Microsoft word - 10971-polycystic_ovary_syndrome.docx
Polycystic ovary syndrome (PCOS) is a disorder that affects as many as 5–10% of
women. PCOS has three key features: 1) high levels of hormones called an
periods or lack of periods; and (3) the presence of growths called cy
PCOS have other signs and symptoms as well.
The cause of PCOS is not known, but it may be at least partly genetic (passed down through a person's
genes). With proper diagnosis, the symptoms of PCOS can be treated successfully. Long-term treatment
may be needed to prevent the health risks associated with the disease.
health risks associated with PCOS
PCOS has many different signs and symptoms. Some women may not be aware that seemingly unrelated
symptoms are actually those of PCOS. Common PCOS signs and symptoms include the following:
Irregular menstrual periods—Menstrual bleeding may be absent, heavy, or unpredictable.
e tility—PCOS is one of the most common causes of female infertility.
Obesity—Up to 80% of women with PCOS are obese.
Excess hair growth on the face, chest, abdomen, or upper thighs—This condition, called
s , affects more than 70% of women with PCOS.
Severe acne or acne that occurs after adolescence and does not respond to usual treatment
Patches of thickened, velvety, darkened skin called aca
Multiple small cysts on the ovaries
Not all women with PCOS have all of these symptoms. Often women find out they have PCOS when they
see a health care provider because of irregular menstrual periods or difficulty becoming pregnant.
How PCOS Affects the Female Reproductive
Although the cause of PCOS is not known, it appears that PCOS may be related to many different factors
working together. These factors include insu
s lin resistance, increased androgen levels, and an irregular
Insulin resistance plays a key role in PCOS. Insulin is a hormone that helps move gluco
c lls for the energy the body needs. If the body's cells do not respond to the
effects of insulin, the level of glucose in the blood increases. Higher than normal blood glucose levels may
ellitus, a health condition that can cause serious complications if it is not
managed. Insulin resistance also may cause more insulin to be produced as the body tries to move
glucose into cells. High insulin levels may cause the appetite to increase and lead to imbalances in other
hormones. Insulin resistance also is associated with acanthosis nigricans.
High levels of androgens are a hallmark of PCOS. Androgens are hormones made by the ovaries and
adrenal glands (small glands that rest on top of the kidn
y ). All women produce a certain amount of
these hormones. When higher than normal levels of androgens are produced, it can prevent the ovaries
from releasing an egg each month (a process called ovul
a ion). High androgen levels also cause the
unwanted hair growth and acne seen in many women with PCOS.
Women with PCOS often have irregular menstrual periods. Some have infertility. These problems are
caused by lack of regular ovulation. Women who do not ovulate regularly may form multiple ovarian cysts.
Despite the name of the disorder, the presence of cysts on the ovaries does not mean that a woman has
PCOS. Cysts on the ovaries are common in women and may not be related to PCOS. However, women with
PCOS may have more follicles in their ovaries than women without PCOS. Follicles are the fluid-filled sacs
Metabolic syndrome is a combination of factors that increases a
person's risk of diabetes and cardiovascular disease. About 30%
of women with PCOS also have metabolic syndrome. Metabolic
syndrome is diagnosed when a person has at least three of the
Waist measurement of 35 inches or more
Higher than normal blood glucose level
Lower than normal levels of “good” ch
High levels of fats in the blood (triglycerides)
PCOS affects all areas of the body, not just the reproductive system. It increases a woman's risk of serious
conditions that may have lifelong consequences.
Insulin resistance increases the risk of type 2 diabetes mellitus and ca
often occurs with insulin resistance, also is associated with type 2 diabetes and heart disease. Another
condition that is associated with PCOS is metabo
d ome (see box). This syndrome contributes to
Women with PCOS tend to have a condition called endo
d metrium) becomes too thick. This condition increases the risk of endometrial cancer.
There is no one accepted definition of PCOS. PCOS is diagnosed when a woman has two of the three key
Increased levels of androgens, either by measuring the levels of androgens in the blood or by
noting the presence of unwanted hair growth
Lack of menstrual periods or irregular menstruation
If your health care provider thinks that you have PCOS, other conditions that might cause any of the three
features first must be ruled out. The diagnosis is based on your medical history, a physical exam, and
results of lab tests. The medical history will include information about your menstrual cycle and history of
infertility. During the physical exam, your health care provider will look for patterns of excess hair growth,
acne, or other signs of high androgen levels. A test may be done to check the level of androgens in your
a may be done to look for cysts on your ovaries.
Because of the possibility of insulin resistance, the level of glucose in your blood may be measured to
screen for diabetes. Your risk of cardiovascular disease may be assessed with a blood test to check
cholesterol levels and measurements of your blood pressure, weight, waist, and hips.
A variety of treatments are available to address the problems of PCOS. Treatment is tailored to each
woman according to symptoms, other health problems, and whether she wants to become pregnant.
Combination birth control pills can be used for long-term treatment in women with PCOS who do not wish
to become pregnant. Combination pills contain both estrogen and pr
s in. Birth control pills may help
relieve several PCOS symptoms. They regulate the menstrual cycle and reduce hirsutism and acne by
decreasing androgen levels. They also cause the lining of the uterus to be shed on a regular basis, which
decreases the risk of endometrial cancer. No specific type of combination birth control pill has been
shown to be more effective than others in treating PCOS symptoms.
For overweight women, weight loss alone often regulates the menstrual cycle. Even a small weight loss of
10 to 15 pounds can be helpful in making menstrual periods more regular. Weight loss also has been
found to improve cholesterol and insulin levels and relieve symptoms such as excess hair growth and
Insulin-sensitizing drugs used to treat diabetes frequently are used in the treatment of PCOS. These drugs
help the body respond to insulin. In women with PCOS, they are associated with a decrease in androgen
levels and improved ovulation. Restoring ovulation helps make menstrual periods regular and more
Successful ovulation is the first step toward pregnancy. For overweight women, weight loss often
accomplishes this goal. Medications also may be used to cause ovulation. Clomiphene citrate is the most
common drug used for this purpose. Adding a drug called metformin, an insulin-sensitizing drug, to
clomiphene citrate may increase the likelihood of pregnancy, especially in women who are obese. When
treatment with clomiphene does not work, drugs called gonadotropins may be tried. Both gonadotropins
and clomiphene increase the chance of multipl
c . Multiple pregnancy can lead to pregnancy
problems, including an increased risk of preterm birth and high blood pressure during pregnancy.
Surgery on the ovaries has been used when other treatments do not work. However, the long-term effects
of these procedures are not clear.
Prevention of Diabetes and Cardiovascular Disease
Losing weight through a reduced-calorie diet combined with regular exercise is the best way to reduce the
risk of diabetes in women with PCOS. Regular exercise and maintaining a healthy weight can help prevent
a ins are drugs that lower cholesterol. An increasing amount of research shows that statins have good
effects on cardiovascular health in women with PCOS.
Metformin has been used in the treatment of women with PCOS, often in addition to lifestyle changes such
as weight loss. In women with PCOS, metformin improves the way the body responds to insulin and helps
Treating Hirsutism and Skin Problems
For many women, hirsutism is one of the most disturbing symptoms of PCOS. There are many ways to
manage this condition. A combination of treatments often works best.
Birth control pills may prevent growth of excess hair. If they do not, antiandrogen drugs may be added.
These drugs prevent the body from making androgens or limit the effects of androgens. Women who may
become pregnant should not take antiandrogens because they can cause birth defects.
A drawback of these medications is that they may take several months to work. While waiting for these
drugs to take effect, many women with PCOS use shaving, plucking, waxing, and depilatory creams for
hair removal. Laser treatment and electrolysis are noninvasive surgical methods for removing hair that can
be effective. Repeat treatment might be necessary.
Retinoids (drugs that are related to vitamin A), antibacterial medications, and antibiotics are used to treat
acne. Women who may become pregnant should not use retinoids because they can cause birth defects.
With proper treatment, PCOS can be managed, and you can expect relief from symptoms. Long-term
preventive health care is important for a healthy future. Your health care provider can offer you many
options, but a healthy diet and regular physical activity are lifestyle choices you can make for yourself that
can play a large role in reducing the symptoms of PCOS.
s Patches of thickened, velvety, darkened skin that is sometimes associated with
s Steroid hormones produced by the adrenal glands or by the ovaries that promote male
characteristics, such as a beard and deepening voice.
s : Disease of the heart and blood vessels.
s The smallest units of a structure in the body; the building blocks for all parts of the body.
s erol: A natural substance that serves as a building block for cells and hormones and helps to carry
fat through the blood vessels for use or storage in other parts of the body.
s Sacs or pouches filled with fluid or other material.
s A condition in which the levels of sugar in the blood are too high.
a A condition in which the lining of the uterus grows too thick; if left untreated for
a long time, it may lead to cancer.
s rogen: A female hormone produced in the ovaries.
s The saclike structures that form inside an ovary when an egg is produced.
s DNA “blueprints” that code for specific traits, such as hair and eye color.
s : A sugar that is present in the blood and is the body's main source of fuel.
s : Excessive hair on the face, abdomen, and chest.
s Substances produced by the body to control the functions of various organs.
y A condition in which a couple has been unable to get pregnant after 12 months without the use
i : A hormone that lowers the levels of glucose (sugar) in the blood.
s Two organs that cleanse the blood, removing liquid wastes.
d ome: Combination of factors that contribute to both diabetes and heart disease.
y A pregnancy in which there are two or more fetuses.
s Two glands, located on either side of the uterus, that contain the eggs released at ovulation and
a ion: The release of an egg from one of the ovaries.
s in: A synthetic form of progesterone that is similar to the hormone produced naturally by the body.
s Drugs used to treat cholesterol abnormalities.
a : A test in which sound waves are used to examine internal structures.
This Patient Education Pamphlet was developed by the American College of Obstetricians and
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J. Phys. D: Appl. Phys. 34 (2001) R125–R149 TOPICAL REVIEW Function and applications of gas sensors Dieter Kohl Institute of Applied Physics, University of Giessen, Holbeinring 16, D-35390 Giessen,GermanyReceived 3 April 2001Published 18 September 2001Online at stacks.iop.org/JPhysD/34/R125 Abstract Gas sensors directed to high-volume applications are discussed. Mainly semiconduct
BIOÉTICA E CUIDADO DO BEM-ESTAR HUMANO: ÉTICA, HUMANIZACAO E VOCACAO COMO DESAFIO PARA OS PROFISSIONAIS DA SAÚDE Resumo: a bioética vem se tomando um grande lance de eperanca na contemporaneidade em relacao ao resgate da dignidade do ser humano e ao impulsionar acoes de cuidado deste ser fragilizado pela doenca e pelo sofrimento no ámbito da saude. Fala-se muito hoje da desum