Michael Zemel Professor of Nutrition and Medicine Director, The Nutrition Institute The University of Tennessee 1215 W. Cumberland Avenue – Room 229 Knoxville, TN 37996-1920 865-974-6238 firstname.lastname@example.org
Education and Experience: B.S. (Nutritional Sciences), University of Wisconsin, Madison, 1976; M.S. (Nutritional Sciences), University of Wisconsin, Madison, 1978; Ph.D. (Nutritional Sciences/Physiology), University of Wisconsin, Madison, 1980. Professor of Nutrition, University of Tennessee, 1990- present; Professor of Medicine, University of Tennessee 1990-present; Head, Department of Nutrition, University of Tennessee, 1990-2002; Director, The University of Tennessee Nutrition Institute, 1994-present; Research Biochemist/Endocrinologist, VA Medical Center, Allen Park, MI 1987-1991; Associate Professor of Endocrinology, Wayne State University, Detroit, MI, 1985-1990; Assistant/Associate Professor of Nutrition and Food Science, Wayne State University, Detroit, MI, 1980-1990. Research Area Obesity and metabolic syndrome; regulation of adipocyte metabolism and of adipocyte- muscle cross-talk. Description of Research Dr. Zemel’s laboratory focuses on endocrine and nutritional modulation of mitochondrial function, energy metabolism and oxidative and inflammatory stress. This work encompasses cellular and molecular approaches to the study of adipocyte, skeletal muscle cell and macrophage metabolism and interactions, animal modelling of predicted outcomes from cellular studies, and clinical studies in obesity and the metabolic syndrome to evaluate efficacy of approaches developed in our laboratory. Current and Recent Funding Center for Disease Control 2004-2006
Principal Investigator: M.B. Zemel Obesity Prevention
National Dairy Council 2000 - 2001
Principal Investigator: M.B. Zemel The Effects of Calcium–Rich Dairy Products on Weight Loss in Obese Adults 2000 – 2003
Effects of Calcium-Rich Dairy Products on Body Composition and Weight Loss in African-American Adults 2001 - 2002
Principal Investigator: M.B. Zemel Interaction Between Calcium-Rich Dairy Products and Dietary Macronutrients in Modulating Weight Loss in aP2-Agouti Transgenic Mice 2002
Role of Whey Proteins in Enhancing the Anti-Obesity Effects of Dietary Calcium Principal Investigator: M.B. Zemel 2002-2003
Principal Investigators: J.O. Hill and M.B. Zemel Role of Dairy Products in Promoting Fat Oxidation in Humans 2002-2004
Principal Investigator: M.B. Zemel; Co-PI’s: D. Teegarden, M. Van Loan and V. Matkovic Role of Dairy Products in Weight Loss: A Multi-Center Trial 2003-2004 $239,635 Principal Investigator: M.B. Zemel Role of Dairy Products in Weight Maintenance 2005-2006
Principal Investigator: M.B. Zemel Role of Dairy Products in Weight Maintenance II (Extended Studies) 2004-2005
Principal Investigator: M.B. Zemel Role of dairy components in enhancing the anti-obesity effects of dietary calcium 2006-2007
Principal Investigator: M.B. Zemel Dietary calcium and dairy modulation of oxidative and inflammatory stress in mice 2007-2008
Principal Investigator: M.B. Zemel Dairy modulation of oxidative and inflammatory stress in overweight and obese subjects 2003-open
Principal Investigator: M.B. Zemel Dairy-Obesity Research (annual recurring unrestricted grant) 2008-2009
Principal Investigator: M.B. Zemel Dairy Attenuation of Oxidative and Inflammatory Stress in Metabolic Syndrome Bell Institute for Human Nutrition
2000 - 2001
Principal Investigator: M.B. Zemel Role of Glycemic Index in a Rodent Model of Obesity and Diabetes 2000 - 2002
Principal Investigator: M.B. Zemel Effects of Fermented Dairy Products on Body Composition and Weight Control in Transgenic Mice. 2000 – 2001
Principal Investigator: M.B. Zemel Effects of Calcium-Fortified Breakfast Cereal on Body Composition and Weight Control in a Transgenic Model of Human Obesity 2002-2003
Principal Investigator: M.B. Zemel Effects of Calcium-Fortified Breakfast Cereal on Body Composition and Weight Control in Obese Adults 2002-2003
Principal Investigator: M.B. Zemel Effects of Fermented Dairy Products on Body Composition and Weight Control in Obese Adults 2003-open
Principal Investigator: M.B. Zemel Calcium-Obesity research (annual recurring unrestricted grant) American Institute for Cancer Research 2002 – 2004
Principal Investigators: J. Whelan, M. McEntee and M.B. Zemel Prostaglandin E Receptors and Intracellular Calcium Signaling in Intestinal Tumorigenesis
Mead Johnson & Company 2005
Principal Investigator: M.B. Zemel Effects of Diet on Metabolism and Gene Expression Takanashi, Inc. 2007-2008
Principal Investigator: M.B. Zemel Effects of Milk Fermentation on the Anti-Obesity Effect of Dairy PATENTS "Calcium Fortification": Patents issued 1990 in U.S., Canada, Taiwan, Spain and several other nations. (Patent issued 6/90) US 4906,482. “Modulation of the Sulfonylurea Receptor and Calcium in Adipocytes for Treatment of Obesity/Diabetes”. (Patent issued 8/00) US 6100047. “Screening for SUR1 Antagonists Using Adipocytes” (Patent issued 6/01) US 6242200.
“Materials and Methods for the Treatment and Prevention of Obesity” (Patent issued 5/02) US 6384087. “Modulation of the sulfonylurea receptor and calcium in adipocytes for treatment of obesity/diabetes” (Patent issued 12/02) US 06492130 Zemel, et al, US Patent No. 6,384,087, issued May 7, 2002; Additional US patents for whey approved 2007, issuance pending China: Patent No. ZL01818078.7, issued May 2007 Australia, Patent No. 2001288707, issued April 2007 International: Patent Pending in Canada, European Union, Mexico, and New Zealand (PCT/US01/27432) Korea and Japan – Patent Pending (PCT/US02/40091) Selected Recent Publications: Shi H, Norman AW, Okamura A, and Zemel MB (2002) 1α,25-dihydroxyvitamin D3
inhibits uncoupling protein 2 expression in human adipocytes. FASEB J 16:1808-1810.
Zemel M.B. (2003) Mechanisms of dairy modulation of adiposity. J Nutr 133:252S-256S. Zemel, MB, Thompson, W, Milstead, A, Morris, K, Campbell, P (2004) Calcium and
dairy acceleration of weight and fat loss during energy restriction in obese adults. Obesity Research 12:582-590.
Zemel, MB (2004) Role of calcium and dairy products in energy partitioning and weight
management. Am J Clin Nutr 79:907s-912s.
Sun, X, Zemel, MB. Role of uncoupling protein 2 (UCP2) expression and 1α,25-
Dihydroxyvitamin D3 in modulating adipocyte apoptosis. FASEB J 2004; 18:130-1432
(Expanded on-line version: http://www.fasebj.org/cgi/doi/10.1096/fj.04-1971fje)
Sun, X, Zemel, MB (2004) Calcium and Dairy Inhibit Weight and Fat Regain During Ad Libitum Consumption Following Energy Restriction in Ap2-Agouti Transgenic Mice. J Nutr 134:3054-3060.
Morris, KL, Zemel, MB. (2005) 1,25-dihyroxyvitamin D3 Modulation of adipocyte
glucocorticoid function. Obesity Res; 13:670-677.
Zemel, MB, Richards J, Mathis S, et al. (2005) Augmentation of total and central fat loss
in obese subjects. Int J Obesity; 29:391-397.
Zemel, MB, Richards, J., Milstead, A. and Campbell, P. (2005) Effects of Calcium and
Dairy on Body Composition and Weight Loss in African-American Adults. Obesity Res 13:1218-1225.
Zemel, MB. (2005)The Role of Dairy Foods in Weight Management. J Am Coll Nutr
Melanson, E.L., Donahoo, W.T., Dong, F., Ida, T., and Zemel, M.B. (2005) Effect of
low- and high-calcium dairy based diets on macronutrient oxidation in humans. Obesity Research 13:2102-2112.
Sun X.C. and Zemel M.B. (2006) Dietary calcium regulates ROS production in aP2-
agouti transgenic mice on high fat/high sucrose diets. Int J Obesity 30:1341-1346.
Sun, X.C. and Zemel, M.B. (2007) Calcium and 1,25-(OH)2-D3 regulation of adipokine
expression in murine and human adipocytes and aP2-agouti transgenic mice. Obesity 15:340-348.
Zemel, M.B. and Sun, X.C. (2007) Leucine and calcium regulate fat metabolism and
energy partitioning in murine adipocytes and muscle cells. Lipids 42:297-305.
Ding, S., McEntee, M.F., Whelan, J. and Zemel, M.B. (2007) Adiposity-Related
Protection of Intestinal Tumorigenesis: Interaction with Dietary Calcium. Nutrition and Cancer 58(2):153-161.
Sun X and Zemel MB (2007) 1α, 25-dihydroxyvitamin D3 modulation of reactive oxygen
species production and cell proliferation in human and murine adipocytes. Obesity15:1944-1953
Sun X. and Zemel M.B. (2007) Calcitriol and calcium regulate cytokine production and
adipocyte-macrophage cross-talk. J Nutr Biochem (in press).
Teegarden, D., White, K., Lyle, R.M., Zemel, M.B., Van Loan, M., Matkovic, V., Craig,
B. and Schoeller, D. (2007) Calcium and Dairy Product Modulation of Lipid Utilization and Energy Expenditure. Obesity (in press).
Sun X., Morris .KL. and Zemel M.B. (2008) Role of calcitriol and cortisol on human
adipocyte proliferation and oxidative and inflammatory stress: A microarray study. J Nutrigenetics and Nutrigenomics 1:30-48.
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EFFECT OF FERMENTED CHUB MACKEREL EXTRACT ON LIPID METABOLISM OF DIABETIC RATS U. Santoso1, S. Ishikawa2 and K. Tanaka2 1 Faculty of Agriculture, Bengkulu University, Bengkulu - Indonesia. 2Division of Bioresources and Bioproduction, Graduate School of Agriculture, Hokkaido University, Sapporo 060-0809 - Japan Corresponding E-mail: firstname.lastname@example.org Received January 26, 2