NSAIDS/Sulfa Drugs/Deramaxx and Dobermans Some Doberman Pinschers apparently are very sensitive to Sulfa (not Sulfur) drugs. Many have had horrible reactions to Duramaxx in particular. One was a female named Silk who had such a reaction to the drug that she sloughed off her entire stomach lining. Fortunately for Silk, after many weeks of treatment, she recovered. Her story is as follows: Cheryl Hartman first reported: “Silk, my 9 year old Dobie, injured her left rear leg and was prescribed Deramaxx® which she took for just two days. Needless to say, three days and $1,500.00 dollars later, the specialists are still giving her IV fluids. A scope was performed today by an internal medicine specialist who found that the entire stomach lining had been sloughed off. Her symptoms were violent vomiting which included blood, bloody stool and bleeding from the rectum. IV fluids will be maintained for at least two more days, which will make that a total of 5 days on IV fluids.” Date: Fri, 28 Feb 2003 15:09:43 -0600 From: Cheryl Hartman <jvcdobe@SWBELL.NET> Subject: Medical: Deramaxx ---- CAUTION I am sending this post in hopes of saving someone else, and their beloved pet the agony in which Silk & I have recently gone through with Deramaxx. After only two doses of Deramxx (chewable pills), Silk became violently ill, vomiting constantly. On two occasions, she vomited blood.lots of blood. I brought her home yesterday, after being on IV fluids for 10 hours. She had two BM's yesterday and both contained a good portion of blood as well. This morning, I made the decision to transfer her to another vet specialist to have her scoped. The Internal medicine specialist called me at 2:00 pm today, to inform me that Silk's entire stomach lining had been sloughed off due to the Deramaxx. Silk will be on IV fluids for at least three more days, and then soft food for weeks. Luckily, Merrimac's Sweet Inspiration, CD is vWD Clear. If she had been a bleeder, I probably would have lost her for sure. According to the Internal medicine Vet.ONE more dose of this medication would have killed her as well. It heart breaking to see the animal you love so dearly, suffer so much. I laid on the bed with her last night and watched blood drain from her rectum. Silk is 9 1/2 years old, and did not deserve this. I have learned another very valuable lesson at the expense of my beloved baby girl. So please, spare your animals the agony and pain that Silk & I have had to endure the last few days. Don't give DERAMAXX to your Dobers.PLEASE! See the FDA website on Deramaxx. http://www.fda.gov/cvm/index/ade/adetoc.htm DERAMAXX = deracoxib BTW, I will be reporting this drug reactions to not only the manufacturer, but the FDA as well. Thanks for your time, and if this post saves one Dobes life.it's worth it Cheryl, Silk & Reina~. As of March 14th 2003, Cheryl's bill for treating Silk is now $3,470.53. Another report regarding Deramaxx is as follows: Date: Sat, 25 Dec 2004 14:49:47 -0500 From: Kathy Davieds <momdog@swva.net> Subject: Doberman and NSAIDS/Deramaxx: report NSAIDS, or non-steroidal anti-inflammatory drugs, are useful medications for numerous anti-inflammatory and pain relief purposes. They are also a category of drugs that have the potential for serious to sometimes fatal side effects. In human medicine, some of the most commonly recognized NSAIDS include Vioxx and Celebrex. In veterinary medicine, three commonly used NSAIDS are Rimadyl (carprofen), Etogesic (etodolac) and more recently, Deramaxx (deracoxib). Canyon was a strong, vigorous, 8 and a quarter year old black male Doberman that I nurtured from birth until his placement with a wonderful family at the age of 8 weeks. His sire lived several thousand miles away, so his mom and I travelled at length to get his litter safely inside her. His carefully screened new home was half that distance away, so his new people and I travelled one day each to meet in the middle, then spent hours on introductions and review of a thousand specifics. I cherished the updates Canyon's mom and dad sent regularly since 1996. He was still swimming in the bay and taking daily walks with them two weeks ago. He was full of life. They were about to send me a major updated photo album. They reported again how *our days revolve around Canyon*, what a wonderful, happy, active boy he was and how gentle he was with their two year old grandchild. The next email subject was entitled *tragic news about Canyon*. Ever the devoted owners, they'd noticed last month the very occasional, ever so slightly slower to rise in the morning stiffness. Not wanting him to suffer the slightest discomfort from arthritis, they took him to their regular veterinarian. Perhaps he would do some Xrays, bloodwork or other diagnostics.No diagnostics were performed; instead, he was given 2 weeks worth of Deramaxx, 100 mg daily. Canyon had been going to this veterinarian for years and the owners had no reason to question anything. When Canyon lost his appetite and began vomiting, they called the vet to report these symptoms. The same for the diarrhea, and the dry heaves. And the lethargy and the weakness. Then the drastically increased water consumption. And then the collapse and seizures. They had no idea there was any relationship to the medication. Because their trusted vet had given no indication there might be side effects, they thought something else was wrong with their beloved boy. Each time they called, about al of the above symptoms, they were told not to worry, and to keep giving him his Deramaxx. By the time their *son* died in their arms on the 11th day, he had exhibited nearly every one of the well documented side effects of Deramaxx.Can anyone reading this even conceive of the horror these people are living at this time, having discovered the list of side effects of Deramaxx on their own, because I hadn't the heart to tel them? They see themselves putting the pills down his throat, the vet's office telling them everything was ok, keep giving the medicine, and see their boy dying in their arms in a manner I don't even wish to repeat here. What I will repeat is this: anti-inflammatory drugs are useful. They definitely have their place. However, there is NO EXCUSE WHATSOEVER for dispensing them without 1) bloodwork first- at least in middle aged to older dogs- to insure normal kidney and liver function, as product literature clearly indicates, and 2) 30 to 60 seconds worth of *client education* informing of potential side effects to watch for and that the drug should be stopped if any of the side effects occur. That's all it takes to save lives: 30 to 60 seconds. Canyon did not have to die this way. He was happy and healthy: his cardiac evaluations every 6 to 12 months showed excellent cardiac health, his 10 littermates minus one tragic escape/hit-by-car are alive and doing well as are his mother and her 5 littermates at nearly 11 years of age. His owners say, if only we'd known. We didn't know we had to check up on our own about the safety of a drug dispensed by our vet. We would have done ANYTHING for our boy. Please, forward this report to everyone you know who loves dogs. And please, please: speak with your veterinarian- not in an accusatory manner, but respectfully requesting their assistance. Do they advise every client to whom they dispense Rimadyl, Etogesic, Deramaxx, of potential side effects? And to stop giving the drug and call the hospital immediately if any of the side effects occur? If yes, indicate your deepest appreciation for their caring attention to these details. If not, ask *Will you please institute this as a hospital policy immediately? Will you please make it a rule that NSAIDS will only be dispensed with client education regarding potential side effects?* Hug your babies today on Christmas, as Canyon's owners cannot, and please vow to do this to make a difference for al Dobermans and dogs in the future. Let's keep them comfortable, but let's keep them alive. Thank you, Kathy Davieds, DVM You can read more about on the web at: Deramaxx information http://www.cyberdobes.com/PDF/Deramaxx.pdf Edward Murray's website http://home.insightbb.com/~e.murray/index.html More tales of Deramaxx and side effects. http://www.cafepharma.com/ubbthreads/showflat.php?Cat=0&Number=549612&Main=547734 Sulfa Drugs: 1) Tribrissen (Trimethoprim/Sulfadiazine) 2) Ditrim (Trimethoprim/Sulfadiazine) 3) Bactrim (Trimethoprim/Sulfadiazine) 4) Septra (same as Bactrim) 5) Cotrim (same as Bactrim) 6) Comoxol (same as Bactrim) 7) Albon (Sulfadimethoxine/Ormetoprim) 8) Bactrovet (same as Albon) 9) Primor (Sulfadimethoxine/Ormetoprim) 10) Azulfidine (Sulfasalazine) 11) Apo-Sulfatrim 12) Novo-Trimel 13) Deramaxx
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