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Effect of Oral Sucralfate on Side Effects of External Radiation Therapy in
Patients with Head and Neck Cancer
Early side effects of irradiation for head and neck cancers are very common and
disturbing. These events may cause a transient disruption in the treatment course. The aim of
this study was to evaluate the role of sucralfate on radiation side effects. Patients and
Between November 1999 and January 2002, eighty patients with head and neck
cancers who were referred to the Radiotherapy Department of Nemazee Hospital were divided into two groups. Group I was
treated with external radiotherapy alone and group II received
irradiation and oral sucralfate. The total dose of radiation was at
least 50 Gy and sucralfate was started at the beginning of
irradiation and was continued for 9 weeks at an oral dose of 1
gram, three times a day. The patients were evaluated weekly and
the side effects were scored. Results:
The intensity of radiation
side effects (subjective tolerance, dysphagia, dermatitis and
mucositis and also treatment time interruption) did not differ
significantly between the two groups (p>0.05). However,
Shiraz University of Medical Sciences,
sucralfate significantly induced more nausea and vomiting in
Group II as compared to Group I (p<0.05). Conclusion:
According to this study, using sucralfate in order to decrease radiation-induced side effects in head and neck cancers not only is ineffective in reducing radiation mucositis and other side effects but also induces nausea and vomiting.
Cancer, Head and neck, Radiotherapy, Sucralfate,
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sucralfate reduce the acute side-effects in head and neck cancer
treated with radiotherapy? A double blind randomized trial.
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mucosa? Histologic, ultrastructural and functional assessment in the rat. Gastroenterology
Epstein JB, Wong FLW: The efficacy of sucralfate suspension in the prevention of oral
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following radiotherapy of malignancies in the head and neck region : A double blind placebo
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of inflammation of the mucosa by sucralfate treatment. HNO
Antiviral guidance for suspected, probable, or confirmed novel H1N1 influenza The Centers for Disease Control and Prevention would like to emphasize that it is very important to get the word out to clinicians, particularly those in primary care (including internists, pediatricians, family practitioners, OB-GYN physicians) and hospital-based clinicians (emergency physicians, hospitalists, int
The Institute for Safe Medication Practices Canada (ISMP Canada) is an analysis of medication error reports and ISMP Canada Safety Bulletin ALERT: Revatio (sildenafil) Medication Incident It is well-known to healthcare practitioners that use of nitroglycerin therapy is contraindicated in patients taking The urgency of the situation (i.e., patient with sildenafil (commonly known as