Microsoft word - michael zemel.doc

Michael Zemel
Professor of Nutrition and Medicine
Director, The Nutrition Institute
The University of Tennessee
1215 W. Cumberland Avenue – Room 229
Knoxville, TN 37996-1920
865-974-6238
mzemel@utk.edu
 
 
 
 
Education and Experience:
B.S. (Nutritional Sciences), University of Wisconsin, Madison, 1976; M.S. (Nutritional
Sciences), University of Wisconsin, Madison, 1978; Ph.D. (Nutritional Sciences/Physiology),
University of Wisconsin, Madison, 1980. Professor of Nutrition, University of Tennessee, 1990-
present; Professor of Medicine, University of Tennessee 1990-present; Head, Department of
Nutrition, University of Tennessee, 1990-2002; Director, The University of Tennessee Nutrition
Institute, 1994-present; Research Biochemist/Endocrinologist, VA Medical Center, Allen Park,
MI 1987-1991; Associate Professor of Endocrinology, Wayne State University, Detroit, MI,
1985-1990; Assistant/Associate Professor of Nutrition and Food Science, Wayne State
University, Detroit, MI, 1980-1990.
Research Area
Obesity and metabolic syndrome; regulation of adipocyte metabolism and of adipocyte-
muscle cross-talk.
Description of Research
Dr. Zemel’s laboratory focuses on endocrine and nutritional modulation of mitochondrial
function, energy metabolism and oxidative and inflammatory stress. This work encompasses
cellular and molecular approaches to the study of adipocyte, skeletal muscle cell and macrophage
metabolism and interactions, animal modelling of predicted outcomes from cellular studies, and
clinical studies in obesity and the metabolic syndrome to evaluate efficacy of approaches
developed in our laboratory.
Current and Recent Funding
Center for Disease Control
2004-2006
Principal Investigator: M.B. Zemel Obesity Prevention National Dairy Council
2000 - 2001
Principal Investigator: M.B. Zemel The Effects of Calcium–Rich Dairy Products on Weight Loss in Obese Adults 2000 – 2003 Effects of Calcium-Rich Dairy Products on Body Composition and Weight Loss in African-American Adults 2001 - 2002 Principal Investigator: M.B. Zemel Interaction Between Calcium-Rich Dairy Products and Dietary Macronutrients in Modulating Weight Loss in aP2-Agouti Transgenic Mice 2002 Role of Whey Proteins in Enhancing the Anti-Obesity Effects of Dietary Calcium Principal Investigator: M.B. Zemel 2002-2003 Principal Investigators: J.O. Hill and M.B. Zemel Role of Dairy Products in Promoting Fat Oxidation in Humans 2002-2004 Principal Investigator: M.B. Zemel; Co-PI’s: D. Teegarden, M. Van Loan and V. Matkovic Role of Dairy Products in Weight Loss: A Multi-Center Trial 2003-2004 $239,635 Principal Investigator: M.B. Zemel Role of Dairy Products in Weight Maintenance 2005-2006 Principal Investigator: M.B. Zemel Role of Dairy Products in Weight Maintenance II (Extended Studies) 2004-2005 Principal Investigator: M.B. Zemel Role of dairy components in enhancing the anti-obesity effects of dietary calcium 2006-2007 Principal Investigator: M.B. Zemel Dietary calcium and dairy modulation of oxidative and inflammatory stress in mice 2007-2008 Principal Investigator: M.B. Zemel Dairy modulation of oxidative and inflammatory stress in overweight and obese subjects 2003-open Principal Investigator: M.B. Zemel
Dairy-Obesity Research (annual recurring unrestricted grant)

2008-2009
Principal Investigator: M.B. Zemel
Dairy Attenuation of Oxidative and Inflammatory Stress in Metabolic Syndrome
Bell Institute for Human Nutrition

2000 - 2001
Principal Investigator: M.B. Zemel Role of Glycemic Index in a Rodent Model of Obesity and Diabetes 2000 - 2002 Principal Investigator: M.B. Zemel Effects of Fermented Dairy Products on Body Composition and Weight Control in Transgenic Mice. 2000 – 2001 Principal Investigator: M.B. Zemel Effects of Calcium-Fortified Breakfast Cereal on Body Composition and Weight Control in a Transgenic Model of Human Obesity 2002-2003 Principal Investigator: M.B. Zemel Effects of Calcium-Fortified Breakfast Cereal on Body Composition and Weight Control in Obese Adults 2002-2003 Principal Investigator: M.B. Zemel Effects of Fermented Dairy Products on Body Composition and Weight Control in Obese Adults 2003-open Principal Investigator: M.B. Zemel
Calcium-Obesity research (annual recurring unrestricted grant)
American Institute for Cancer Research
2002 – 2004
Principal Investigators: J. Whelan, M. McEntee and M.B. Zemel Prostaglandin E Receptors and Intracellular Calcium Signaling in Intestinal Tumorigenesis Mead Johnson & Company
2005
Principal Investigator: M.B. Zemel
Effects of Diet on Metabolism and Gene Expression
Takanashi, Inc.
2007-2008
Principal Investigator: M.B. Zemel Effects of Milk Fermentation on the Anti-Obesity Effect of Dairy PATENTS "Calcium Fortification": Patents issued 1990 in U.S., Canada, Taiwan, Spain and several other nations. (Patent issued 6/90) US 4906,482. “Modulation of the Sulfonylurea Receptor and Calcium in Adipocytes for Treatment of Obesity/Diabetes”. (Patent issued 8/00) US 6100047. “Screening for SUR1 Antagonists Using Adipocytes” (Patent issued 6/01) US 6242200.
“Materials and Methods for the Treatment and Prevention of Obesity” (Patent issued 5/02)
US 6384087.
“Modulation of the sulfonylurea receptor and calcium in adipocytes for treatment of
obesity/diabetes” (Patent issued 12/02) US 06492130
Zemel, et al, US Patent No. 6,384,087, issued May 7, 2002; Additional US patents for whey
approved 2007, issuance pending
China: Patent No. ZL01818078.7, issued May 2007
Australia, Patent No. 2001288707, issued April 2007
International: Patent Pending in Canada, European Union, Mexico, and New Zealand
(PCT/US01/27432)
Korea and Japan – Patent Pending (PCT/US02/40091)

Selected Recent Publications:
ƒ Shi H, Norman AW, Okamura A, and Zemel MB (2002) 1α,25-dihydroxyvitamin D3
inhibits uncoupling protein 2 expression in human adipocytes. FASEB J 16:1808-1810. ƒ Zemel M.B. (2003) Mechanisms of dairy modulation of adiposity. J Nutr 133:252S-256S. ƒ Zemel, MB, Thompson, W, Milstead, A, Morris, K, Campbell, P (2004) Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obesity Research 12:582-590. ƒ Zemel, MB (2004) Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr 79:907s-912s. ƒ Sun, X, Zemel, MB. Role of uncoupling protein 2 (UCP2) expression and 1α,25- Dihydroxyvitamin D3 in modulating adipocyte apoptosis. FASEB J 2004; 18:130-1432 (Expanded on-line version: http://www.fasebj.org/cgi/doi/10.1096/fj.04-1971fje) ƒ Sun, X, Zemel, MB (2004) Calcium and Dairy Inhibit Weight and Fat Regain During Ad Libitum Consumption Following Energy Restriction in Ap2-Agouti Transgenic Mice. J Nutr 134:3054-3060. ƒ Morris, KL, Zemel, MB. (2005) 1,25-dihyroxyvitamin D3 Modulation of adipocyte glucocorticoid function. Obesity Res; 13:670-677. ƒ Zemel, MB, Richards J, Mathis S, et al. (2005) Augmentation of total and central fat loss in obese subjects. Int J Obesity; 29:391-397. ƒ Zemel, MB, Richards, J., Milstead, A. and Campbell, P. (2005) Effects of Calcium and Dairy on Body Composition and Weight Loss in African-American Adults. Obesity Res 13:1218-1225. ƒ Zemel, MB. (2005)The Role of Dairy Foods in Weight Management. J Am Coll Nutr ƒ Melanson, E.L., Donahoo, W.T., Dong, F., Ida, T., and Zemel, M.B. (2005) Effect of low- and high-calcium dairy based diets on macronutrient oxidation in humans. Obesity Research 13:2102-2112. ƒ Sun X.C. and Zemel M.B. (2006) Dietary calcium regulates ROS production in aP2- agouti transgenic mice on high fat/high sucrose diets. Int J Obesity 30:1341-1346. ƒ Sun, X.C. and Zemel, M.B. (2007) Calcium and 1,25-(OH)2-D3 regulation of adipokine expression in murine and human adipocytes and aP2-agouti transgenic mice. Obesity 15:340-348. ƒ Zemel, M.B. and Sun, X.C. (2007) Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids 42:297-305. ƒ Ding, S., McEntee, M.F., Whelan, J. and Zemel, M.B. (2007) Adiposity-Related Protection of Intestinal Tumorigenesis: Interaction with Dietary Calcium. Nutrition and Cancer 58(2):153-161. ƒ Sun X and Zemel MB (2007) 1α, 25-dihydroxyvitamin D3 modulation of reactive oxygen species production and cell proliferation in human and murine adipocytes. Obesity15:1944-1953 ƒ Sun X. and Zemel M.B. (2007) Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk. J Nutr Biochem (in press). ƒ Teegarden, D., White, K., Lyle, R.M., Zemel, M.B., Van Loan, M., Matkovic, V., Craig, B. and Schoeller, D. (2007) Calcium and Dairy Product Modulation of Lipid Utilization and Energy Expenditure. Obesity (in press). ƒ Sun X., Morris .KL. and Zemel M.B. (2008) Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: A microarray study. J Nutrigenetics and Nutrigenomics 1:30-48.

Source: http://obesity.tennessee.edu/pdf/Faculty/MichaelZemel-Bio.pdf