CURRICULUM VITAE
(Abstracts and Talks Not Included) 3/1/09
NAME Darrell Vincent Lewis, Jr., M.D. PRIMARY ACADEMIC APPOINTMENT Department of Pediatrics SECONDARY ACADEMIC APPOINTMENT Department of Neurobiology PRESENT ACADEMIC APPOINTMENT Professor DATE AND RANK OF FIRST ACADEMIC APPOINTMENT Assistant Professor, July 1978 MEDICAL Minnesota (#19201), July 2, 1970 LICENSURE North Carolina (#20309), August 8, 1978 SPECIALTY CERTIFICATION American Board of Psychiatry and Neurology- Neurology with special competence in Child Neurology (#348), January 1980; American Board of Qualification in Electroencephalography,Inc., December 1974 DATE OF BIRTH February 3, 1943, Minnesota Citizenship: USA EDUCATION High School: Mankato, Minnesota, 1961, Diploma College:University of Minnesota, B.A. 1965
SOCIETIES Alpha Omega Alpha Medical Honor Society, James
University of Minnesota PROFESSIONAL July 1969-June 1971 Pediatric House Staff TRAINING & Member, Community and Harriet Lane ACADEMIC CAREER Services, Johns Hopkins Hospital, CONT. Baltimore, Maryland July
Disease and Stroke, United States Public Health Services. July 1971-June 1975 Volunteer Pediatric Coordinator, Anacostia Community Health Center, 1358 W. Street, S.E. Washington, D.C. July 1975-June 1976 Fellow, Department of Pediatrics, Division of Pediatric Neurology,
Center, Durham, NC July 1976-June 1978 Fellow, Department of
Baltimore, Maryland July 1978 - March 1986 Assistant Professor Division
University Medical Center, Durham, NC March 1986 - January 1998 Associate Professor Division of Pediatric Neurology,
Duke University Medical Center September
January 1983-June 1990 Medical director Electrophysiology Training Program, Duke University Medical Center July 1989 - June 1994 Assistant Professor Department of Neurobiology Duke University Medical Center August 1994 - Present Associate Professor Department of Neurobiology Duke University Medical Center April 1994 - 2002 Acting Chief Division of Pediatric Neurology Duke University Medical Center
PUBLICATIONS IN PEER REVIEWED JOURNALS: 1) Rogers W, Edlich RR, Lewis DV, Aust JB: Tumor blood flow: I: Blood flow in transplantable tumors during growth. Surg Clin N A, 47:1467, 1967. 2) Lewis DV, Staley NA, Rogers W, Edlich, RR: Studies on distribution of blood flow in amelanotic melanoma and reticulum cell lymphosarcoma during growth. Cancer Research 28:1507, 1968. 3) Christian ST, Gorodetsky CW, Lewis DV: Structure activity relationships of normeperidine congeners on cholinesterase systems
in vitro and analgesia in vivo. Biochem. Pharmacol. 20:1167, 1971. 4) O'Connor MJ, Lewis DV, Hermon CJ: Effects of potassium on oxidative metabolism and seizures. Electroenceph. Clin. Neurophysiol. 35:205, 1973. 5) Lewis DV, O'Connor MJ, Schuette WH: Oxidative metabolism during recurrent seizures in the penicillin treated hippocampus. Electroenceph. Clin. Neurophysiol. 36:347, 1974. 6) O'Connor, MJ, Lewis DV: Recurrent seizures induced by potassium in the penicillin treated hippocampus. Electroenceph. Clin. Neurophysiol. 36:337, 1974. 7) Schuette WH, Whitehouse WC, Lewis DV, O'Connor J, Van Buren J: A television fluorometer for monitoring oxidative metabolism in intacttissue. J. Assoc. Adv. Med. Inst. 8:331, 1974. 8) Schuette WH, Lewis DV, O'Connor M, VanBuren JM: The design and operation of a dual beam fluorometer for monnitoring oxidative metabolism in vivo. Medical and Biological Engineering 14:235, 1976. 9) Lewis DV, Schuette WH: NADH fluorescence and k+ changes during hippocampal electrical stimulation. J. Neurophysiol. 38:405, 1975. 10) Lewis DV, Schuette WH: Temperature dependence of potassium clearance in the central nervous system. Brain Research 99:175, 1976. 11) Lewis DV, Schuette WH: NADH flourescence, K+ and oxygen consumption in cat cerebral cortex during direct cortical stimulation. Brain Research 110:523, 1978. 12) Mutsuga N. Schuette WH, Lewis DV: The contribution of local blood flow to the rapid clearance of potassium from the cortical extracellular space. Brain research 116:431,1976. 13) Lewis DV, Mutsuga N, Schuette WH, VanBuren JM: Potassium clearance and reactive gliosis in the alumina gel lesion. Epilepsia 18:499, 1977.
14) Lewis DV, Freeman JM: The Electroencephalogram in Pediatric Practice:its use and abuse. Pediatrics 60:324, 1977. 15) Van Buren JM, Lewis DV, Schuette W, Whitehouse WC, Ajmone- Marsan C: Fluorometric monitoring of NADH levels in cerebral cortex. Preliminary observations in human epilepsy. Neurosurgery 2:114, 1978. 16) Lewis DV: Diphenylhydantoin reduces the outward current of the actionpotential of Aplysia. Brain Research 207:234, 1981. 17) Lewis DV, Zbicz KL, Nepp ME, Colmers WF, Wilson WA: Diphenylhydantoin enhances early adaptation in Aplysia giant Neurons. J. Pharmacol. Exp. Ther. 218:41, 1981. 18) Dubois PJ, Freemark MJ, Lewis DV, Drayer BP, Heinz ER, Osborne D: Atypical findings in adrenoleukodystrophy. J. Comp. Assist. Tomo. 5:888, 1981. 19) Lewis DV, Wilson WA: Calcium influx and the post stimulus current during early adaptation in Aplysia giant neurons. J. Neurophysiol. 48:202, 1982. 20) Colmers WF, Lewis DV, Wilson WA: Cs+ loading reveals Na+ dependent persistent inward current and negative slope resistance region in Aplysia giant neurons. J. Neurophysiol. 48:1191, 1982. 21) Lewis DV, Spike aftercurrents in R15 of Aplysia: Their relationship to slow inward current and calcium influx. J. Neurophysiol. 51:403, 1984. 22) Lewis DV, Evans GB and Wilson WA: Dopamine reduces slow outward current and calcium influx in burst firing neuron R15 of Aplysia. J. Neurosci. 4: 30l4, 1984. 23) Brazy JE, Lewis DV, Mitnick MH, Jobsis-vander Vliet FF: Non- invasive monitoring of cerebral oxygenation in preterm infants. Preliminary observations. Pediatrics 75:217, 1985. 24) Huguenard, JR, Zbicz KL, Lewis DV, Evans GJ, Wilson WA. The ionic mechanism of the slow outward current in Aplysia neurons. J. Neurophysiol. 54:449, 1985. 25) Kaplan PW and Lewis DV. Juvenile acute intermittent
porphyria with hypercholesterolemia and epilepsy. J. of Child Neurol. 1:38, 1986. 26) Brazy JE and Lewis DV. Changes in cerebral blood volume and cytochrome AA3 during hypertensive peaks in preterm infants. J. Ped. 108:983, 1986. 27) Jones LS, Evans GJ, Wilson WA and Lewis DV. A novel triphasic current response in silent, non-bursting Aplysia neurons. Brain Research 385:46-50,1986. 28) Anderson WW, Lewis DV, Swartzwelder S and Wilson WA. Magnesium-free medium activates ictal-like events in the rat hippocampal slice. Brain Research 398:215-219, 1986. 29) Swartzwelder, HS, Lewis DV, Anderson WW and Wilson WA. Seizure-like events in brain slices: Suppression by Interictal activity. Brain Research 410:362-366, 1987. 30) Williams, LB, Thompson EA and Lewis DV. Intractable partial complex seizures: The initial motionless stare and surgical outcome following temporal lobectomy. Neurology, 37:1255-1258, 1987. 31) Lewis, DV. Calcium activated inward spike aftercurrents in bursting neuron R15 of Aplysia. J. Physiol. (London) 395:285- 302, 1987. 32) Jones, LS and Lewis DV. A Calcium-activated, nonselective cationic conductance in Aplysia silent neurons. Br. Res. Bull. 20:607-609, 1988. 33) Wilson, WA, Swartzwelder, HS, Anderson, WW, Lewis DV. Seizure Activity in Vitro: A dual focus model. Epilepsy Res. 2:289-293, 1988. 34) Mott, DD, Bragdon, AC, Lewis, DV and Wilson, WA. Baclofen has a pro-epileptic effect in the rat dentate gyrus. J. Pharmacol. Exp. Ther. 249:721-725, 1989. 35) Lewis, DV, Jones, LS, and Swartzwelder, HS. The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion. Epilepsy Res. 4:109-118, 1989.
36) Lewis, DV, Jones, LS and Mott, DD. Baclofen induces sponta- neous, rhythmic sharp waves in the rat hippocampal slice. Experimental Neurol. 106:181-186, 1989. 37) Walczak, TS, Radtke, RA, McNamara, JO, Lewis, DV, Thompson, E, Friedman, AH, Nashold, BS and Luther, JS. Anterior temporal lobectomy for complex partial seizures: Evaluation, results and long term followup in 100 cases. Neurology 40:413-418, 1990. 38) Lee, PHK, Xie, CW, Lewis, D, Wilson, W, Mitchel, CL and Hong, JS. Opioid induced epileptiform bursting in hippocampal slices: Higher susceptibility in ventral than in dorsal hippocampus. J. Pharmacol. Exp. Ther. 253:545-551, 1990. 39) Group for Evaluation of Cinromide in the Lennox-Gastaut Syndrome. Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut syndrome. Epilepsia. 30:422-429, 1989. 40) Lewis, DL, Jones, LS and Mott, DD: Hippocampal epileptiform activity induced by magnesium-free medium: Differences between areas CA1 and CA2-3. Epilepsy Res. 6:95-101, 1990. 41) Mott, DD, Bragdon, AC and Lewis, DV. Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus. Neurosci. Lett. 110:131-136, 1990. 42) Chung, MY, Walczak, TS, Lewis, DV and Radtke, R: Temporal lobectomy and independent bitemporal interictal activity: What degree of lateralization is sufficient? Epilepsia 32:195-201, 1990. 43) Mott, DD, Lewis, DV, Ferrari, C, Wilson, WW and Swartzwelder, HS. Baclofen facilitates the development of long term potentiation in the rat dentate gyrus. Neurosci. Letts. 113:222-226, 1990. 44) Jones, LS, Lapadula, DM, Lewis, DV. and Abou-Donia, MB. Effect of diisopropyl phosphorofluoridate (DFP) on CA3 and CA1 responses in rat hippocampus. J. Molec. Chem. Neuropath., 13:1-16, 1990. 45) Morrisett, RA, Mott, D.D., Lewis, DV, Wilson, WA, and Swartzwelder, HS. Reduced sensitivity of the N-methyl-D-aspartate
component of synaptic transmission to magnesium in hippocampal slices from immature rats. Devel. Brain Res. 56:257-262, 1990. 46) Xie, CW and Lewis, DV. Opioid mediated facilitation of long term potentiation in the lateral perforant path of the dentate gyrus. J. Pharmacol. Exp. Ther., 256:289-296, 1991. 47) Vedanarayanan, V. , Kandt, R.S., Lewis, D.V., and DeLong, G.R. Chronic inflammatory demyelinating polyradiculopathy of childhood: Treatment Neurology,41:828-830, 1991. 48) Morrisett, RA, Mott, DD, Lewis, DV, Swartzwelder, HS and Wilson, WA. GABAB receptor mediated inhibition in the N-methyl-D- aspartate component of synaptic transmission in rat hippocampus. J. Neurosci., 11:203-209, 1991. 49) Mott, DD and Lewis, DV. Facilitation of the Induction of Long- Term Potentiation by GABAB Receptors. Science, 252:1718-1720, 1991. 50) Walczak, TS, Lewis, DV and Radtke, R. Scalp EEG differs in temporal and extratemporal complex partial seizures. J. Epilepsy, 4:25-28, 1991. 51) Morrisett, R.A., Martin, D., Oetting, T.A., Lewis, D.V., Wilson, W.A. and Swartzwelder, H.S., Ethanol and Mg ions inhibit N-Methyl-D-Aspartate
interactive manner. Neuropharmacology. 20:1173-1178, 1991 52) Mott, D.D., Xie, C.W., Wilson, W.A., Swartzwelder, H.S. and Lewis, D.V. The physiological significance of GABAB receptor mediated disinhibition in the dentate gyrus. Pharmacol. Comm. 2:104-108, 1992. 53) Xie, C.W., Morrisett, R.A. and Lewis, D.V. Effects of activation of mu opioid receptors on synaptic currents of dentate granule cells. J. Neurophysiol. 68:1113-1120, 1992. 54) Walczak, T.S., Radtke, R. and Lewis, D.V., Accuracy and interobserver reliability of scalp ictal EEG. Neurology 42:2279- 2285, 1992. 55) Morrisett, R.A., Lewis, D.V., Swartzelder, H.S., and Wilson, W.A. Antiepileptic effects of GABAB receptor activation in area
CA3 of rat hippocampus. Brain Res. 600: 235-242, 1993. 56) Jones, L.S., Grooms, S.Y., Lapadula, D.M. and Lewis, D.V., Protein synthesis inhibition blocks maintenance but not induction of epileptogenesis in hippocampal slice. Brain Res. 599: 338-344, 1992. 57) Lee, E.K., Armon, C., Duginski, T.M., Lewis, D.V. and Radtke, R.A. False lateralization of scalp EEG seizure onset. J. Epilepsy 6:220-223, 1993. 58) Mott, D.D., Xie, C.W., Wilson, W.A., Swartzwelder, H.S. and Lewis, D.V. GABAB autoreceptors mediate activity dependent disinhibition and enhance signal transmission in the dentate gyrus. J. Neurophysiol. 69:674-691, 1993. 59) Radtke, R.A., Hanson, M.W., Hoffman, J.M., Crain, B.J. Walczak, T.S., Lewis, D.V., Beam, C., Coleman, R.E. and Friedman, A.F., Temporal lobe hypometabolism on positron emission tomography: Predictor of seizure control after temporal lobectomy, Neurology 43:1088-1092, 1993. 60) Radtke, R.A., Hanson, M.W., Hoffman, J.M., Heinz, ER, Walczak, T.S., Lewis, D.V., Coleman, R.E. and Friedman, A.F. Positron emission tomography: Comparison of clinical utility in temporal lobe and extra-temporal lobe epilepsy. J. Epilepsy, 7:27-33, 1994. 61) Lee, N, Radtke, RA, Hoffman, JM, Gray, L, Burger, PC, Montine, TJ, DeLong, RG, Lewis, DV, Oakes, WJ, and Friedman, AH. Neuronal migration disorders: Positron emission tomography correlations. Neurology, 35:290-297, 1994. 62) Tein, R.D., Felsberg, G.J., Campi de Castro, C., Osumi, A.K., Lewis, D.V., Friedman, A.H., Crain, B. and Radtke, R.A. Complex partial seizures and mesial temporal sclerosis: Evaluation with fast spin echo MR imaging. Radiology 189:835-842, 1993. 63) Tien,R.D., Ashdown,B.C., Lewis, D.V., Atkins,M.R. and Burger, P.C. Rasmussen's encephalitis: Neuroimaging findings in four patients. Amer. J. Radiol. 158:1329-1332, 1992. 64) Nohria, V, Tien, RD, Lee, N, Heinz, ER, Smith, JS, DeLong, GR, Skeen, MB, and Lewis, DV. MRI evidence of hippocampal sclerosis in progression: A case report. Epilepsia, 35:1332-1336, 1994.
65) Tennison, M.B., Greenwood, R.S., Lewis, D.V. and Thorn, M. Discontinuing antiepileptic drugs in children with epilepsy: A comparison of a six week and nine month taper period. New England Journal of Medicine, 330:1407-1410, 1994. 66) Tsujino, S., Tonin, P., Shanske, S., Nohria, V., Boustany, R.M., Lewis, D., Chen, Y.T. and DiMauro, S. A splice junction mutation in a new myopathic variant of phosphoglycerate kinase deficiency (PGK North Carolina). Ann. Neurol. 35: 349-353, 1994. 67) Xie, CW and Lewis, DV. Blocking δ opioid receptors unmasks LTP of synaptic inhibition in the dentate gyrus. Regulatory Peptides 54: 73-74, 1994. 68) Brucato, FH, Mott, DD, Lewis, DV. Wilson, WA, and Swartzwelder, HS. GABAB receptors modulate synaptically evoked responses in the rat dentate gyrus in vivo. Brain Res. 677:326- 332, 1995. 69) Xie, CW and Lewis, DV. Endogenous opioids regulate LTP of synaptic inhibition in the dentate gyrus of the rat. J. Neurosci. 15:3788-3795, 1995. 70) Lee, N., Tien, R.D., Lewis, D.V., Friedman, A.H., Felsberg, G.J., Crain, B., Hulette, C., Smith, J.S., Kim, J.H., Osumi, A.K., VanLandingham, K.E. and Radtke, R.A., Fast spin echo magnetic resonance
Correlation with neuronal density in temporal lobectomy patients. Epilepsia, 36:899-904, 1995. 71) Xie, CW and Lewis, DV. Depression of LTP by Naloxone in Rat Dentate Gyrus Is Reversed By GABAA Blockade. Brain. Res. 688:56- 60, 1995. 72) Xie, CW and Lewis, DV. Mu opioids inhibit NMDA currents in dentate granule cells through a G protein mediated mechanism. Analgesia 1: 870-873, 1995. 73) Lewis, DV, Thompson, RJ, Santos, CC, Radtke, RA, Oakes, WJ, Radtke, RA, Freidman, AH, Lee, N and Swartzwelder, HS. Outcome of Temporal Lobectomy in Adolescents, J. Epil. 9:198-205, 1996. 74) Brucato, FH, Levin, ED, Mott, DD, Lewis, DV. Wilson, WA, and
Swartzwelder, HS. Hippocampal LTP and Spontaneous Learning in Rat: Effects of GABAB Receptor Blockade. Neurosci. 74:331-339, 1996. 75) Andrews, PI, McNamara, JO, and Lewis, DV. Clinical and Electroencephalographic Correlates in Rasmussen's Encephalitis. Epilepsia. 38:189-194, 1997. 76) Mott, DD, Turner, DA, Okazaki, MM and Lewis, DV. Interneurons of the dentate hilus border of the rat dentate gyrus: Anatomical and Electrophysiological Heterogeneity. J. Neurosci. 17:3990- 4005, 1997. 77) Xie, CW and Lewis, DV. Involvement of cAMP dependent protien kinase in mu opioid modulation of NMDA receptor dependent synaptic currents. J. Neurophysiol. 78:759-766, 1997. 78) Vanlandingham, KE, Heinz, JE, Cavazos, JE, and Lewis, DV. MRI evidence of hippocampal injury following prolonged, focal febrile convulsions. Ann Neurol,43:413-426, 1998. 79) Tennison M Kankirawatana, P, Bowman, MR, Greenwood, R Lewis, D, and Burchinal, M. Effect of antiepileptic drug therapy on California achievement test scores. J. Epilepsy,11:208-214,1998. 80) Mott, DD, Li, Q, Okazaki, MM, Turner, DA, Li, Q, and Lewis, DV. GABAB receptor mediated currents in interneurons of the dentate hilus border. J. Neurophysiol, 82:1438-1450, 1999. 81) Kassem-Moussa, H, Provenzale, JM, Petrella, JR, and Lewis, DV. Early diffusion weighted MR abnormalities in status epilepticus. Amer. J. Roent. 174: 1304-1306, 2000. 82) Foldvary, N, Nashold, B, Mascha, E, Thompson, EA, Lee, N, McNamara, JO, Lewis, DV, Luther, JS, Friedman, AH, and Radtke, RA. Seizure outcome after temporal lobectomy for temporal lobe epilepsy: A Kaplan-Meier survival analysis. Neurology 54:630-634, 2000. 83) Jobe A, Lewis DV, Wainwright M, DeLong GR. Three children with a syndrome of obesity and overgrowth, atypical psychosis, and seizures: A problem in neuro-psychopharmacology Journal of Child Neurology 15:518-528, 2000. 84) Wainwright, MS, Martin, PL, Morse, RP, Lacaze, M, Provenzale,
JM, Coleman, RE, Morgan, MA, Hulette, C, Kurtzberg, J, Bushnell, C, Epstein, L, and Lewis, DV. Human herpesvirus 6 limbic encephalitis after stem cell transplant. Annals of Neurology, 50:612-619, 2001. 85) Verma, A, Lewis, D, Vanlandingham, KE, Husain, AM, Friedman, AH, Thompson, E, and Radtke, RA. Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy. Epil Res 47:9-15, 2001. 86) Lewis, DV, Barboriak D,MacFall, JR, Provenzale, JM, Mitchell, TV,and VanLandingham, KD Do Prolonged Febrile Seizures Produce Medial Temporal Sclerosis? Hypotheses, MRI Evidence and Unanswered Questions. Prog in Brain Res, 135:263-278, 2002. 87) Li, Q, Clark, S, Lewis, DV, and Wilson, WA. NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: A potential mechanism of neurotoxicity. J Neurosci, 22:3070-3080, 2002. 88) Gorospe, JR, Naidu, S, Johnson, A, Ayuste, O, Puri, V, Raymond, G, Jenkins, S, Pedersen,R, Lewis, D, Knowles, P, Fernandez, R, and Hoffman, E. Clinical and molecular characterization of Alexander disease patients. Neurology. 58(10):1494-500, 2002 89) Li, Q, Guo-Ross, S, Lewis, DV, Turner, D, White, AM, Wilson, WA,
supplementation enhances excitatory function and morphology of hippocampal CA1 pyramidal cells. Journal of Neurophysiology. 91(4):1545-55, 2004 Apr. 90) Sathornsumette, S, Schanberg, L, Rabinovich, E, Lewis, D, and Weisleder, P. Parry-Romberg syndrome with fatal brain stem involvement. J. Pediatr. 146:429-431, 2005. 91) Li, Q, Kuhn, CM, Wilson, WA and Lewis, DV. Effects of Gamma Hydroxybutyric Acid on Inhibition and Excitation in Rat Neocortex. Neuroscience 150:82-92, 2007. 92)Provenzale, JM, Barboriak,DP, Vanlandingham, K, MacFall J, Delong D and Lewis DV. Hippocampal MR Imaging Signal Hyperintensity
Predictive of Subsequent Mesial Temporal Sclerosis American Journal of Roentgenology, 190:976-983, 2008. 93) Shinnar S, Hesdorffer DC, Nordli DR Jr, Pellock, JM, O’Dell C, Lewis, DV, Frank LM, Moshé SL, Epstein, LG, Marmarou A, Bagiella E and the FEBSTAT study team. Phenomenology of Prolonged Febrile Seizures: Results of the FEBSTAT study. Neurology 71: 170-176, 2008. 94) Epstein LG, Shinnar S, Hesdorffer DC, Nordli DR Jr, Pellock, JM, O’Dell C, Frank LM, Lewis, DV, Moshé SL, Epstein, LG, Marmarou A, Bagiella E and the FEBSTAT study team. The Role of Human Herpesvirus 6 and 7 Primary Infection in Febrile Status Epilepticus Submitted NEJM, 2007. 95)Provenzale, Vanlandingham, Lewis, White et al. Extra hippocampal involvement in human Herpesvirus 6 encephalitis depicted at MR imaging. Radiology 249:955-963, 2008. 96) Puranam et al. Chromosomal translocation disrupts FGF13 gene in family with febrile seizures and mesial temporal lobe epilepsy. Submitted, Neuron, 2007. 97) Morey RA, Petty CM, Xu Y, Hayes JP, Wagner HR, Lewis DV, Labar KS, Styner M, and McCarthy G. A Comparison of Automated Segmentation and Manual Tracing for Quantification of Hippocampal and Amygdala Volumes In Press Neuroimage, 2008. CHAPTERS and REVIEWS: 1) Wilson WA, Zbicz KL, Lewis DV: Enhancement of spike frequency adaptation by anticonvulsants. In, "Physiology and Pharmacology of Epileptogenic Phenomena". pp 259-267 (Eds: Klee MR, Lux HD, Speckman EJ) Raven Press NY 1982. 2) Lewis DV, Huguenard JP, Anderson WN, Wilson WA: Membrane currents underlying bursting pacemaker activity and spike
frequency adaptation in invertebrates. In, "Basic Mechanisms of the Epilepsies Molecular and Cellular Approaches". Adv. Neurol. Vol. 83 44 (Eds: Delgato-Esqueta, AV, Ward AA, Woodbury DM) Raven Press NY Chapter 11, 1986. 3) Lewis DV and Wilson WA: Spontaneous electrographic seizures in the hippocampal slice: An in vitro model for the study of the transition from interictal to ictal activity. In, "Kindling 4". (Ed. J. Wada) Plenum Press, NY, 11-19, 1990. 4) Wilson, WA, Stasheff, S, Swartzwelder, S, Clark, S, Anderson, AA, and Lewis, DV. The NMDA receptor in epilepsy. In, "The NMDA Receptor" pp 166-176. (Eds. JC Watkins and GL Collingridge). Oxford University Press, Oxford, 1989. 5) Mott, DD and Lewis, DV. GABAB Receptors Mediate Disinhibition and Facilitate Long Term Potentiation in the Dentate Gyrus. In, "The Dentate Gyrus and Its Role in Seizures" (Eds. C. Ribak, C. M. Gall and I. Mody). Epilepsy Research Supplement 7. Chapter 8; pp 119-134, 1992. 6) Lewis, DV, Mott, DD, Swartzwelder, HS and Xie, CW. The role of GABAB receptors in stimulus dependent disinhibition and the induction of long term potentiation. In, "Presynaptic Receptors in the CNS: Physiology and Pharmacology" (Eds. T.V. Dunwiddie and D.M. Lovinger). Springer-Verlag, pp 160-179, 1993. 7) Mott, DD and Lewis, DV. Pharmacology and Function of Central GABAB Receptors. In, "International Review of Neurobiology", (Eds. R.J. Bradley and R.A. Harris). Academic Press, Vol 36:97- 210, 1994. 8) Clark, S, Stasheff, S, Lewis, DV, Martin, D, and Wilson, WA. The NMDA Receptor in Epilepsy. In, "The NMDA Receptor", (Eds. JC Watkins and GL Collingridge). Oxford University Press, Oxford, pp 313-339, 1994. 9) Lewis, DV. Febrile convulsions and mesial temporal sclerosis. Current Opinion in Neurology. 12:197-201,1999 10) Mitchell, TV and Lewis, DV. Do prolonged febrile seizures injure the hippocampus: Human MRI studies. In, Febrile Seizures, Eds. TZ Baram and S Shinnar, 103-121, 2002.
11) Lewis, DV and Shinnar, S. Febrile Status Epilepticus. In, Epilepsy, A Comprehensive Textbook, Eds. Engel and Pedley, 731 - 736, 2008. CONSULTANT APPOINTMENTS AND COMMITTEES: Member, Committee of Neurology Clinic Standards, North Carolina Crippled Children's Program Ad Hoc Member (1982,1992) Project Review B Committee, Neurological Disorders Program, N.I.N.C.D.S. Ad Hoc Member, Neurology Study Section A, National Institutes of Health, February 1986 and 1988. Member Neurobiology Steering Committee, Duke University Medical Center, December 1985 - January 1986. Member Neurobiology Search Committee, Duke University Medical Center, May 1988 - March 1989. Editorial Advisory Board, Jasper's Basic Mechanisms of the Epilepsies, 1992 - 1997. Member Neonatology Search Committee, Duke University Medical Center, May 1992 - August 1992. Member American Epilepsy Society Awards Committee, 1993 - 1995. Member Hematology Oncology Search Committee, Duke University Medical Center, August 1993 - January 1995. Ad Hoc Member, Neurobiology 2 Study Section, National Institutes of Health, 1993 - 1998. Member, Neurological Sciences 2 Study Section, National Institutes of Health, June 1994 - February 1998. Special Services Advisory Committee, Duke University Medical Center, December 1994 - December 1996. SOCIETIES: American Epilepsy Society
DISCURSO PARA O ENCONTRO NA UNIVERSIDADE DE ROMA "LA SAPIENZA" Magnífico ReitorExcelentíssimas Autoridades políticas e civisIlustres professores e pessoal técnico-administrativo,Queridos jovens estudantes!É para mim motivo de profunda alegria encontrar-me com a comunidade da"Sapienza Universidade de Roma", por ocasião da inauguração do ano académico. Háséculos q