MEDISCA INC.
661 Route 3, Unit C, Plattsburgh, New York, 12901 Tel.: (800) 665-6334 Fax: (518) 563-5047
Material Safety Data Sheet I - Product Identification: Code: Product Name: Tretinoin, USP (Retinoic Acid) CAS#: 302-79-4 Empirical Formula: Chemical Name: Uses:
Keratolytic; all trans-form also as antineoplastic.
II - Toxicological Information:
Irritancy: Adverse Effects: Toxicity Data: III - Physical Data: Physical State: Description:
Yellow to light orange, crystalline powder.
Solubility:
Insoluble in water; slightly soluble in alcohol, and in chloroform.
Other Physical Properties: USP Specifications:
Identification<197M><197U>: Conforms to the std tests (A,B) Loss on drying<731>:
Residue on ignition<281>: <= 0.1%
Preserve in tight containers, preferably under an atmosphere of an inert gas, protected from light.
IV - Fire And Explosion Hazards: Flammability: Flash Point: Extinguishing Media:
Water spray, carbon dioxide, dry chemical, or chemical foam.
Fire-Fighting:
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.V - Reactivity Data:
Preventive Measures:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical hood.
Personal Protective Equipment:
Chemical resistant gloves, chemical goggles, protective clothing. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN149 approved respirator when necessary.
Specific Engineering Controls:
Eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Spill & Leaks:
Vacuum or sweep up material and place into a suitable disposal container.
Waste Disposal:
Dispose of in a manner consistent with federal, state, and local regulations.
Storage:
Preserve in tight containers, preferably under an atmosphere of an inert gas,
VII - First Aid Measures: Eyes:
Flush with copious amounts of water for 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Wash with plenty of soap & water for 15 minutes while removing contaminated clothing and shoes. Get medical aid.
Ingestion:
Get medical aid. Wash out mouth with water.
TRETINOIN, USP (RETINOIC ACID) JULY 2007 MEDISCA INC.
661 Route 3, Unit C, Plattsburgh, New York, 12901 Tel.: (800) 665-6334 Fax: (518) 563-5047
Inhalation:
Remove to fresh air. If not breathing, give A.R. If breathing is difficult, give oxygen. Get medical aid.
NOTE: If victim is unconscious, never induce vomiting nor give liquids. Place victim in a stable side position and keep warm. Ecological Data: Hazardous Ingredients: References: TRETINOIN, USP (RETINOIC ACID) JULY 2007
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