New pharmacy cialis australia online viagradirect.net with a lot of generic and brand medicament with mean price and fast delivery.
April 23, 2007
P.O. Box 0991 Madisonville, LA 70447 Tel: (985) 845-4548 Fax: (985) 845-9913
Subject: Pharmacotherapy of ------------
I have conducted a pharmacotherapy review of the medication utilization pattern of --------. A full review
with evidence-based recommendations for therapeutic modifications is attached. A summary of key
recommendations are listed below. SUMMARY OF KEY RECOMMENDATIONS
The patient has not been treated for her original injury since 4/23/2007. However, the patient recently received prescriptions for Lyrica®, Lidoderm®, Ibuprofen and Skelaxin® after almost a year without any medication for her pain.
Lyrica® 75 mg
The clinical value of Lyrica®
Evidence-based reviews have suggested that
Lyrica® and gabapentin are equally effective and
safe. However, meta-analysis data comparing NNH
data from clinical trials does suggest that gabapentin
may actually be better tolerated (NNH for
gabapentin of 26.1 for versus 7.4 to 11.7 for
pregabalin). The patient’s current dose (150
mg/day) has been shown to be no more effective
than placebo in multiple clinical trials.
effectiveness at the 150 mg per day dose.
Skelaxin® acts as a systemic CNS depressant and
does not reduce muscle spasticity. The only agents
that have actually been shown to reduce muscle
spasticity chronically are baclofen, tizanidine and
dantrolene. An alternative therapy to Skelaxin®
would be tizanidine (as baclofen may cause muscle
even superior, therapeutic results for $800 less per year.
An evidence-based review of Lidoderm® (in Pain
has suggested that it may be considered as a first-
line agent (on par with gabapentin, nortriptyline,
etc), yet they also suggest that… “Because of its
medication (e.g., lidocaine jelly, safety and ease of use, lidocaine gel can be dibucaine ont). Switching the
considered when the lidocaine patch 5% is not
available, application of a patch is problematic, or
the cost of the lidocaine patch 5% precludes its use.”
Multiple generic alternatives could provide similar
therapeutic results at a significantly reduced cost.
Thank you for your time and consideration,
MEDICATION REVIEW (DUR)
Patient Name: ------------
1) Neck/Arm Injury from Flipping Mattress
Rx Cost Per
Year (12 Rx/Yr)
SUMMARY OF RECOMMENDATIONS:
Supporting Clinical Evidence
results (see data below). Therapy is only recommended for
CLINICAL AND ECONOMIC EVIDENCE FOR CHANGE
The patient has not been treated for her original injury since 4/23/2007. However, she recently received
prescriptions for Lyrica®, Lidoderm®, Ibuprofen and Skelaxin® after almost a year without any medication
for her pain. The origination of this pain flare and any relationship to the original injury (versus some other
injury that has occurred in recent months) should be considered. If therapy is deemed related to the original
injury, then please consider the following review of her medications. Lyrica®, Lidoderm® and Skelaxin® all
have equally effective, and in some cases safer and more effective, alternatives that are significantly less
expensive. As she has not been stabilized on these drugs for months or years, conversions would likely be
less problematic. Lyrica® (pregabalin)
Lyrica® (pregabalin) is a structural congener of gabapentin or a "second-generation gabapentin".1-4
Pregabalin and gabapentin display similar pharmacology, mechanisms of action and therapeutic effects. In
clinical trials involving diabetic peripheral neuropathy, 300 mg of pregabalin daily was associated with only
modest improvements in pain scores (e.g., 1.7 point placebo adjusted reduction in pain score at 8 weeks);
however, 150 mg per day was found to be no more effective than placebo
(patient’s current dose).5,6 The
150 mg and 300 mg per day doses were found to be no more effective than placebo in a trial involving
patients with fibromyalgia.7 In one trial involving post-herpetic neuralgia, the 150 mg/day dose was found to
be minimally effective (0.88 point placebo adjusted reduction in pain).8 Therefore, based on current clinical
trial data, the effectiveness of Lyrica® 75 mg twice daily is questionable. This could represent a very
expensive “placebo” at a cost of $1,452 per year.
In general, the value of Lyrica® relative to generic gabapentin should be questioned. An evidence based
review on the treatment of neuropathic pain was very recently published in Pain
.9 This review suggested that
either gabapentin or Lyrica® may be considered for first-line status. The review stated “the potential for
twice daily dosing and the linear pharmacokinetics of Lyrica® may contribute to relatively greater ease of use
compared with gabapentin, but the overall efficacy and tolerability of these two medications appear similar”.
The linear pharmacokinetics may allow for more rapid onset of action when first titrating a patient; however,
this difference is minimal (e.g., several weeks) and will not represent an advantage once patients are titrated
to effective doses.
Two other evidence based reviews have concluded that the number-needed-to-treat (NNT) and number-
needed-to-harm (NNH) for gabapentin and pregabalin were similar, if not favorable towards gabapentin.10-11
The NNT for gabapentin was 3.8 versus 3.7 to 4.2 for pregabalin. However, NNH was 26.1 for gabapentin
versus 7.4 to 11.7 for pregabalin.
Overall, it appears that Lyrica® and gabapentin are basically equivalent. However, Lyrica® costs about
$1,200 more per year in this patient. Therefore, please consider switching the patient to generic gabapentin or
simply discontinuing Lyrica® therapy due to questionable effectiveness at the 150 mg per day dose. Skelaxin® (metaxalone)
Skelaxin® acts as a systemic CNS depressant and does not reduce muscle spasticity per se.1,12-13 Clinical trial
data supporting the safety and efficacy of Skelaxin® in patients with acute muscle spasms dates back to the
mid-1960s.12-13 Assumptions regarding the efficacy and safety of Skelaxin® based on these trials may not be
accurate considering the many study limitations.12-13 These trials were of short-duration (i.e., <10 days),
poorly controlled, patient selection was not clearly defined, methods for determining the presence of muscle
spasms was not established, objective parameters were not used, and concomitant medication and physical
therapy were either allowed or not addressed in these studies.12-13 Clinical trial data, package insert
recommendations and expert opinions all suggest that Skelaxin® should only be employed as an adjunctive
therapy for acute conditions (e.g., < 14 days of therapy).1,12-13 Therefore, consideration should be given to
limiting Skelaxin® therapy to a short-term duration (only 1 prescription).
The only skeletal muscle relaxants that have actually been shown to reduce muscle spasticity chronically are
baclofen, tizanidine and dantrolene.13 An excellent alternative therapy to Skelaxin® for muscle spasticity
would be tizanidine (as baclofen is more prone to cause muscle weakness). Switching the patient to more
effective generic tizanidine would save more than $800 per year.
Recommendations for Skelaxin®
1) Consider limiting Skelaxin® therapy to a short-term treatment (i.e., only 1 prescription).
2) If a long-term treatment is desired, consider switching to generic tizanidine as it would provide
equivalent, or possibly even superior, therapeutic results at a cost of $800 less per year.
3) If tizanidine is not considered, other generic alternatives include low-dose cyclobenzaprine and
orphenadrine; however, like Skelaxin®, these agents have not been shown to reduce muscle spasticity on a chronic basis.
Lidoderm® (lidocaine jelly)
Although Lidoderm® has been shown to be effective for short-term use (generally used for 2 to 4 weeks in
clinical trials) in patients with postherpetic neuralgia, it has not been shown to be effective for long-term
administration in treating other neuralgias.14 The evidence-based review of neuropathic pain does suggest
that Lidoderm® may be considered as a potential first-line treatment option on par with generic gabapentin.9
However, it also states that…
“Because of its safety and ease of use, lidocaine gel can be considered when the lidocaine patch 5% is not available, application of a patch is problematic, or the cost of the lidocaine patch 5% precludes its use.”
If 12 prescriptions of Lidoderm® are filled every year the cost would exceed $2,700 at the current frequency
of administration and as much as $8,000 if maximum doses are used. Therefore, the value of Lidoderm®
relative to alternative oral medications (e.g., gabapentin, nortriptyline) and topical medications (e.g., lidocaine
jelly, dibucaine ont) is questionable. Switching the patient to one of these alternatives would save between
$2,000 and $2,500 per year at the patient’s current Lidoderm® dose. The only disadvantage for the topical
lidocaine and dibucaine products is that they have to be reapplied two to three times daily. Neuropathic Pain Considerations
Although Lyrica® and Lidoderm® are both effective and considered potential first-line treatments in the
management of neuropathic pain, equally effective and lower cost alternatives should be considered. Many of
these alternatives have already been stated in this review; however, the alternatives with their approximately
monthly cost include the following:
• Lidocaine jelly, lotion, cream or ointment – cost varies, but ranges from $5-$50 per month
These agents are highly effective, have decades of evidence supporting their use and are very inexpensive. Please consider a trial on one or more agents.
1. Facts and Comparisons. Wolters Kluwer Health, Inc. 2007.
2. Guay DR. Pregabalin in neuropathic pain: a more "pharmaceutically elegant" gabapentin? Am J Geriatr
3. Bialer M. New antiepileptic drugs that are second generation to existing antiepileptic drugs. Expert Opin
4. Zareba G. Pregabalin: a new agent for the treatment of neuropathic pain. Drugs Today (Barc).
5. Rosenstock J, Tuchman M, LaMoreaux L, Sharma U. Pregabalin for the treatment of painful diabetic
peripheral neuropathy: a double-blind, placebo-controlled trial. Pain
6. Richter RW, Portenoy R, Sharma U, Lamoreaux L, Bockbrader H, Knapp LE. Relief of painful diabetic
peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J Pain
7. Crofford LJ, Rowbotham MC, Mease PJ, et al. Pregabalin for the treatment of fibromyalgia syndrome:
results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2005;52(4):1264-73.
8. van Seventer R, Feister HA, Young JP Jr, Stoker M, Versavel M, Rigaudy L. Efficacy and tolerability of
twice-daily pregabalin for treating pain and related sleep interference in postherpetic neuralgia: a 13-week, randomized trial. Curr Med Res Opin. 2006;22(2):375-84.
9. Dworkin RH, O’Connor AB, Backonja M, et al. Pharmacologic management of neuropathic pain:
evidence-based recommendations. Pain. 2007;237-51.
10. Finnerup NB, et al. Algorithm for neuropathic pain treatment: An evidence based proposal. Pain
11. Finnerup NB, Otto M, Jensen TS, Sindrup SH. An evidence-based algorithm for the treatment of
neuropathic pain. MedGenMed. 2007;9(2):36.
12. Toth PP, Urtis J. Commonly used muscle relaxant therapies for acute low back pain: a review of
carisoprodol, cyclobenzaprine and metaxalone. Clin Therap
13. Chou R, Peterson K, Helfand M. Comparative efficacy and safety of skeletal muscle relaxants for
spasticity and muscloskeletal conditions. Jour Pain Symp Mgmt
14. Davies PS, et al. Review of lidocaine patch 5% studies in the treatment of postherpetic neuralgia. Drug
Physician Response Form
DUR – ---------------
Dear treating physician, After reviewing the DUR on ------------------, please fill-in and sign the response form below:
Logic Supporting Rejection
Recommendation(s) from DUR
If chronic therapy is required, consider
If chronic therapy is required, consider
Additional Documentation (if required):
Physician Signature: Date:
ACLEARA PRE-TREATMENT INSTRUCTIONS Minimize sun exposure, use of self-tanning products, sunless tanning beds and spray tans before treatment. If you have a history of recurrent cold sores/Herpes 1 or 2, please pre-treat with an anti-viral medication. If you need one, Dr. Espinoza will prescribe Valtrex 1mg for this treatment, please call 215-862-6100 WAXING PRE-TREATMENT INSTRUCTIONS ●
(Incorporated in the Cayman Islands with limited liability) (the “Company”) (Stock Code: 3999) LETTER TO EXISTING REGISTERED SHAREHOLDERS – ELECTION OF LANGUAGE OF FUTURE CORPORATE COMMUNICATIONS We are pleased to enclose the 2008 Annual Report and the circular dated 22 April 2009 (the “Circular”) of the Company for your attention. The 2008 Annual Report and the Circular hav