctions. (1993) Hiroshima, Japan. Vozzi C., Ullrich S., Bosco D., Dupont E. and Meda P. Defective coupling of glucose -unresponsive insulin-producing cells and correction by Cx43 transfection. International meeting on gap junctions. (1993) Hiroshima, Japan. Vozzi C., Ullrich S., Bosco D., Dupont E. and Meda P. Glucose-unresponsive insulin-producing cells show defects in gap junction and improved secretion after Cx43 transfection. 54ème réunion annuelle de la Société Suisse d'Anatomie, d'Histologie et d'Embryologie, (1993) Fribourg, Suisse. Bosco D and Meda P. Early glucose metabolites mediate the increased insulin secretion of -cells in contact. Union des Sociétés Suisses de Biologie Expérimentale. 29 ème Assemblée annuelle, (1997) Genève, Suisse, A87. Chanson M., Fanjul M., Bosco D., Nelle E., Willecke K. and Meda P. Communication via connexins and pancreatic secretion. Union des Sociétés Suisses de Biologie Expérimentale. 29 ème Assemblée annuelle, (1997) Genève, Suisse, A82. Mock C., Bosco D. and Meda P. Loss of Cx43 does not impair the foetal morphogenesis of pancratic islets. Union des Sociétés Suisses de Biologie Expérimentale. 29 ème Assemblée annuelle, (1997) Genève, Suisse, A86. Bosco D. and Meda P. Early glucose metabolites permeating gap junctions potentiate the insulin secretion of -cells in contact. 1997 International Gap Junction Conference, (1997) Key Largo, Florida, USA. Chanson M., Fanjul M., Bosco D., Nelle E., Willecke K. and Meda P. Enhanced secretion of amylase from pancreatic acinar cells in connexin32-deficient mice. 1997 International Gap Junction Conference, (1997) Key Largo, Florida, USA. Bosco D., Halban P.A. and Rouiller D.G. Role of 1 integrins in spreading and function of rat islet -cells. Diabetologia (1998) 41, Suppl. 1, A66. Bosco D., Halban P.A. and Rouiller D.G. Differential effect of secretagogues on adhesion receptors of rat islet B-cells. Diabetologia (1999) 42, Suppl. 1, A150. Meda P., Charollais A., Gjnovci A., Calabrese A., Wonkam A, Caton D., Wisznievski L., Serre V., Cogne F., Bauquis J., Bosco D., Huarte J., Herrera P. Altered -cell coupling results in abnormal insulin secretion and glucose tolerance in vitro. Diabetologia (1999) 42, Suppl. 1, A46. Bosco D., Halban P.A., Gonelle-Gispert C., Wollheim C.B. and Rouiller D.G. Secretagogue-induced spreading of rat pancreatic beta cells: role of cytosolic calcium. Diabetologia (2000) 43, Suppl. 1, A136. Ris F., Hammar E., Molinette M. Bosco D., Oberholzer J., Morel P., Rouiller D. and Halban P. Survival in culture of purified human -cells and their expression of integrins. Diabetologia (2000) 43, Suppl. 1, A56. Bosco D., Zeender E, Bucher P., Mathe Z., Halban P.A., Berney T., Bühler L., Morel L. and Oberholzer J. Expression and secretion of alpha-1 proteinase inhibitor from human non-beta islet cells. Diabetologia (2002) 45, Suppl. 2, A143. Bosco D., Halban P.A., and Rouiller D.G. Rat beta-cells expression of cell adhesion molecules (CAMs): effect of glucose on E-cadherin expression and correlation with insulin secretion. ELSO Proceedings (2002), Nice, France. Hammar E., Parnaud G., Bosco D., Maedler K., Halban P. A. and Rouiller D.G. 804G matrix protects primary beta cells against apoptosis, induces increased expresson of IkBa and activates Akt/PKB. ADA (American Diabetes Association) 63rd Scientific Sessions (2003), New Orleans, Louisiana, USA. Toso C., Zaidi H., Morel P., Armanet M., Andres A., Pernin N., Baertschiger R., Bosco D., Bühler L., Slosman D. and Berney T. Imaging of early post-islet transplant events by positron emission tomography (PET). XX International Congress of the Transplantation Society (2004), Vienna. Austria. Mathe Z., Langer R.M., Jaray J. Filo A., Doros A., Weszelits V., Remport A., Varga M., Mathe Zs, Perner F., Andres A., Bosco D., Morel P. and Berney T. Human pancreatic islet transplantation in international collaboration with a distant islet isolation center: preliminary results from the Budapest-Geneva experience. XX International Congress of the Transplantation Society (2004), Vienna. Austria. Andres A., Toso C., Morel P., Demuylder-Mischler S., Bosco D., Bucher P, Mathe Z., Baertschiger R., Bühler L. and Berney T. Renal function impairment after islet transplant alone (ITA) or islet-after-kidney (IAK) transplantation using a sirolimus-tacrolimus-based regimen. XX International Congress of the Transplantation Society (2004), Vienna. Austria. Andres A., Toso C., Morel P., Bosco D., Bucher P., Oberholzer J., Mathe Z., Weckerle T., Berney T. and Bühler L. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. XX International Congress of the Transplantation Society (2004), Vienna. Austria. Kempf M.-C., Andres A., Morel A., Benhamou P.-Y., Toso C., Baertschiger R., Pernin N., Bosco D., Bühler L., Berney T. Logistics and transplantation coordination activity in the gragil swiss-french multicenter network of islet transplantation. XX International Congress of the Transplantation Society (2004), Vienna. Austria. Berney T., Toso C., Andres A., Demuylder-Mischler S., Bosco D., Baertschiger R., Bucher P., Mathe Z., Becker C., Philippe J., Martin P.-Y. and Morel P. Insulin independence in islet after kidney allogeneic transplantation using a steroid-free protocol. XX International Congress of the Transplantation Society (2004), Vienna. Austria. Mathe Z., Dupraz P., Zbinden M., Bosco D., Filo A., Bucher P., Rinsch C., Thorens B., Berney T. and Pepper M.S. Regulated gene expression of VEGF-164 by pancreatic beta-cells improves revascularization and engraftment after transplantation. 40th Annual Meeting of the European Association for the Study of Diabetes (2004), Munich, Germany. Diabetologia (2004): 47, suppl. 1, A181. Sigrist S., Rieger L., Mandes K., Bohbot A., Bosco D., Berney T., Pinget M and Kessler L. Human pancreatic islet rejection during transplantation: the role of chemokine signalling pathway. 40th Annual Meeting of the European Association for the Study of Diabetes (2004), Munich, Germany. Diabetologia (2004): 47, suppl. 1, A181. Maedler K., Schumann D.M., Bosco D., Iwakura Y. and Donath M.Y. Interleukin-1 is a physiological regulator of -cell proliferation and secretory function. 40th Annual Meeting of the European Association for the Study of Diabetes (2004), Munich, Germany. Diabetologia (2004): 47, suppl. 1, A157. Halban P.A., Maedler K., Zeender E., Bosco D., Berney T. and Donath M.Y. Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and IL-1b. 40th Annual Meeting of the European Association for the Study of Diabetes (2004), Munich, Germany. Diabetologia (2004): 47, suppl. 1, A174. Parnaud G., Hammar E., Rouiller D.G. and Bosco D. Inhibition of calpain blocks rat pancreatic beta-cell spreading and insulin secretion. 40th Annual Meeting of the European Association for the Study of Diabetes (2004), Munich, Germany. Diabetologia (2004): 47, suppl. 1, A170. Hammar E., Irminger J.-C., Ribaux P., Parnaud G., Bosco D., Rickenbach K., Maedler K., Donath M., Rouiller D.G. and Halban P.A. Activation of NF-kappaB by extracellular matrix in primary rat pancreatic beta cells. 40th Annual Meeting of the European Association for the Study of Diabetes (2004), Munich, Germany. Diabetologia (2004): 47, suppl. 1, A163. Ribaux P., Hammar E., Parnaud G., Rouiller D., Bosco D. and Halban P. Anti-apoptotic effect of extracellular matrix on rat primary beta cells involves b1 integrins and signalling via PKB, ERK and FAK. 40th Annual Meeting of the European Association for the Study of Diabetes (2004), Munich, Germany. Diabetologia (2004): 47, suppl. 1, A40. Gonelle C., Baertschiger R.M., Morel P., Nowak N., Kindler V., Bosco D., Serre-Beinier V. and Buhler L. Study of human mesenchymal stem cells and their potential to differentiate into hepatocytes.7th Congress of the International Cell Transplant Society (2004), Boston, USA. Baertschiger R.M., Buhler L., Morel P., Nowak N., Kindler V., Bosco D., Serre-Beinier V. and. Gonelle C. Study of human mesenchymal stem cells and their potential to differentiate into hepatocytes. Keystone Symposia: Molecular Regulation of Stem Cells (2005), Banff, Alberta, Canada. Baertschiger R.M., Bühler L., Morel P., Bosco D., Wojtusciszyn A., Armanet M., Nowak N., Serre-Beinier V., Berney T. and C. Gonelle-Gispert. Adult human exocrine pancreas contains mesenchymal stem cells. 10th World Congress of International Pancreas and Islet Transplant Association (2005), Geneva, Switzerland. Baertschiger R.M., Wojtusciszyn A., Morel P., Bosco D., Armanet M., Andres A., Mathe Z., Bucher P., Pernin N., Charvier S., Toso C. and Berney T. How to select good donors of pancreatic islets? A difficult task. American Transplant Congress (2005), Seattle, USA. Hammar E.B., Irminger J.-C., Rickenbach K., Parnaud G., Ribaux P., Bosco D., Rouiller D.G. and Halban P.A. Extracellular matrix-induced NF- B activity in pancreatic beta cells is involved in spreading, actin cytoskeleton remodelling and glucose-stimulated insulin secretion. 41th Annual Meeting of the European Association for the Study of Diabetes (2005), Athens, Greece. Diabetologia (2005): 48, suppl. 1, A26. Brun T., Duhamel D., Sarret E.J., Bosco D., Wollheim C.B. and Gauthier B.R. The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by glucose, activin A and betacellulin. 41th Annual Meeting of the European Association for the Study of Diabetes (2005), Athens, Greece. Diabetologia (2005): 48, suppl. 1, A27. Parnaud G., Hammar E., Rouiller D.G., Halban P.A. and Bosco D. Blockade of integrin 1-laminin 5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix. 41th Annual Meeting of the European Association for the Study of Diabetes (2005), Athens, Greece. Diabetologia (2005): 48, suppl. 1, A163. Baertschiger R.M., Bühler L., Morel P., Bosco D., Wojtusciszyn A., Armanet M., Nowak N., Serre-Beinier V., Berney T. and Gonelle-Gispert C. Adult human exocrine pancreas contains mesenchymal stem cells. 3rd Congress of the International Society for Stem Cell Research (2006), San Francisco, USA. Baertschiger R.M., Bühler L., Morel P., Nowak N., Kindler V., Bosco D., Serre-Beinier V. and Gonelle-Gispert C. Albumin expression is induced in human mesenchymal stem cells co-cultured with hepatocellular carcinoma cells. 3rd Congress of the International Society for Stem Cell Research (2006), San Francisco, USA. Wojtusciszyn A., Toso C., Morel P., Baertschiger R., Armanet M., Kempf M.-C., Badet L., Bosco D., and Berney T. on the behalf of the GRAGIL group. Transplantation d’îlots après rein: l’obtention d’une insulino indépendance n’est pas à n’importe quel prix. ALFEDIAM 2006. Wojtusciszyn A., Andres A., Morel P., Charvier S., Armanet M., Bosco D. and Berney T. Le rôle de la voie TRANCE dans un modèle murin de stimulation WojtusciszynA. , Armanet M., Morel P., Baertschiger R., Berney T. and Bosco D. La sécrétion d’insuline par les cellules beta humaines est hétérogène. ALFEDIAM 2006. Wojtusciszyn A., Toso C., Morel P., Armanet M., Baertschiger R., Badet L., Bosco D. and Berney T. Insulin-independence after sequential kidney/islet transplantation using steroid-free immunosuppression. The Transplantation Society, 8th International Congress of the Cell Transplant Society (2006), Milano, Italy. Wojtusciszyn A., Armanet M, Morel P., Baertschiger R., Berney T. and Bosco D. Insulin secretion from human beta cells is heterogeneous. The Transplantation Society, 8th International Congress of the Cell Transplant Society (2006), Milano, Italy. Wojtusciszyn A., Andres A., Morel P., Charvier S., Armanet M., Bosco D., Bühler L. and Berney T. Role of TRANCE pathway in a mouse allogeneic stimulation model. The Transplantation Society, 8th International Congress of the Cell Transplant Society (2006), Milano, Italy. Armanet M., Baertschiger R., Morel P., Wojtusciszyn A., Bosco D. and Berney T. Islet Extracellular Matrix Stimulates Inflammatory Mediator Secretion by Macrophages. The Transplantation Society, 8th International Congress of the Cell Transplant Society (2006), Milano, Italy. Berney T., Wojtusciszyn A., Kessler L., Badet L., Penfornis A., Bayle F., Thivolet, Renard C.E., Renoult E., Milliat-Guittard L., Colin C., Oberholzer J., Bosco D., Baertschiger R., Armanet M., Sgroi A., Morel P. and Benhamou P.-Y., GRAGIL Group. Results of islet transplantation in type 1 diabetic patients in the swiss-french gragil consortium according to immunosuppression (is), indication and islet shipment. World Transplant Congress 2006. Wojtusciszyn A., Toso C., Morel P., Demuydler-Mischler S., Armanet M., Baertschiger R., Sgroi A., Bosco D. and Berney T. Response to arginine stimulation test predicts islet of Langerhans graft outcome. World Transplant Congress 2006. Armanet M., Wojtusciszyn A., Morel P., Baertschiger R., Berney T. and Bosco D. Islet extracellular matrix is a potential activator of macrophages. Annual Meeting of the European Association for the Study of Diabetes (2006), Amsterdam, Copenhagen, Denmark. Diabetologia (2006): 49, suppl. 1, 289. Parnaud G., Bosco D., Berney T., Halban P. Extracellular matrix increase rat but not human beta cell proliferation. Annual Meeting of the European Association for the Study of Diabetes (2006), Amsterdam, Copenhagen, Denmark. Diabetologia (2006): 49, suppl. 1, 295. Bosco D., Morel P., Matthey-Doret D. and Berney T. The effect of E-cadherin engagement on human beta-cell survival and function. Annual Meeting of the European Association for the Study of Diabetes (2007), Amsterdam, The Netherlands. Diabetologia (2007): 50, suppl. 1, S14. Serre-Beinier V., Toso C., Morel P., Gonelle-Gispert C., Bosco D., Bühler L. and Berney T. Macrophage migration inhibitory factor (MIF) plays an important role in the maintenance of glucose homeostasis. Annual Meeting of the European Association for the Study of Diabetes (2007), Amsterdam, The Netherlands. Diabetologia (2007): 50, suppl. 1, S27. Milliat-Guittard L., Kessler L., Wojtusciszyn A., Berney T., Badet L., Penformis F., Thivolet C., Renard E., Bosco D., Baertschiger R., Morelon E., Bayle F., Colin C and Benhamou P.-Y. Pancreatic islet allotransplantation improves the quality of life in brittle type 1 diabetic patients. Annual Meeting of the European Association for the Study of Diabetes (2007), Amsterdam, The Netherlands. Diabetologia (2007): 50, suppl. 1, S202. Wojtusciszyn A., Armanet M., Morel P., Bosco D. and Berney T. IL-1ra increases size and function of islets of Langerhans in vivo. Annual Meeting of the European Association for the Study of Diabetes (2007), Amsterdam, The Netherlands. Diabetologia (2007): 50, suppl. 1, S186.

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