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FRIDAY, Feb. 8 (HealthDay News) -- Chronic pain
can disrupt brain function and cause problems such Related
SOURCE: Northwestern University, news release,
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as disturbed sleep, depression, anxiety and difficulty Encyclopedia Learn about an
making simple decisions, a U.S. study finds.
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Researchers at Northwestern University's Feinberg • Bell's Palsy
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School of Medicine in Chicago used functional MRI to
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scan brain activity in people with chronic low back
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pain while they tracked a moving bar on a computer
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screen. They did the same thing with a control
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In those with no pain, the brain regions displayed a
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state of equilibrium. When one region was active,
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the other regions calmed down. But in people with
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chronic pain, the front region of the cortex mostly
associated with emotion "never shuts up," study
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author Dante Chialvo, an associate research
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professor of physiology, said in a prepared
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This region remains highly active, which wears out • Depakote
neurons and alters their connections to each other.
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This constant firing of neurons could cause
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"We know when neurons fire too much they may
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change their connections with other neurons or even Deadly
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die, because they can't sustain high activity for so
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"If you are a chronic pain patient, you have pain 24
hours a day, seven days a week, every minute of
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your life. That permanent perception of pain in your For Males, Video
brain makes these areas in your brain continuously • Game Rewards Are
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active. This continuous dysfunction in the
equilibrium of the brain can change the wiring
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forever and could hurt the brain," Chialvo explained.
These changes "may make it harder for you to make a decision or be in a good mood to get up in the morning. It could be that pain
produces depression and the other reported abnormalities, because it
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disturbs the balance of the brain as a whole," he said.
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The study was published in the Feb. 6 issue of The Journal of
Chialvo said the findings show that, along with finding new ways to
treat pain, it's also important to develop methods to evaluate and
prevent disruption of brain function caused by chronic pain.
More information
The American Academy of Family Physicians has more about chronic pain.
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