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Http://www.lef.org/newsletter/2004/2004_11_11.htm

Life Extension Newsletter, November 11, 2004 In this issue
Life Extension Update Exclusive:
Adding psyllium to simvastatin as effective as doubling dose Protocol:
Featured Products:
Life Extension magazine November 2004 issue:
Novel Dietary Supplement Shows Dramatic Effects in Lowering Cholesterol, LDL, and Risk free: You may
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Life Extension Update Exclusive
Adding psyllium to simvastatin as effective as doubling dose
Research presented on November 9 2004 at the American Heart Association's scientific sessi name@domain.com
when psyllium, a widely available fiber supplement, was added to 10 milligrams simvastatin, theffects were as effective at lowering low density lipoprotein (LDL) cholesterol as doubling the dStatin drugs are effective in lowering LDL cholesterol, thereby reducing the risk of cardiovascuthe drugs have side effects that preclude many individuals from taking optimal doses. Researchers at Robert Wood Johnson Medical School in New Jersey randomized 67 patientsLDL to receive 20 milligrams simvastatin plus a placebo, 10 milligrams simvastatin plus a placmilligrams simvastatin plus psyllium for eight weeks. Treatment was preceded by a four week period. At the conclusion of the treatment regimen, the group who received psyllium experiencgreater reduction in LDL cholesterol than those who received 10 milligrams simvastatin alone,comparable to the benefit provided by 20 milligrams simvastatin. Lead author and professor of medicine at University of Medicine and Dentistry New Jersey RoJohnson Medical School, Abel E. Moreyra, MD, stated, "The results of this study present a bretreatment of high cholesterol, providing patients with a viable option to taking high-dosage stacholesterol. This is an important new perspective because while statins are a safe and effectivcholesterol, there are risks associated with a higher dosage treatment." Chairman of the National Fiber Council and professor of the Metabolic Research Group at theKentucky James Anderson, MD, commented, "This new research further validates what doctoresearchers have been saying for decades -- fiber plays a critical factor in a nutritionally balanmillions of Americans falling short of the recommended 32 grams of fiber per day, these findinmore critical for physicians to educate all consumers about how fiber works in the digestive sycontributes to overall health." http://www.lef.org/newsletter/2004/2004_11_11.htm Life Extension Newsletter, November 11, 2004 Protocol
Cholesterol Reduction
High intake of soluble fiber is a very effective way of lowering serum cholesterol. Most people,
that high amounts of fiber produce gastrointestinal upset, and therefore do not consistently tak
lower cholesterol levels.
Chitosan is a fiber composed of chitin, which is a component of the shell of shellfish. Scientistprocessed chitin to provide a magnetic binding affinity for fat and cholesterol in the digestive trabsorb as much as seven to eight times its weight of fat and bile in the digestive tract. The fat are then excreted through the bowel, thereby improving bowel function and reducing cholestebody. One of the first studies to show a direct correlation between lowering of serum cholesterol withsuggesting that the agent could be used to inhibit the development of atherosclerosis in individhypercholesterolemia-appeared in the June 1998 issue of Atherosclerosis Journal. ResearcheDepartment of Medicine, University of Auckland, New Zealand, found that animals fed for 20 wcontaining 5% chitosan or on a control diet attained blood cholesterol levels significantly lowerfed animals throughout the study and at 20 weeks were 64% below that of control animals. Additionally, when the area of aortic plaque in the two groups of animals were compared, a higinhibition of plaque deposits was observed in the chitosan-fed animals-42% and 50%, comparcontrol animals. Earlier in the August-October 1994 issue of the journal ARM Medicina, Helsinwith chitosan demonstrated that in 5 weeks total cholesterol (LDL) was reduced by 32%, HDL7.5%, and triglycerides were lowered by 18%. Another study done almost 20 years ago in the April 1980 American Journal of Clinical Nutritio30% reduction in cholesterol over a several-month period, initially documenting chitosan's potlowering effectiveness. Because of chitosan's ability to bind fat, chitosan is also an excellent aid in weight loss as welof cholesterol levels in the body. http://www.lef.org/protocols/prtcl-032.shtml Featured Products
Chitosan
Chitosan is a fiber composed of chitin, which is a component of the shell of shellfish. Scientists have processed chitin so that it has a high binding (absorption) affinity for fat and cholesterol in the digestive tract. Fibers such as chitosan can absorb many times their weight of fat and cholesterol. Since cholesterol is normally secreted with the bile and reabsorbed in the intestine, fibers like chitosan can help remove cholesterol from inside of the body. The absorbed fat and cholesterol are excreted through the bowel, improving bowel function. Ascorbic acid (vitamin C) helps activate chitosan in the stomach and intestine into a fat-absorbing gel. http://www.lef.org/newshop/items/item00216.html Fiber Food capsules
http://www.lef.org/newsletter/2004/2004_11_11.htm Life Extension Newsletter, November 11, 2004 Fiber Food provides natural, bulk-producing soluble fiber. These fibers help maintain healthy bowel function and help to maintain cholesterol levels that are already within the normal range. Fiber Food helps clean the walls of the intestines and enhances the elimination of fecal mutagens. http://www.lef.org/newshop/items/item00229.html Life Extension magazine November 2004 issue
Novel Dietary Supplement Shows Dramatic Effects in Lowering Cholesterol, LDL, and T
Jim English

A newly available, all-natural supplement has been shown in human studies to significantly lowlevels—particularly of LDL, triglycerides, and apolipoprotein B—thus helping to reduce the riskcardiovascular disease. This supplement, called Sytrinol™, is an important option for health-cseeking a safe, effective, and convenient way to lower cholesterol levels without the side effecdrugs. http://www.lef.org/magazine/mag2004/nov2004_report_sytrinol_01.htm Questions? Comments? Send them to ddye@lifeextension.com or call 954 766 8433 extensio Dayna Dye Editor, Life Extension Update ddye@lifeextension.com LifeExtension.com 1100 West Commercial Boulevard Fort Lauderdale FL 33309 954 766 8433 extension 7716 Sign up for Life Extension Update at http://mycart.lef.org/subscribe.asp Help spread the good news about living longer and healthier. Forward this email to a friend! View previous issues of Life Extension Update in the Newsletter Archive. Home | Membership | Products | Magazine | Health Concerns | News About Us | Legal Notices | Privacy Policy | Site Map All Contents Copyright 1995-2005 Life Extension Foundation All rights reserved. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician oprofessional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnany health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before startor supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stomedication without first consulting your physician. http://www.lef.org/newsletter/2004/2004_11_11.htm

Source: http://www.nationalfibercouncil.org/pdfs/lef.org.pdf

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Agenda Advancing economics in business Shades of grey: arguments for and against parallel trade in pharmaceuticals Last month the European Court of Justice announced its judgment on Syfait v GlaxoSmithKline, the latest case concerning parallel trading (aka grey imports). One of the most pressing competition issues facing the pharmaceutical industry, this topic was discussed during the seco

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