For more information about the organization of teratology information specialists
For more information about the Organization of Teratology Information
Specialists or to find a service in your area, call (866) 626-6847 or visit
us online at: www.OTISpregnancy.org.
Bupropion (Wellbutrin®) and Pregnancy
This sheet talks about the risks that exposure to bupropion can have during pregnancy. With each pregnancy, all
women have a 3% to 5% chance of having a baby with a birth defect. This information should not take the place
of medical care and advice from your health care provider.
What is bupropion?
Does bupropion use increase the risk for
depression and seasonal affective disorder. It is
marketed under the trade name Wellbutrin®.
more often in pregnant women taking bupropion
Bupropion is also sold under the trade name
Zyban® as an aid to quit smoking. Bupropion
medication. However, the rate of miscarriage in
belongs to the class of antidepressants known as
women taking bupropion was not above what is
considered to be the background rate for
(NDRI), which help balance the levels of
norepinephrine and dopamine in the brain.
Can taking bupropion during my pregnancy
I am taking bupropion, but I would like to stop
cause birth defects?
taking it before becoming pregnant. How long
does bupropion stay in my body?
association between first trimester exposure and a
While it can vary from person to person,
particular heart defect. The design of this study
it generally takes about 12 hours to eliminate half
does not allow a conclusion to be drawn. In
of the drug from the body. Bupropion is almost
contrast,the manufacturer’s pregnancy registry
completely gone from the body in three days.
reported there was not an increased risk for major
Pregnant women who suddenly stop taking their
birth defects among over 1,000 pregnancies with
antidepressants are at risk for physical and
first trimester exposure to bupropion. Other
studies involving over 1,300 pregnancies exposed
to bupropion in the first trimester also showed no
nervousness or anxiety. If a woman plans to stop
increase in the rates of birth defects when
taking her bupropion, it is recommended that this
be done slowly over time. If you are considering
Therefore, it is unlikely that using bupropion
coming off your treatment with bupropion, please
during pregnancy would increase the risk for
talk with your doctor to decide if the benefits of
not taking this medication during pregnancy
outweigh the risk of your symptoms returning.
Should I stop taking bupropion when I find out
I am pregnant? What about weaning off
Can bupropion make it more difficult for me to
bupropion before the third trimester?
Infertility was not seen in rat studies.
depression, there are reports of increased risk for
There are no studies that look specifically at
miscarriage and preterm delivery, as well as
fertility in women taking bupropion. Two cases
babies born with complications and low birth
have been reported of irregular menstrual cycles
weight. Untreated depression in pregnancy can
linked to bupropion use. However, these case
continue after delivery as postpartum depression,
reports did not mention fertility problems.
which is a serious condition that should be
or babies with other complications. More studies
are needed to better focus on this area.
decision of whether or not to stop antidepressant
the amount of milk their bodies make. If you
therapy. If you choose to stop your medication,
your doctor can help you wean off it in a slow
What if the father of the baby takes bupropion?
There are no studies looking at possible
I need to take bupropion throughout my entire
risks to a pregnancy when the father takes
pregnancy. Will it cause withdrawal symptoms
bupropion. In general, medications that the father
in my baby?
is exposed to would not increase the risk to a
pregnancy because the father does not share a
exposure to bupropion and withdrawal symptoms
blood connection with the developing baby. For
in babies. Some infants whose mothers took other
more information, please see the OTIS fact sheet
antidepressants near the end of pregnancy have
had withdrawal symptoms like irritability,
difficulties. These symptoms usually go away
within a few days to two weeks. It is important to
decide with your doctor whether the treatment of
depression with bupropion offsets the risk of
Will taking bupropion have any long-term effect
on my baby’s behavior and development?
Alwan S, et al. 2010. Maternal use of bupropion and risk of congenital heart defects.
term effects on children exposed to bupropion
Baab S, et al. 2002. Serum bupropion levels in 2 breastfeeding mother-infant pairs. J Clin Psych 63:910-911.
during pregnancy. One study has suggested an
Chun-Fai-Chan B, et al. 2005. Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 192(3):932-
bupropion and attention deficit hyperactivity
disorder (ADHD). There are many factors that
Cole A, et al. 2006. Bupriopion in pregnancy and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf 10.1002/pds.1296.
contribute to ADHD and further study is needed
before a conclusion can be made. Presently, we
Einarson T and Einarson A. 2005. Newer Antidepressants in pregnancy and rates of major malformations: a meta-analysis of prospective comparative studies.
pregnancy would have any long term effects on
Figueroa R. 2010. Use of antidepressants during pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring. J Dev Behav Pediatr 31(8):641.
Glaxo Wellcome Bupropion Pregnancy Registry 9/1/97 - 8/31/06. Issued December 2006. Research Park, Wilmington, North Carolina.
Can I take bupropion while breastfeeding?
Haas J, et al. 2004. Bupropion in breast milk: an exposure assessment for potential
Please talk to your doctor if you need to
treatment to prevent post-partum tobacco use. Tob Control 13:52-56.
take bupropion while breastfeeding. Bupropion is
Halbreich U, et al. 1991. Menstrual irregularities associated with bupropion treatment. J Clin Psych 52:15-16.
found in breast milk. A mother taking the
recommended dosage of bupropion passes only a
2004. Neonate characteristics after maternal use of antidepressants in late pregnancy. Arch Pediatr Adolesc Med 158(4):312-3016.
Kalra S, et al. 2005. Motherisk Update: Taking depressants during late pregnancy. Can
Breastfeeding while taking bupropion should not
Nonacs R, et al. 2005. Bupropion SR for the treatment of postpartum depression: a pilot
study. Int J Neuropsychopharmacol 8(3):445-9.
individuals prone to them. There is a report of
one baby exposed to bupropion through breast
milk who then had seizures. The seizures stopped
If you have questions about the information on
when the mother stopped taking bupropion. The
this fact sheet or other exposures during
small amount of bupropion passed through breast
pregnancy, call OTIS at 1-866-626-6847.
milk may have more impact on premature infants
Minutes of the City Council The regular meeting of the City Council was held Tuesday, September 14, 2010. President Edward R Podmanik called the meeting to order at 7:03 PM. THE INVOCATION WAS GIVEN BY: Council Chaplin, Kay Fantauzzi, who, then led in the Pledge of Allegiance. ********************** ROLL CALL OF MEMBERS ******************* Present: Podmanik, Rosso, Smith, Kovach, Bri
REZA FARID HOSSEYNI, MD, DTCT, FAAAAI 55 Nastran Ave. Nasteran 8 Mashhad, Iran firstname.lastname@example.org Home: 0098 511 761 15 80 Cell: 0098 915 111 13 80 Fax: 0098 511 761 06 81 Intrested Research : HTLV-1 , Allergic disease Adjunct Professor of Allergy Health Promotion Sciences Adjunct Professor of Immunology College of Medicine . The University Of Arizona Mel and Enid Zuckerman College of Public