Journal club schedule 2009_12

Journal Club Schedule
March ‘09 Gene replacements inT gondii lacking Ku80 (Fox et al (2009) Euk Cell 8: 520-29; Huynh and Carruthers (2009) Euk Cell 8: 530-39) “Host cell entry by apicomplexa parasites requieres actin polymerization in the host cell” Gonzalez et al (2009) Cell Host Microbe 5: 259-72. T. gondii Dynamin (van Dooren et al (2009) Current Biol 19:267-276.; Breininch et al, (2009) Current Biol 19: 277-286) “Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites” Bougdour et “Apicomplexan Parasites co-opt host calpains to facilitate their escape from infected cells”. Chandramohanadas et al (2009) Science 324: 794-7 “Rab11A-Controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis” Agop-Nersesian et al (2009) PLoS Pathogens 5: e1000270. “A newly discovered protein export machine in malaria parasites” de Koning-Ward et al (2009) Nature 459: 918. “Kinetics and Phenotype of Vaccine-Induced CD8+ T-Cell responses of Toxoplasma gondii” Jordan et al (2009) Infect Immun 77: 3894-3901. “Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis” Blume et al (2009) PNAS 106: 12998-13003. “Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells” Starnes et al (2009) Cell Host Microbe 5: 353-364. Jan 29 ‘10 “Toxoplasma gondii Infection Specifically Increases the Levels of Key Host MicroRNAs” Zeiner et al (2009) PLoS One 5: e8742. “A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite” Moon et al (2009) PLoS Pathogens 5: e1000599. “Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte” Russo et al (2010) Nature 463: 632 and “An aspartyl protease directs malaria effector proteins to the host cell” Boddey et al (2010) Nature 463: 627. “Coordinate control of host centrosome position, organelle distribution and migratory response by Toxoplasma gondii via host mTORC2” Wang et al (2010) JBC Papers in Press M109.095778. “A Plant-like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes” Dvorin et al (2010) Science 328: 910 and “Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma” Lourido et al (2010) Nature 465: 359. "Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite" Leykauf and Treeck et al. (2010) PLoS Pathogens 6:e1000941. "The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands" Zhang et al. (2010) J Exp Med 207:1465. “A Major Role for the Plasmodium falciparum ApiAP2 Protein PfSIP2 in Chromosome End Biology” Flueck et al (2010) PLoS Pathogens 6:e1000784. 2010 Molecular Parasitology Meeting review “A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division” Beck et al (2010) PLoS Pathogens 9: e1001094. “A complex small RNA repertoire is generated by a plant/fungal-like machinery and effected by a metazoan-like Argonaute in the single-cell human parasite Toxoplasma gondii”. Braun et al, PLoS Pathog. 2010 6(5):e1000920 “Functional dissection of the apicomplexan glideosome molecular architecture”. Frenal et al, Cell Host Microbe 2010 8: 343-57. “Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence”. Fentress et al, Cell Host Microbe. 2010 Dec 16;8(6):484-95. “The C-Terminus of Toxoplasma RON2 Provides the Crucial Link between AMA1 and the Host-Associated Invasion Complex”. Tyler and Boothroyd, PLoS Pathog. 2011 Feb 10:e1001282 and “The RON2-AMA1 Interaction is a Critical Step in Moving Junction-Dependent Invasion by Apicomplexan Parasites”. Lamarque et al, PLoS Pathog. 2011 Feb 10:e1001276 “The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host”. Coppi et al., J Exp Med 2011 Feb; 208(2):341-356. “Validation of isoleucine utilization targets in Plasmodium falciparum”. PNAS 2011 108: 1627-32. “A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis”. Nature Chem Biol 2011 7:375-83. “Extracellular Toxoplasma gondii tachyzoites do not require carbon source uptake for ATP maintenance, gliding motility and invasion in the first hour of their extracellular life”. IJP 2011 41: 835-841 “Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide”. Science 2011 333: 463-7 “Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii”. Mol. Bio. Cell 2011 22:1290-1299 “Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii.” J.Exp. Med 2011 208(7): 1547-1559 “Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum”. Yeh and DeRisi, PLoS Biol 2011 Aug; 9(8): e1001138. “Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites.” PLoS Path (2011) 7:e1002280. “Unusual N-glycan Structures Required for trafficking Toxoplasma gondii GAP45 to the inner membrane complex regulate host cell entry trhough parasite motility” Mol & Cell Proteomics 2011 10 (9): M111.008953 “Autophagy Protein Atg3 is Essential for Maintaining Mitochondrial Integrity and for Normal Intracellular Development of Toxoplasma gondii Tachyzoites”. PLoS Path (2011) 7: e1002416 “Multiple Peptidoglycan Modification Networks Modulate Helicobacter pylori’s Cell Shape, Motility, and Colonization Potential”. PLoS Path (2012) 8: e1002603.

“Processive Movement of MreB-Associated Cell Wall
Biosynthetic Complexes in Bacteria” Science (2011)
333: 225
“Coupled, Circumferential Motions of the Cell Wall
Synthesis Machinery and MreB Filaments in B. subtilis”
Science (2011) 333: 222.
“The fitness of drug-resistant malaria parasites in a
rodent model: multiplicity of infection” Journal of
Evolutionary Biology (2011) 24:2410-2422.
“Apicoplast Targeting of a Toxoplasma gondii Transmembrane Protein Requires a Cytosolic Tyrosine-Based Motif”. Traffic 2012; 13: 694-704. “Centromere Plasmid: A New Genetic Tool for the Study of Plasmodium falciparum”. PLoSONE (2012) 7: e33326 “Toxoplasma sortilin-like receptor regulates protein transport and is essential for apical secretory organelle biogenesis and host infection.” Cell Host Microbe (2012) 11:515-27. “Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum.” Nature 2011 480: 534-538


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