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Since there are too many papers, only those of which I am the first author are described and which are English papers. (No.) (Journals) (Volumes):(Pages-Pages), (Year) Immune deficiency states and immune imbalance in systemic lupus erythematosus and other autoimmune diseases. Clin. Immunol. Immunopathol. 12:289-300, 1979 Immunological behaviour following rubella infection. Effect of glucocorticosteroid therapy on the immune system of patients with nonimmunologically mediated dermatoses. Increased double marker lymphocytes in systemic lupus erythematosus and lymphoproliferative disorders. Y. Niwa, D.W. Ou, J.P. Waterhouse, M.M. Yokoyama, S. Miyake Studies on the dinitrochlorobenzene (DNCB) sensitization test. Y. Niwa, H. Niwa, J. Kohmura, D.W. Ou, M.M. Yokoyama Auto-oxidative damage in Behçet¶s disease ± endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils. Y. Niwa, S. Miyake, T. Sakane, M. Shingu, M. Yokoyama Effect of stimulated neutrophils from the synovial fluid of patients with rheumatoid arthritis on lymphocytes ± a possible role of increased oxygen radicals generated by the neutrophils. Y. Niwa, T. Sakane, M. Shingu, M.M. Yokoyama Enhanced neutrophilic functions in mucocutaneous lymph node syndrome, with special reference to the possible role of increased oxygen intermediate generation in the pathogenesis of coronary thromboarteritis. Transient autoantibodies with elevated complement levels in common viral diseases. Y. Niwa, T, Sakane, T. Kanoh, S. Shichijo, M.D. Wiederhold, M.M. Yokoyama Role of stimulated neutrophils from patients with systemic lupus erythematosus in disturbed immunoreactivity, with special reference to increased oxygen intermediates generated by the neutrophils. Y. Niwa, T. Sakane, M. Shingu, M. Yokoyama Dissociation of the inhibitory effect of dapsone on the generation of oxygen intermediates ± in comparison with that of colchicine and various scavengers. Decrease in generation of reactive oxygen species by neutrophils from patients with infectious mononucleosis: Role of suppressor T lymphocytes. Y. Niwa, T. Sakane, Y. Miyachi, T. Kanoh, K. Somiya Oxygen metabolism in phagocytes of leprotic patients: Enhanced endogenous superoxide dismutase activity and hydroxyl radical generation by clofazimine. Y. Niwa, T. Sakane, Y. Miyachi, M. Ozaki Phospholipid transmethylation in the membrane of human neutrophils and Methyltransferase and phospholipase A2 activity in membranes of neutrophils and lymphocytes from patients with bacterial and viral infections. Y. Niwa, T. Sakane, S. Yamamoto, T. Kanoh, S. Taniguchi Role of stimulated neutrophils from patients with systemic lupus erythematosus in tissue injury, with special reference to serum factors and increased active oxygen species generated by neutrophils. Y. Niwa, T. Sakane, M. Shingu, Y. Miyachi Reverse relationship between lysosomal-enzyme release and active-oxygen generation in stimulated human neutrophils. Y. Niwa, T. Sakane, M. Yokoyama, J.L. Skosey, Y. Miyachi Decreased oxygen radical generation by neutrophils from patients with measles presumably owing to activation of suppressor T lymphocytes. Y. Niwa, T. Sakane, K. Somiya, Y. Miyachi Neutrophil-generated active oxygens in linear IgA bullous dermatosis. Y. Niwa, T. Sakane, M. Shingu, I. Yanagida, J. Komura, Y. Miyachi Inhibitory effects of dapsone on enzymatic activities of membrane phospholipids in human blood cells. Modulation of the immunoreactivity of a T-lymphocyte subpopulation by neutrophil-released prostaglandin. Y. Niwa, T. Sakane, Y. Fukuda, Y. Miyachi, T. Kanoh Effect of liposomal-encapsulated superoxide dismutase on active oxygen-related human disorders. A preliminary study. Y. Niwa, K. Somiya, A.M. Michelson, K. Puget Antioxidant action of natural health products and Chinese herbs. Phospholipid transmethylation and choline phosphotransferase in microsomal fraction of human diseased liver. Y. Niwa, T. Sakane, M. Ichikawa, T. Kondo, S. Taniguichi Effect of cyclosporin A on the membrane-associated events in human leukocytes with special reference to the similarity with dexamethasone. Y. Niwa, T. Kanoh, S. Taniguchi, Y. Miyachi, T. Sakane Phospholipid base exchange in human leukocyte membranes: Quantitation and correlation with other phospholipid biosynthetic pathways. Arch. Biochem. Biophys. 250:345-357, 1986 Luminol-independent chemiluminescence by phagocytes is markedly enhanced by dexamethasone, not by other glucocorticosteroids. Y. Niwa, K. Somiya, Y. Miyachi, T. Kanoh, T. Sakane Detection of enhanced lipid peroxide levels in patients with inflammatory skin diseases. Y. Niwa, T. Kanoh, T. Sakane, H. Soh, S. Kawai, Y. Miyachi The ratio of lipid peroxides to superoxide dismutase activity in the skin lesions of patients with severe skin diseases: An accurate prognostic indicator. Y. Niwa, T. Kanoh, T. Sakane, H. Soh, S. Kawai, Y. Miyachi Phospholipid base exchange activity in the leukocyte membranes of patients with inflammatory disorders. Y. Niwa, T. Sakane, Y. Ozaki, T. Kanoh, S. Taniguchi The effect of aging on cutaneous lipid peroxide levels and superoxide dismutase activity in guinea pigs and patients with burns. Y. Niwa, T. Kasama, S. Kawai, J. Komura, T. Sakane, T. Kanoh, Y. Miyachi Methyltransferase and phospholipase A2 activity in the cell membrane of neutrophils and lymphocytes from patients with Behçet¶s disease, systemic lupus erythematosus, and rheumatoid arthritis. Y. Niwa, Y. Miyachi, T. Sakane, T. Kanoh, S. Taniguchi Activation of antioxidant activity in natural medicinal products by heating, brewing and lipophilization. A new drug delivery system. Y. Niwa, T. Kanoh, T. Kasama, M. Negishi Drugs Exptl. Clin. Res. 14:361-372, 1988 Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: Cross-sectional and longitudinal studies. Y. Niwa, T. Kasama, Y. Miyachi, T. Kanoh Lipid peroxides and superoxide dismutase (SOD) induction in skin inflammatory disease, and treatment with SOD preparations. Dermatologica 179(suppl. 1):101-106, 1989 Neutrophil potentiating factors released from stimulated lymphocytes: Special reference to the increase in neutrophil-potentiating factors from streptococcus-stimulated lymphocytes of patients with Behçet¶s disease. Induction of superoxide dismutase in leukocytes by paraquat: Correlation with age and possible predictor of longevity. Serum albumin metabolism in rheumatic diseases: Relationship to corticosteroids and peptic ulcer. Y. Niwa, A. Iio, G. Niwa, T. Sakane, T. Tsunematsu, T. Kanoh Why are natural plant medicinal products effective in some patients and not in the others with the same disease? Y. Niwa, Y. Miyachi, K. Ishimoto, T. Kanoh Kojic acid scavenges free radicals while potentiating leukocyte functions including free radical generation. Age-dependent basal level and induction capacity of copper-zinc and manganese superoxide dismutase and other scavenging enzyme activities in leukocytes from young and elderly adults. Y. Niwa, O. Iizawa, K. Ishimoto, H. Akamatsu, T. Kanoh Electromagnetic wave emitting products and ³Kikoh´ potentiate human leukocyte functions. Y. Niwa, O. Iizawa, K. Ishimoto, X. Jiang, T. Kanoh Abnormalities in serum lipids and leukocyte superoxide dismutase and associated cataract formation in patients with atopic dermatitis. Role of cytokines, tyrosine kinase, and protein kinase C on production of superoxide and induction of scavenging enzymes in human leukocytes. Y. Niwa, Y. Ozaki, T. Kanoh, H. Akamatsu, M. Kurisaka Clin. Immunol. Immunopathol. 79:303-313, 1996 Successful treatment of severe atopic dermatitis-complicated cataract and male infertility with a natural product antioxidant. Elevated RANTES levels in plasma or skin and decreased plasma IL-10 levels in subsets of patients with severe atopic dermatitis. Evidence for degradation of cytokines in the serum of patients with atopic dermatitis by calcium-dependent protease. Y. Niwa, H. Akamastu, H. Sumi, Y. Ozaki, A. Abe Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cerviall cancer Y. Niwa, H. Akamatsu, H. Niwa, H. Sumi, Y. Ozaki, A. Abe Plant self-defense mechanisms against oxidative injury and protection of the forest by planting trees of triploids and tetraploids Ecotoxicol. Environment. Saf., 55:70-81, 2003 Protein oxidative damage in the stratum corneum: evidence for a link between environmental oxidants and the changing prevalence and nature of atopic dermatitis in Japan Y. Niwa, H. Sumi, K. Kawahira, T. Terashima, T. Nakamura, H. Akamatsu Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin An association between ulcerative colitis and atopic dermatitis, diseases of impaired superficial barriers J. Invest. Dermatol., 123: 999-1000, 2004 Are we starting to induce skin cancer in order to avoid topical steroids? J.Eur.Acad.Dermatol.Venereol., 19: 387-389, 2005

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Prevalence of crab asthma in crab plant workers in Newfoundland and Labrador André Cartier 1, Samuel B. Lehrer 2, Lise Horth-Susin 3,Mark Swanson 4, Barbara Neis 5, Dana Howse 5, Michael Jong 5 1 Hôpital du Sacré-Coeur de Montréal2 Tulane University, New Orleans3 Valley Regional Hospital, Kentville4 Mayo Clinic5 Memorial University ABSTRACT Objectives. The aim of the study was to determine

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