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Is a once-daily human GLP-1 (Glucagon-Like Peptide-1) analogue
approved for the treatment of type 2 diabetes in adults.1
Has 97% similar to the body’s own hormone (GLP-1). GLP-1 is a natural
hormone in the body that plays a critical role in maintaining a healthy
level of sugar in the blood. In type 2 diabetes, GLP-1 production and
Lowers blood sugar levels by stimulating the release of insulin from beta
cells and reducing the release of glucagon from alpha cells when blood
sugar levels are high and by slowing gastric emptying.1
o Insulin lowers blood sugar by increasing sugar uptake primarily in
o Glucagon increases blood sugar primarily by releasing sugar stores
Also, reduces body weight and body fat mass in people with type 2
diabetes through mechanisms involving reduced hunger and lowered
Is a once-daily injection given any time of day independent of meals.1
Was extensively tested in a clinical trial programme including more than
Novo Nordisk A/S
Has been directly compared, in terms of safety and efficacy, against
commonly-used diabetes treatments like glimepiride, rosiglitazone,
glargine, exenatide and sitagliptin in phase 3a and b clinical trials.3-9
Has been documented in clinical trials to:
o Improve the function of insulin-producing beta cells3-9
: Victoza® has been approved by different regulatory agencies as a once-
daily injection for the treatment of adults with type 2 diabetes mellitus to
achieve glycaemic control. Victoza® has received:
Approval by EMA (Europe) in combination with:
Metformin or a sulphonylurea in patients with insufficient glycaemic
control despite maximal tolerated dose of monotherapy with metformin
Metformin and a sulphonylurea or metformin and a thiazolidinedione in
patients with insufficient glycaemic control despite dual therapy.
as monotherapy or as an add-on to sulphonylurea (SU) in people with
Approval by US Food and Drug Administration:
As an adjunct to diet and exercise to improve glycaemic control in adults
with type 2 diabetes. This provides for Victoza® to be used in monotherapy, as second-line treatment and in combination with
commonly prescribed oral medications for diabetes.
Novo Nordisk A/S
1. Victoza® Summary of Product Characteristics (SPC) is available at novonordisk.com. Victoza
2. Højberg PV et al. Four weeks of near-normalisation of blood glucose improves the insulin
response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia 2009;52:199–207.
3. Marre M et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over
26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabetic
4. Nauck M et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in
combination with metformin in type 2 diabetes mellitus (LEAD-2 Met). Diabetes Care 2009;
5. Garber A et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3
Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009;
6. Zinman B et al. Efficacy and safety of the human GLP-1 analog liraglutide in combination with
metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care 2009; 32: 1224-1230.
7. Russell-Jones D et al. Liraglutide vs insulin glargine and placebo in combination with
metformin and sulphonylurea therapy in type 2 diabetes mellitus: a randomised controlled
trial (LEAD-5 met+SU). Diabetologia 2009; 52(10):2046-2055.
8. Buse J et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-
week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009; 374
9. Novo Nordisk Interim financial report for the period 1 January 2009 to 30 June 2009 (6
Novo Nordisk A/S
NAME: _______________________________________________________________ Appointment Date: ____________________________ Appointment Time: __________ If you are currently taking Beta Blockers or Nitrates, (see attached list), you will need to stop them 12 hours before the test time. This will help produce more accurate results. CONTINUE TAKING ALL YOUR OTHER MEDICATIONS AS YOU HAVE BEEN DOING.
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