November , 200

2nd Scientific Meeting of
Asia-Pacific Diabetes and Obesity Study Group
Information and Program

1. Dates:

Saturday, August 26-Sunday, August 27, 2006
2. Venue:

Meeting: “Taketori-no-ma”, 5th floor
Poster presentation and Welcome reception: “Kokin-no-ma”, 5th floor
901 Higashi-Shiokoji-cho, Shiokoji Sagaru Karasuma-Dori Shimogyo-ku, Kyoto 600-8216 Japan TEL: +81 (0)75 344 8888 FAX: +81 (0)75 344 4400
3. Organized

Organizing Committee of Asia-Pacific Diabetes and Obesity Study Group
4. Sponsored
5. Secretariat:
Secretariat of 2nd Scientific Meeting of Asia-Pacific Diabetes and Obesity Study Group Komiya Bldg. 3rd floor, 1-4-15 Nihonbachi Honcho 6. Official
English is the working language of the meeting
7. Attire:
Business casual attire is appropriate for all functions.

8. Registration:
Registration desk is open from 14:00 on August 26 on the 5th floor.
9. Accommodation:
Your accommodation is reserved at Hotel Granvia Kyoto.
Please kindly note that hotel check-in and check-out time are as follows;
Check-in time 15:00 Check-out time 12:00 Hotel will try to accommodate for the early arrivals, but cannot guarantee early check-in. Check-in and check-out should be done at the hotel reception, not at the meeting registration desk. Confirmation for the accommodation as well as for the ground transportation will be sent to you by our official agency, JTB. 10. Program:

Saturday, August 26

Masato Kasuga, Japan
Session 1: APDO Study Group Lecture 1
David James, Australia

Session 2: Oral Presentation
<10min presentation 5min Q&A session each>
co-chairs: Garth
Cooper, New Zealand and Davis Ng, Singapore

[Oral 2-1]
Regulation of hepatic glucose metabolism Seung-Hoi Koo, Korea
Brain insulin action regulates hepatic glucose production via STAT3 signaling in the liver Wataru Ogawa, Japan
Bruce Kemp, Australia
Melanocortin peptides signal to regulate appetite, body weight and metabolism. Kathleen Mountjoy, New Zealand



Session 3: Oral Presentation
<10min presentation 5min Q&A session each>
co-chairs: Youfei
Guan, China and Karen SL Lam, Hong Kong
Forkhead transcription factor FoxO1 in brown adipose tissue regulates energy expenditure through regulation of Pgc-1a and 4E-BP1 expression Jun Nakae, Japan
Involvement of apolipoprotein E in excess fat accumulation and insulin resistance Yasushi Ishigaki, Japan
Skp2 plays an essential role in adipocyte proliferation during the development of obesity Hiroshi Sakaue, Japan
Down-regulation of HDACs Stimulates adipocyte differentiation Jae Bum Kim, Korea
Role of IRS-1 serine phosphorylation in the regulation of insulin signaling and glucose transport Young-Bum Kim, Korea
Session 4: Poster presentations & Refreshments
Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice Won Keun Oh, Korea
The role of adipose glycerol channel; aquaporin adipose/7 Norikazu Maeda, Japan
Pioglitazone improves insulin sensitivity by increasing adiponectine secretion from fat tissue via reduced expression of SOCS3 Isao Usui, Japan
[P-4] Uncoupling protein 2 promoter polymorphism -866G/A affects peripheral nerve dysfunction in Hiroshi Yamasaki, Japan
Obesity and late-onset diabetes in the mice lacking Sqstm1/p62 associate with mitochondrial dysfunction Jaekyoon Shin, Korea
Expression of glutathione peroxidae 3 gene is regulated by peroxisome proliferator-activated receptor Kyong Soo Park, Korea
Overall and early stage hypertrophy of b-cells in humans with type 2 diabetes Jae-Hyoung Cho, Korea
AMPK action; cell cycle progression and cell death in glucolipotoxicity Ji-Won Kim, Korea
[P-9] The participation of PKCζ in insulin-medicated glucose transport in rat skeletal muscle L6 Peter Tong, HongKong
human Insulin-like growth factor binding protein-3 in transgenic tobacco Peter Tong, HongKong
Welcome Reception

Sunday, August 27


sponsored by Takeda Pharmaceutical Company Limited


Session 5: APDO Study Group Lecture 2
James, Australia
Takashi Kadowaki, Japan
Session 6:
Oral Presentation
<10min presentation 5min Q&A session each>
co-chairs: Tao
China and Greg Cooney, Australia
From QTL to candidate gene; A story told by a diabetes mouse model Huei-Ju Pan, Taiwan
Diabetes protein signature in human serum revealed by label-free and pathway-associated differential proteomics Jia-Rui Wu, China
Berberine activates AMPK and has beneficial metabolic actions in diabetic and insulin resistant states Edward W Kraegen, Australia
Dissecting the role of individual isoforms of PI 3-kinase in insulin signalling Peter R Shepherd, New Zealand
Physiological function of the unfolded protein response using single target gene analysis Davis Ng, Singapore
Inhibition of PKC epsilon as a novel strategy for treatment of Type 2 diabetes, by reconstitution of glucose-induced insulin secretion and diminution of hepatic insulin clearance Trevor J Biden, Australia
Session 7:
Oral Presentation
<10min presentation 5min Q&A session each>
Jae Bum Kim, Korea and Tetsuro Izumi, Japan
Role of cyclophilin B in ER stress and insulin processing Sung Soo Kim, Korea
Upregulation of islet beta-cell fructose 1,6 bisphosphatase results in insulin secretory dysfunction Joseph Proietto, Australia
RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells Yong Liu, China
Crucial role for an evolutionarily conserved cis-regulatory region of pdx1in pancreas organogenesis and islet function Yoshio Fujitani, Japan
Inducible nitric oxide synthase (iNOS) plays an important role in hypoxic injury to pancreatic beta cells Kun-Ho Yoon, Korea

Lunch (photo session)
Session 8:
Invited Lecture
Systems analysis of mitochondrial dysfunction in human diabetes Vamsi K. Mootha, USA

Session 9:
Oral Presentation
<10min presentation 5min Q&A session each>
co-chairs: Kyung
Park, Korea and Peter Tong, Hong Kong

[Oral 9-1]
Adiponectin inversely correlates with triglyceride and high-sensitivity C-reactive protein but not with insulin or insulin resistance index in Japanese men. Mitsuhisa Komatsu, Japan
The role of the macrophage in obesity induced insulin resistance Mark Febbraio, Australia
Overexpression of Monocyte Chemoattractant Protein 1 (MCP-1) in adipose tissues causes systemic insulin resistance Nozomu Kamei, Japan



Session 10:
Oral Presentation
<10min presentation 5min Q&A session each>

co-chairs: Jon

Australia and Yoshihiro Ogawa, Japan
Adipocyte-FABP as a novel player in the metabolic syndrome: clinical and functional studies Karen SL Lam, Hong Kong

[Oral 10-2]
Elevated Circulating Concentrations of Lipocalin 2 May Contribute to Obesity-associated Ectopic Lipid Accumulation and Insulin Resistance in Mice Aimin Xu, Hong Kong

[Oral 10-3]
CXS741, A Novel Secreted Protein Involved in the Pathogenesis of Obesity and Type 2 Diabetes Ken Walder, Australia

[Oral 10-4]
Pathophysiological roles of adipokine network in metabolic syndrome Toshimasa
Closing Remarks
Takashi Kadowaki, Japan


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