ANTIDEPRESSANTS MCP-1383 A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS I. INTRODUCTION, METHODOLOGY &
Are Antidepressants Totally Safe? A Moot but
PRODUCT DEFINITIONS
Manufacturers Vociferous in their Protests.II-13
No Satisfactory Answers Yet – The Wait Grows Longer.II-13
II. EXECUTIVE SUMMARY
Global Antidepressants Market: Drug Regulation for
Kids in Britain and the United States .II-13
1. Industry Overview . II-1 3. Depression: A Mental Review . II-14
Industry Dynamics and Changing Scenario. II-2
Intense Competition in the Antidepressants Marketplace. II-2
Global Antidepressants Market (2004): Major Products
Types of Depression and Related Disorders .II-15
Major Depressive Disorders (Major Depression).II-15
Table 1: Leading Brands in the Global Antidepressants
Dysthymic Disorder (Minor Depression).II-15
Market (2001 & 2002): Sales in US$ Million for Seroxat/Paxil, Zoloft, Effexor, Cipramil/ Celexa, Wellbutrin, Prozac, Remeron, Fluoxetine Par, Serzone, and Fluoxetine Barr (include
Premenstrual Dysphoric Disorder (PMDD) .II-16
corresponding Graphs/Chart) . II-4 Table 2: Leading Drugs in the Global Antidepressants Market (2003): Sales in US$ Million for Seroxat, Zoloft, Effexor, Cipramil/ Celexa, Wellbutrin, Cipralex/ Lexapro, Prozac, and Remeron (include corresponding Graphs/Chart) .II-5
Options Available in Depression Treatment .II-17
SSRI/SNRI Brands in the Global Antidepressants Market
Psychotherapy or Psychiatric Consultation.II-17
(2002-2006): Sales in US$ Million by Geographic
Combination of Psychotherapy and Pharmacotherapy.II-17
SSRIs Garnering Major Share of the Market. II-7
Table 3: Leading Brands in the Global SSRI Antidepressants
How Can Depression Treatment become More
Market (2003): Percentage Breakdown of Value Sales for Zoloft, Paxil and Paxil CR, Generic Fluoxetine, Celexa,
Global Antidepressants Market: Favorable Drugs
Lexapro, Prozac, Prozac Weekly, and Others (include corresponding Graphs/Chart) .II-7
Global Antidepressants Market: Unfavorable
Emerging Antidepressant Classes Pose Threat to SSRI. II-8
Treatment-Resistant Depression (TRD) .II-19
2. Market Trends & Issues . II-9
New Drugs Making Way into the Market . II-9
Prozac Patent Expiry Opens Door for Generic Versions . II-9
Generic Antidepressants to Hit Market Soon . II-9
Table 4: Global Antidepressants Market (2004): Percentage Breakdown of Prevalence Rate by Disorder Type –
Westerners Fight Depression Blues; Americans
Depression, Anxiety, Obsessive Compulsive Disorder, Sleep Disorder, Panic Disorder, Phobias, and Others
Antidepressants High in Demand but Fail to Satisfy
(include corresponding Graphs/Chart) .II-20
No One is Immune: Not Even Animals!. II-11
Patent Expiry Disturbs Antidepressants Producers. II-11
Men Vs Women – Who is More Depression Prone? .II-21
Unlicensed Antidepressants Pose Danger to
Depression and Smoking – Interlinked to One Another .II-22
Global Antidepressants Market (2003): Regulations
4. Product Analysis . II-23
Governing Select Antidepressants Use in Children . II-12
What are Antidepressants? A Clear Understanding.II-23
Growing Safety Concerns – Antidepressants Under Fire . II-12
Global Antidepressants Market (2004): Select Brands
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ANTIDEPRESSANTS MCP-1383 A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS
Adverse Effects of Antidepressants and their
Select Antidepressants and their Applications . II-24
Tricyclic Antidepressants (TCAs) . II-25
Global Antidepressants Market: TCA Brands and Dosage
Types - Starting Dosage and Normal Dosage.II-25
Global Antidepressants Market: TCAs and their
Monamine Oxidase Inhibitors (MAOIs) . II-26
Side Effects Associated with Overdose .II-38
Global Antidepressants Market: MAOI Brands and Dosage
Types – Starting Dosage and Normal Dosage .II-26
Table 5: Global Antidepressants Market: Percentage
Side Effects of Different MAOIs – Tranylcypromine;
Breakdown of Volume Drug Consumption by Disorder Type – Depression, Generalized Anxiety Disorder, Post Traumatic
Selective Serotonin Reuptake Inhibitors (SSRIs). II-27
Stress Disorder, Panic Disorder and Others (include
Global Antidepressants Market: SSRIs Brands and Related
corresponding Graphs/Chart) .II-39
Do Antidepressants Treat Depression Completely?.II-40
Global Antidepressants Market: Withdrawal Symptoms
Global Antidepressants Market: Different SSRI
Antidepressants Used for Treatment of Panic
Global Antidepressants Market: SSRIs’ Off-Label
A Note of Caution for Panic Patients Using
Antidepressants Used for Treatment of Anxiety
5HT2 Receptor Antagonist Properties. II-32
Antidepressants: Causes For and Against.II-45
Antidepressants Effective in Curing Premenstrual
Antidepressants Offer Solution for Itching and
Drugs and Dosage Types - Starting Dosage
Antidepressants Offer Hope for Autistic Children.II-46
Antidepressants Minimize Hot Flushes and
Antidepressants’ Positive Effect on the Brain .II-47
Global Antidepressants Market: Major Drugs by
Longer Duration Antidepressants Treatment
Class – SSRI, SNRI, MAOI, and NaSSA. II-34
Antidepressants - A New Option for Sleep Apnea .II-47
5. Antidepressants: An In-Depth Analysis . II-35
SSRI Antidepressants May Prove Helpful in
Antidepressants, a Mere Accidental Discovery. II-35
Limited Choices and High Risk Rates . II-35
Lesser Fear of Breast Cancer with Antidepressants.II-48
Better Alternatives and Wider Choice – The New Mantra II-35
Antidepressants for Reducing Chronic Back Pain .II-48
Global Antidepressants Market: Launch of Drug Types –
TCAs, MAOI, SSRI, and New Generation Variants
Greater Heart at Risk with Antidepressants.II-48
by Original Version, Secondary Version,
Antidepressants Dissipates Sexual Drive.II-49
Hip Fractures Troubles Aged Patients .II-49
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ANTIDEPRESSANTS MCP-1383 A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS
Antidepressants can be a Deadly Prescription
Table 7: World 10-Year Perspective for Antidepressants by Geographic Region – Percentage Breakdown of
Dental Problems with Antidepressants. II-50
Dollar Sales for USA, Canada, Japan, Europe,
Facts/Myths About Antidepressants. II-50
Asia-Pacific (excluding Japan), and Latin America
Are Pregnant Women at Risk from Antidepressants? . II-50
Markets for Years 2000, 2005 & 2010 (include
Is Breast Feeding Safe While on Antidepressants?. II-51
corresponding Graphs/Chart) .II-64
Homeopathic Treatment Versus Antidepressants
Recent Findings on Antidepressants . II-52
III. MARKET 6. Technological Developments . II-53
Monitoring Technology Foresees Antidepressants
1. The United States . III-1
Vagus Nerve Stimulation - Device for Treating
Global Antidepressants Market: FDA Approvals
Antidepressants Usage in the United States .III-1
US Antidepressants Market: Drug Usage.III-2
7. Product Introductions/Innovations. II-54
GlaxoSmithKline Re-Introduces Paxil CR in US Market. II-54
Table 8:Leading Players in the US Antidepressants
Ratiopharm Launches Ratio-Paroxetine in Canada . II-54
Market (2004 & 2005(E)): Percentage Breakdown of Value Sales for Forest Labs, GlaxoSmithKline,
Apotex Releases Generic Version of Paxil. II-54
Pfizer, Wyeth, Eli Lilly and Others (include corresponding Graphs/Chart) .III-2 Table 9: Leading Players in the US SSRI/SNRI Market (2004 & 2005(E)): Percentage Breakdown of 8. Recent Industry Activity. II-56 Value Sales for Forest Labs, Pfizer, Wyeth, GlaxoSmithKline, Eli Lilly and Others
Organon in Marketing Agreement with STADA. II-56
(include corresponding Graphs/Chart) .III-3
Andrx Signs Marketing Agreement with Impax and Teva . II-56
GlaxoSmithKline Collaborates with NeuroSearch . II-56
Lundbeck in Marketing Accord with Janssen-Cilag. II-56
New Drugs Set to Conquer the Market .III-4
Lundbeck Allies with Abbott Laboratories . II-57
Myriad Signs an Agreement with Abbott Laboratories . II-57
Table 10: Leading SSRI/ SNRI Brands in the US
Recordati Obtains Marketing Rights from H Lundbeck . II-57
Antidepressants Market (2000-2005(E)): Percentage Breakdown of Sales for Prozac, Paxil, Zoloft, 9. Focus on Select Global Players . II-58 Celexa, Lexapro, Effexor and Others (include corresponding Graphs/Chart) . III-4Number of SSRI/SNRI Prescriptions Dispensed in Millions (include corresponding Graphs/Chart) . III-5Advertising Expenditure in US$ Million on Select SSRIs - Celexa (Citalopram), Prozac (Fluoxetine), Effexor XR (Venlafaxine), Zoloft (Sertraline),
Organon International, Inc. (USA) . II-60
Paxil (Paroxetine), and Luvox (Fluvoxamine) (include corresponding Graphs/Chart) .III-5
Depression More Common Among Gays .III-5
FDA Inspects Suicidal Tendencies in Kids on
10. Global Market Perspective . II-63 Table 6: World Recent Past, Current & Future Analysis for
Generic Drugs Pose Competition to Branded Drugs .III-7
Antidepressants by Geographic Region – USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin America Markets Independently Analyzed with Annual Sales Antidepressants Market (2001): Sales in US$ Million Figures in US$ Million for Years 2000 through 2010 for Zoloft, Paxil, Prozac & Sarafem, Celexa, and (include corresponding Graphs/Chart) .II-63Luvox (include corresponding Graphs/Chart) .III-7
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ANTIDEPRESSANTS MCP-1383 A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS
Depression Drugs Being Used for Symptoms Other
3. Japan. III-18
US Antidepressants Market: Drugs Approved
Frequent Patent Expiries – A Cause of Concern
Table 18: CNS Market in Japan (2001): Sales in US$
Patent Expiry of Select Antidepressant Brands
Million by Drug Class – Antidepressants, Antiulcerants, Cholesterol Reducers, Broad Antibiotic, Antiarrhythmic, Antihypertensive, Narcotic painkiller, Oral Diabetes, Oral Antihistamine, and Antiseizure (include corresponding Graphs/Chart) .III-19 Table 19: Leading Brands in the Japanese Antidepressants Market (2001 & 2002): Percentage Breakdown of Value Sales for Paxil, Luvox, Depromel, Ludiomil, Toledomin, Toledomin- Jansen, Anafranil, Tetramide, and Others (include corresponding Graphs/Chart) .III-20
Antidepressants Market in Japan – Major Drug
Table 14: US Recent Past, Current & Future Analysis for Antidepressants by Product Segment – SSRI, New Generation, TCA and MAOI Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (include corresponding Table 20: Japanese Recent Past, Current & Future Analysis for Antidepressants: Annual Sales Figures in US$ Million for Years 2000 through 2010 Table 15: US 10-Year Perspective for Antidepressants by (include corresponding Graphs/Chart) .III-22Product Segment – Percentage Breakdown of Dollar Sales for SSRI, New Generation, TCA and 4. Europe. III-23 MAOI for Years 2000, 2005 & 2010 (include corresponding Graphs/Chart) .III-14 2. Canada . III-15 Table 21: Leading Players in the European Antidepressants Market (2004 & 2005(E)) – Percentage Breakdown of Value Sales for GlaxoSmithKline, Eli Lilly, Lundbeck, Pfizer, Wyeth and Others
Increasing Use of Antidepressants among Canadian
(include corresponding Graphs/Chart) .III-24
Antidepressants Market - A Recent Past Perspective .III-15
Changes in European Patent Litigation.III-24
Percentage Breakdown of Value Sales by Class – SSRI, TCAs, MOAI, and Others (include corresponding Graphs/Chart) .III-16 Table 22: European Recent Past, Current & Future Analysis for Antidepressants by Geographic Region – France, Germany, UK, Italy, Spain, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in
Warning Against Antidepressants Use in Under-
US$ Million for Years 2000 through 2010 (include corresponding Graphs/Chart) .III-25 Table 23: European 10-Year Perspective for Antidepressants by Geographic Region – Percentage Table 17: Canadian Recent Past, Current & Future Breakdown of Dollar Sales for France, Germany, Analysis for Antidepressants: Annual Sales Figures UK, Italy, Spain, and Rest of Europe Markets for in US$ Million for Years 2000 through 2010 Years 2000, 2005 & 2010 (include corresponding (include corresponding Graphs/Chart) .III-17
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ANTIDEPRESSANTS MCP-1383 A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS 4a. France. III-27 4f. Rest of Europe . III-35 Table 24: French Recent Past, Current & Future Analysis
Focus on Select Regional Markets.III-35
for Antidepressants: Annual Sales Figures in US$ Million for Years 2000 through 2010
Danish People Display Greater Preference for
(include corresponding Graphs/Chart) .III-27 4b. Germany . III-28 Table 25: German Recent Past, Current & Future Analysis for Antidepressants: Annual Sales Figures in US$ Million for Years 2000 through 2010 (include corresponding Graphs/Chart) .III-28 4c. The United Kingdom. III-29
Table 30: Rest of Europe Recent Past, Current & Future Analysis for Antidepressants: Annual Sales Figures in US$ Million for Years 2000 through 2010 III-34 (include corresponding Graphs/Chart) .III-36
UK Bans Antidepressant Use in Children (2003) .III-29
2000): Number of Associated Deaths in England and 5. Asia-Pacific . III-37 Wales by Drug Class – TCAs, MAOIs, SSRIs and Others (include corresponding Graphs/Chart) .III-30
A Recent Past Market Perspective .III-37
Antidepressants, a Happy Pill for Sad Scots .III-30
Table 27: UK Recent Past, Current & Future Analysis Table 31: Asia-Pacific Recent Past, Current & for Antidepressants: Annual Sales Figures in Future Analysis for Antidepressants: Annual US$ Million for Years 2000 through 2010 Sales Figures in US$ Million for Years (include corresponding Graphs/Chart) .III-322000 through 2010 (include corresponding Graphs/Chart) .III-38
4d. Italy . III-33
America. III-39 Table 28: Italian Recent Past, Current & Future Analysis for Antidepressants: Annual Sales Figures in US$ Million for Years 2000 through 2010 (include corresponding Graphs/Chart) .III-33
High Usage of Antidepressants among Chileans.III-39
4e. Spain. III-34 Table 32: Latin America Recent Past, Current & Table 29: Spanish Recent Past, Current & Future Future Analysis for Antidepressants: Annual Analysis for Antidepressants: Annual Sales Figures Sales Figures in US$ Million for Years in US$ Million for Years 2000 through 2010 2000 through 2010 (include corresponding (include corresponding Graphs/Chart) .III-34
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ANTIDEPRESSANTS MCP-1383 A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS IV. COMPETITION Table 52: Nine Months Sales Analysis by Product: Table 33: Half Yearly Sales Analysis: 2004-2005 (H1) 2004-2005 (Nine Months Ended, March) Table 34: Half Yearly Sales Analysis by Segment: Table 53: Annual Sales Analysis: 2003-2004 2004-2005 (H1) (In US$ million). IV-4
Table 35: Quarterly Sales Analysis: 2003-2004 Table 54: Annual Sales Analysis by Product: 2003-2004 (In US$ million) . IV-69
Table 36: Annual Sales Analysis by Segment:
7. Boehringer Ingelheim GmbH (Germany). IV-71
2003-2004 (In US$ million) . IV-4
Table 55: Annual Sales Analysis: 2003-2004 Table 37: Annual Sales Analysis by Geographical Region: 2003-2004 (In US$ million). IV-5
Table 56: Annual Sales Analysis by Product Segment: 2003-2004 (In € million) . IV-71
2. Akzo Nobel NV (The Netherlands). IV-23
Table 57: Annual Sales Analysis by Region: Table 38: First Quarter Sales Analysis: 2003-2004 (In € million) . IV-72
2004-2005 (Q1) (In € million). IV-28
8. Bristol-Myers Squibb Co. (USA) . IV-77
Table 39: First Quarter Sales Analysis by Segment: Table 58: Annual Sales Analysis: 2003-2004 2004-2005 (Q1) (In € million). IV-28
Table 40: Annual Sales Analysis: 2002-2004 Table 59: Annual Sales Analysis by Segment: 2003-2004 (In US$ billion) . IV-79
Table 41: Annual Sales Analysis by Segment: Table 60: Annual Sales Analysis by Geographic 2003-2004 (In € million). IV-28
Region: 2003-2004 (In US$ billion). IV-79
Table 42: Annual Sales Analysis by Region:
9. Cortex Pharmaceuticals, Inc. (USA) . IV-91
2003-2004 (In € million). IV-29
10. Dr. Reddy's Laboratories Ltd. (India). IV-93
Table 61: Annual Sales Analysis: 2003-2005
Organon International, Inc. (USA). IV-36
Table 62: Annual Sales Analysis by Product Segment: 2003-2004 (In INR million). IV-95
Table 43: First Quarter Sales Analysis: Table 63: Annual Sales Analysis by Geographical 2004-2005 (Q1) (In US$ million). IV-44
Region: 2003-2004 (In INR million) . IV-95
Table 44: Annual Sales Analysis: 2003-2004 Table 64: Half Yearly Sales Analysis: Table 45: Quarterly Sales Analysis: 2003-2004 2004-2005 (H1) (In US$ million). IV-99
Table 65: Half Yearly Sales Analysis by Segment: 2004-2005 (H1) (In US$ million). IV-99
Table 66: Half Yearly Sales Analysis by Product: Table 46: First Quarter Sales Analysis: 2004-2005 (H1) (In US$ million). IV-99
2004-2005 (Q1) (In US$ billion). IV-56
Table 67: Annual Sales Analysis: 2002-2004 Table 47: First Quarter Sales Analysis by Geographic Region: 2004-2005 (Q1) (In US$ billion) . IV-57
Table 68: Annual Sales Analysis by Segment: Table 48: Annual Sales Analysis: 2003-2004 2003-2004 (In US$ million) . IV-100
Table 69: Annual Sales Analysis by Product: Table 49: Annual Sales Analysis by Therapy Area: 2003-2004 (In US$ million) . IV-100
2003-2004 (In US$ billion) . IV-57
Table 70: Annual Sales Analysis by Geographical Table 50: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million). IV-101
Region: 2003-2004 (In US$ billion). IV-57
Table 71: Quarterly Sales Analysis: 2003-2004
Astrazeneca Pharmaceuticals LP (USA). IV-66
Eli Lilly And Company Limited (UK) . IV-107
Table 51: Nine Months Sales Analysis: 2004-2005 (Nine months Ended, March) (In US$ million) . IV-68
Lilly Deutschland GmbH (Germany). IV-108
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ANTIDEPRESSANTS MCP-1383 A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS Table 92: First Quarter Sales Analysis by Geographical Table 72: First Quarter Sales Analysis: Region: 2004-2005 (Q1) (In US$ billion) . IV-149
2004-2005 (Q1) (In US$ million). IV-111
Table 93: Annual Sales Analysis: 2003-2004 Table 73: Annual Sales Analysis: 2002-2004 Table 94: Annual Sales Analysis by Segment: Table 74: Quarterly Sales Analysis: 2003-2004 2003-2004 (In US$ billion) . IV-149
Table 95: Annual Sales Analysis by Geographical
13. F. Hoffmann-La Roche Ltd. (Switzerland) . IV-112
Region: 2003-2004 (In US$ billion). IV-150
Table 75: Half Yearly Sales Analysis: Table 96: Annual Sales Analysis by Quarter: 2004-2005 (H1) (In CHF million). IV-113
2003-2004 (In US$ billion) . IV-150
Table 76: Annual Sales Analysis: 2003-2004
19. Janssen-Cilag International NV (Belgium). IV-157
Table 77: Annual Sales Analysis by Division:
21. Meiji Seika Kaisha Ltd. (Japan) . IV-160
2003-2004 (In CHF millions). IV-113
Table 97: Annual Sales Analysis: 2003-2004
14. Forest Laboratories, Inc. (USA). IV-118
Table 78: First Quarter Sales Analysis: Table 98: Annual Sales Analysis by Business 2005-2006 (Q1) (In US$ billion). IV-119
Segment: 2003-2004 (In ¥ million). IV-160
Table 79: Annual Sales Analysis: 2004-2005 Table 99: Annual Sales Analysis: 2003-2004 Table 80: Quarterly Sales Analysis: 2004-2005 Table 100: Annual Sales Analysis by Segment: Table 81: Annual Sales Analysis by Geographical 2003-2004 (In US$ Million). IV-163
Region: 2004-2005 (In US$ billion). IV-120
Table 101: Quarterly Sales Analysis: 2003-2004 Table 82: Quarterly Sales Analysis: 2003-2004
23. Mylan Laboratories, Inc. (USA). IV-165
Table 83: Annual Sales Analysis by Geographical Table 102: First Quarter Sales Analysis: Region: 2003-2004 (In US$ billion). IV-120
2005-2006 (Q1) (In US$ million). IV-166
Forest Pharmaceuticals, Inc. (USA). IV-124
Table 103: Annual Sales Analysis: 2003-2005 Table 84: Half Yearly Sales Analysis: Table 104: Annual Sales Analysis by Business 2004-2005 (H1) (In £ million). IV-126
Segment: 2004-2005 (In US$ million) . IV-166
Table 85: Half Yearly Sales Analysis by Division: Table 105: Annual Sales Analysis by Product: 2004-2005 (H1) (In £ million). IV-126
2004-2005 (In US$ million) . IV-166
Table 86: Annual Sales Analysis: 2003-2004 Table 106: Quarterly Sales Analysis: 2004-2005 Table 87: Annual Sales Analysis by Division:
24. Myriad Genetics, Inc. (USA) . IV-170
2003-2004 (In £ million). IV-126
Table 107: Annual Sales Analysis: 2003-2004 (In US$ million) . IV-171
Glaxo Smithkline Canada, Inc. (Canada). IV-139
Table 108: Annual Sales Analysis by Segment: 2003-2004 (In US$ million) . IV-171
Table 88: Annual Sales Analysis: 2002-2004 Table 89: Annual Sales Analysis by Geographical Table 109: Half Yearly Sales Analysis: Region: 2003-2004 (In DKK billion) . IV-142
2004-2005 (H1) (In US$ billion). IV-178
17. Impax Laboratories, Inc. (USA). IV-144
Table 110: Annual Sales Analysis: 2002-2004 Table 90: First Quarter Sales Analysis: Table 111: Annual Sales Analysis by Division: 2004-2005 (Q1) (In US$ billion). IV-149
2003-2004 (In US$ billion) . IV-179
Table 91: First Quarter Sales Analysis by Segment: Table 112: Annual Sales Analysis by Geographical 2004-2005 (Q1) (In US$ billion). IV-149
Region: 2003-2004 (In US$ billion). IV-179
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ANTIDEPRESSANTS MCP-1383 A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS Table 113: Quarterly Sales Analysis: 2003-2004 Table 130: Annual Sales Analysis: 2003-2004
Sandoz Deutschland GmbH (Germany). IV-190
Table 131: Annual Sales Analysis by Region: 2003-2004 (In £ million) . IV-249
28. Orion Corporation (Finland) . IV-195
Table 114: Annual Sales Analysis: 2003-2004 Table 132: First Quarter Sales Analysis: 2004-2005 (Q1) (In € million). IV-255
29. Paddock Laboratories, Inc. (USA) . IV-198
Table 133: Annual Sales Analysis: 2003-2004
30. Par Pharmaceutical, Inc. (USA) . IV-202
Table 115: First Quarter Sales Analysis: Table 134: Annual Sales Analysis by Segment: 2004-2005 (Q1) (In US$ million). IV-202
2003-2004 (In € million) . IV-255
Solvay Pharmaceutical, Inc. (USA) . IV-263
Table 116: Annual Sales Analysis: 2003-2004 (In US$ million) . IV-203
40. STADA Arzneimittel AG (Germany) . IV-265
Table 135: First Quarter Sales Analysis: Table 117: Annual Sales Analysis by Quarter: 2004-2005 (Q1) (In € million). IV-265
2003-2004 (In US$ million) . IV-203
Table 136: First Quarter Sales Analysis by Segment: 2004-2005 (Q1) (In € million). IV-266
Table 118: Half Yearly Sales Analysis: Table 137: Annual Sales Analysis: 2003-2004 2004-2005 (H1) (In US$ billion). IV-207
Table 119: Annual Sales Analysis: 2003-2004 Table 138: Annual Sales Analysis by Segment: 2003-2004 (In € million) . IV-266
Table 120: Annual Sales Analysis by Business
41. Strides Arcolab Limited (India). IV-268
Segment: 2003-2004 (In US$ billion). IV-207
42. Temmler Pharma GmbH & Co. KG (Germany). IV-271
Table 121: Annual Sales Analysis by Geographic
43. Teva Pharmaceutical Industries Ltd. (Israel) . IV-272
Region: 2003-2004 (In US$ billion). IV-207
Table 139: Half Yearly Sales Analysis:
Pfizer Australia Pty., Ltd. (Australia) . IV-221
2004-2005 (H1) (In US$ Million). IV-273
Table 140: Half Yearly Sales Analysis by Geographic Region: 2004-2005 (H1) (In US$ Million) . IV-273
Table 141: Half Yearly Sales Analysis by Business
32. Ranbaxy Pharmaceuticals, Inc. (USA). IV-229
Segment: 2004-2005 (H1) (In US$ Million). IV-274
Table 142: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ Million). IV-274
Table 122: Half-Yearly Sales Analysis: Table 143: Annual Sales Analysis by Business 2004-2005 (H1) (In € million). IV-234
Segment: 2003-2004 (In US$ Million) . IV-274
Table 123: Annual Sales Analysis: 2003-2004
44. Watson Pharmaceuticals, Inc. (USA) . IV-279
Table 144: Annual Sales Analysis: 2003-2004 Table 124: Annual Sales Analysis by Segment: 2003-2004 (In € million). IV-235
Table 145: Annual Sales Analysis by Business Segment: 2003-2004 (In US$ million). IV-280
Table 125: Annual Sales Analysis by Geographical Region: 2003-2004 (In € million). IV-235
Table 146: Half yearly Sales Analysis: 2004-2005 (H1) (In US$ million). IV-285 Table 147: Half Yearly Sales Analysis by Segment: Table 126: Half Yearly Sales Analysis: 2004-2005 (H1) (In US$ million). IV-285
2004-2005 (H1) (In € million). IV-242
Table 148: Annual Sales Analysis: 2003-2004 Table 127: Half Yearly Sales Analysis by Segment: 2004-2005 (H1) (In € million). IV-242
Table 149: Annual Sales Analysis by Segment: Table 128: Half Yearly Sales Analysis by Product: 2003-2004 (In US$ million) . IV-285
2004-2005 (H1) (In € million). IV-242
Table 150: Annual Sales Analysis by Region: Table 129: Annual Sales Analysis: 2003-2004 2003-2004 (In US$ million) . IV-285
Wyeth Australia Pty., Ltd. (Australia). IV-290
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MELD Is Superior to King’s College and Clichy’s Criteria to Assess Prognosis in Fulminant Hepatic Failure Silvina E. Yantorno, 1 Walter K. Kremers, 2 Andre ´s E. Ruf, 1 Julio J. Trentadue, 1 Luis G. Podesta Federico G. Villamil 1 1 Liver Unit, Fundacio´n Favaloro, Buenos Aires, Argentina; 2 William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN Assessment of pro
DRUG NEWS NEW DRUGS Fosamprenavir Calcium these trials, ED was associated with dia- for HIV Infection pills. Easily affixed to the skin, Climaraanticipated sexual activity. A higher dosenew protease inhibitor (PI) for the treat-diol. Estradiol is the most active estrogenwith other antiretroviral medications. necessary for patients taking other medi-cations or having medical